A5074719512- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Dermatology and Skin Diseases
- RNA modifications and cancer
- Alcohol Consumption and Health Effects
- Cancer-related gene regulation
- RNA Research and Splicing
- Allergic Rhinitis and Sensitization
- Food Allergy and Anaphylaxis Research
- Immunotherapy and Immune Responses
- CRISPR and Genetic Engineering
- Psoriasis: Treatment and Pathogenesis
- Complementary and Alternative Medicine Studies
- Folate and B Vitamins Research
- BRCA gene mutations in cancer
- Pediatric health and respiratory diseases
- Liver Disease Diagnosis and Treatment
- Tumors and Oncological Cases
- Dental Radiography and Imaging
- Urticaria and Related Conditions
- Molecular Biology Techniques and Applications
- DNA Repair Mechanisms
- Temporomandibular Joint Disorders
- Orthodontics and Dentofacial Orthopedics
Kunming Children's Hospital
2019-2025
Kunming Medical University
2025
Nanjing Medical University
2014-2021
Purpose: To evaluate the long-term efficacy and safety of secukinumab in pediatric patients with generalized pustular psoriasis (GPP).
Objective To provide a precise quantification of the association between alcohol and tobacco consumption trends in head neck cancer patients over past 45 years. Methods We combined findings from all studies published until March 2014 evaluated different levels cancers through meta-analytic approach. Results included 28 involving 13830 with cancer. In consumption, pooled odds ratio (OR) 95% confidence interval (CI) were 1.29(1.06-1.57), 2.67(2.05-3.48) 6.63(5.02-8.74) for light drinkers,...
MicroRNA (miRNA) polymorphisms may alter miRNA-related processes, and they likely contribute to cancer susceptibility. Various studies have investigated the associations between genetic variants in several key miRNAs risk of human cancers; however, few focused on head neck squamous cell carcinoma (HNSCC) risk. This study aimed evaluate miRNA HNSCC a Chinese population. In this study, we genotyped five common single-nucleotide (SNPs) (miR-149 rs2292832, miR-146a rs2910164, miR-605 rs2043556,...
To evaluate whether the genetic variants in H19 influence risk of oral squamous cell carcinoma (OSCC) a Chinese population, case-control study was conducted to analyze four functional single nucleotide polymorphisms (SNPs) H19. The cohort comprised 444 OSCC cases and 984 healthy controls, further evaluated biological effect by bioinformatics prediction experiments. Two SNPs, rs217727 rs2839701, were found be associated with [rs217727: odds ratio (OR) = 1.32, 95% confidence interval (CI)...
Abstract Objective Long non‐coding RNA (lncRNA) MEG3 was associated with multiple types of cancers such as oral squamous cell carcinoma (OSCC). Single nucleotide polymorphisms (SNPs) might affect cancer risk by modifying the function lncRNAs. But fewer study researched relationship between SNPs and in cancers. Considering these reasons, we supposed may influence OSCC. Material Methods The selected were genotyped 1,428 subjects (444 patients OSCC 984 cancer‐free controls). calculated logistic...
Abstract Telomere dysfunction participates in malignant transformation and tumorigenesis. Previous studies have explored the associations between telomere length (TL) cancer susceptibility; however, findings are inconclusive. The genetic variants TL been verified by quite a few genome-wide association (GWAS). Yet, to date, there was no published study on relationship TL, related susceptibility squamous cell carcinoma of head neck (SCCHN) Chinese. Hence, we detected relative (RTL) using...
Let-7 and Lin28 establish a double-negative feedback loop to affect several biological processes, such as differentiation of stem cell, invasion metastasis tumorigenesis. In this study, we systematically investigated the associations between 6 potentially functional SNPs let7 genes risk oral cavity cancer with case-control study including 384 cases 731 controls. We found that variant allele (T) rs221636 Lin28B was significantly associated reduced [odds ratio (OR) = 0.73, 95% confidence...
MicroRNAs (miRNAs) play important roles in regulation of gene expressions and likely have involvement cancer susceptibility disease progression. MicroRNA-101 (miR-101) has been well established as a tumor suppressor, aberrant expression miR-101 levels previously reported different malignancies including head neck squamous cell carcinoma (HNSCC). However, the role single nucleotide polymorphisms (SNPs) to HNSCC remains unclear. In this study, we genotyped 11 selected SNPs genes (including...
In order to investigate the effect of daily emollient treatment on infantile atopic dermatitis (AD) during maintenance period, a total 309 children younger than 2 years with moderate AD (155 and 154 in control groups, respectively) were enrolled this multicenter, randomized, parallel controlled clinical trial. Subjects topically treated desonide cream emollients Prinsepia utilis Royle for 2-4 weeks before entering period then differentially either or none control. The cumulative rate, time...
A recent study synthesized several published genome-wide association studies (GWAS) on three types of cancers and identified variants at 6p21.1 7p15.3 as candidate susceptibility loci for multiple human cancers. However, the role these in development head neck cancer (HNC) is still unclear.To evaluate relationships between genetic regions HNC risk, we genotyped two common SNPs rs2494938 rs2285947 a case-control with total 503 cases 900 controls Han Chinese.We found that was associated...
KITLG/KIT pathway plays a vital role in multiple types of human cancer including head and neck squamous cell carcinoma (HNSCC). Genetic variations KITLG KIT may affect the expression or function these genes, thereby modifying risk. In this study, we evaluated association polymorphisms with HNSCC risk among Chinese population. Twenty-two tagging SNPs genes were genotyped case-control study 576 patients 1552 healthy controls. Logistic regression analyses revealed that an upstream SNP rs6554198...
Abstract Background Atopic dermatitis (AD) is a chronic, recurrent pruritic, inflammatory skin disease associated with genetic allergies. Crisaborole phosphodiesterase 4 (PDE4) inhibitor approved by the US Food and Drug Administration for treatment of patients over 2 years age mild to moderate AD. Previous studies have focused on efficacy crisaborole in AD, its influence AD recurrence not clear. Objective To explore safety sequential topical 0.1% mometasone furoate cream (Elosone) children,...