A5033582283- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Immunotherapy and Biomarkers
- Cancer Mechanisms and Therapy
- Colorectal Cancer Treatments and Studies
- Lung Cancer Treatments and Mutations
- Pancreatic and Hepatic Oncology Research
- Cancer, Hypoxia, and Metabolism
- Liver physiology and pathology
- Liver Disease Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastric Cancer Management and Outcomes
- Hepatitis B Virus Studies
- Cancer Treatment and Pharmacology
- Hepatitis C virus research
- Microtubule and mitosis dynamics
- Ferroptosis and cancer prognosis
- Prostate Cancer Treatment and Research
- Immunotherapy and Immune Responses
- Metal complexes synthesis and properties
- Angiogenesis and VEGF in Cancer
- Cancer Genomics and Diagnostics
- Immune Cell Function and Interaction
- Renal cell carcinoma treatment
- Allergic Rhinitis and Sensitization
- Bladder and Urothelial Cancer Treatments
National Taiwan University
2012-2025
National Taiwan University Hospital
2012-2025
Stanford University
2025
University of Hawaiʻi at Mānoa
2024
Huzhou University
2024
Johns Hopkins Medicine
2021-2023
Johns Hopkins University
2015-2023
National Clinical Research
2009-2023
Northwest Women's and Children's Hospital
2021
Southwest University
2017-2018
Sorafenib is the only drug approved for treatment of hepatocellular carcinoma (HCC). The bioenergetic propensity cancer cells has been correlated to anticancer resistance, but such correlation unclear in sorafenib resistance HCC. Six sorafenib-naive HCC cell lines and one sorafenib-resistant line (Huh-7R; derived from sorafenib-sensitive Huh-7) were used. was calculated by measurement lactate presence or absence oligomycin. Dichloroacetate (DCA), a pyruvate dehydrogenase kinase (PDK)...
Abstract BACKGROUND: Antiangiogenic therapy has become the most important treatment modality for patients with advanced hepatocellular carcinoma (HCC). In this study, authors investigated levels of alpha‐fetoprotein (AFP) as a potential biomarker efficacy antiangiogenic therapy. METHODS: Patients HCC who had been enrolled in 3 prospective phase 2 clinical trials that evaluated either sorafenib, bevacizumab, or thalidomide combination potentially antiangiogenic, metronomic, oral...
632 Background: Nectin cell adhesion protein 4 (Nectin-4) is overexpressed in various malignancies, contributing to cancer progression and poor prognosis. We aimed assess Nectin-4 expression hepatocellular carcinoma (HCC). Methods: Patients who underwent primary liver tumor resection for HCC upon initial diagnosis at National Taiwan University Hospital 2019 were included. Exclusion criteria consisted of prior systemic or loco-regional therapy, death within three months post-surgery....
Abstract Female invasive breast cancer (FIBC) in Taiwan is characterized by a striking recent increase of incidence and relatively young median age (45-49 years) at diagnosis. The Westernization lifestyle that increasingly affecting younger generations Taiwanese may have an important impact on this change. We compared epidemiologic data FIBC obtained from the Cancer Registry with for Caucasian Americans database Surveillance, Epidemiology, End Results Program period 1980 to 1999....
Abstract Background: In the past two decades, incidence of breast cancer in young Taiwanese females has been rapidly increasing, approaching risk level western countries. As a first step to investigate possible etiology, we examined molecular subtypes female Taiwan. Methods: This study included 1,028 consecutive patients with diagnosed National Taiwan University Hospital between 2004 and 2006. Estrogen receptor (ER), progesterone (PR), human epidermal growth factor receptor-2, cytokeratin...
Immune checkpoint inhibitors (ICIs) exhibit significant clinical activity in patients with advanced hepatocellular carcinoma (HCC). This study explored whether tumor response to ICIs HCC varies among different organs.We reviewed the data of who had received ICIs. Patients measurable diseases were enrolled. Organ-specific criteria, adapted from RECIST 1.1 and immune-related RECIST, used evaluate objective tumors located liver, lung, lymph node, other intra-abdominal sites.Of 75 enrolled HCC,...
Background Preclinical data suggest that concurrent treatment of anti-CD38 and antiprogrammed death 1 (PD-1)/programmed ligand (PD-L1) antibodies substantially reduce primary tumor growth by reversing T-cell exhaustion thus enhancing anti-PD-1/PD-L1 efficacy. Methods This phase I/II study enrolled patients with metastatic castration-resistant prostate cancer (mCRPC) or advanced non-small cell lung (NSCLC). The objectives I were to investigate the safety tolerability isatuximab (anti-CD38...
Background Metal components of environmental PM2.5 are associated with the exacerbation allergic diseases like asthma. In our recent hospital-based population study, exposure to vanadium is shown pose a significant risk for current asthma, but causal relationship and its underlying molecular mechanisms remain unclear. Objective We sought determine whether co-exposure can aggravate house dust mite (HDM)-induced airway inflammation remodeling, as well investigate related mechanisms. Methods...
PURPOSE Durable partial response (PR) and durable stable disease (SD) are often seen in patients with hepatocellular carcinoma (HCC) receiving atezolizumab plus bevacizumab (atezo-bev). This study investigates the outcome of these histopathology residual tumors. PATIENTS AND METHODS The IMbrave150 study's atezo-bev group was analyzed. PR or SD per RECIST v1.1 lasting more than 6 months defined as durable. For histologic analysis, a comparable real-world from Japan Taiwan who had undergone...
Markers that could accurately predict responses to the general kinase inhibitor sorafenib are needed better leverage its clinical applications. In this study, we examined a hypothesized role in drug response for growth arrest DNA damage-inducible gene 45β (GADD45β), which is commonly underexpressed hepatocellular carcinoma (HCC) where may offer an important new therapeutic option. The anticancer activity of sorafenib-induced GADD45β expression was tested panel HCC cell lines and xenograft...
Immune checkpoint blockade has shown promising antitumor activity against a variety of tumor types. However, responses in castration-resistant prostate cancer remain relatively rare—potentially due to low baseline levels infiltration. Using an immunocompetent cMyc-driven model (Myc-CaP), we sought understand the immune infiltrate induced by androgen deprivation therapy (ADT) and leverage that infiltration toward therapeutic benefit. flow cytometry, qPCR IHC, quantified ADT-induced terms cell...
Background Despite long-standing recognition in the significance of mucus overproduction asthma, its etiology remains poorly understood. Muc5ac is a secretory mucin that has been associated with reduced pulmonary function and asthma exacerbations. Objectives We sought to investigate immunological pathway controls expression allergic airway inflammation asthma. Methods Cockroach allergen-induced aryl hydrocarbon receptor (AhR) signaling activation was examined human bronchial epithelial cells...
Lifestyle factors are considered important for the pathogenesis of both nasopharyngeal and oropharyngeal carcinomas. In Taiwan, incidence carcinoma gradually decreased over past 20 years, whereas that increased rapidly. To compare trends carcinomas in age-period-cohort model was used to analyze epidemiologic data from 1981 2000 obtained Taiwan Cancer Registry. The calendar time period 1986 1990 1931 1940 birth cohort were as reference groups estimates relative risk. For carcinoma, seemed...
Allergens have been identified as potential triggers in patients with atopic dermatitis (AD). Patients AD are highly sensitive to cockroach allergen. The underlying mechanism, however, remains undetermined. Here, we established a allergen–induced AD-like mouse model, and demonstrate that repeated exposure allergen led aggravated skin inflammation, characterized by increased type 2 immunity, innate lymphoid cells (ILC2s), mast cells. Increased were also observed AD. Mast cell–deficient mice...