A5101613897- Dermatology and Skin Diseases
- Reproductive System and Pregnancy
- Endometriosis Research and Treatment
- Allergic Rhinitis and Sensitization
- Food Allergy and Anaphylaxis Research
- Prenatal Screening and Diagnostics
- Pregnancy and preeclampsia studies
- Urticaria and Related Conditions
- Asthma and respiratory diseases
- RNA modifications and cancer
- Nutritional Studies and Diet
- Ovarian function and disorders
- Maternal and fetal healthcare
- Mast cells and histamine
- Reproductive Physiology in Livestock
- Obesity, Physical Activity, Diet
- Reproductive Biology and Fertility
- Hepatitis C virus research
- Gout, Hyperuricemia, Uric Acid
- Maternal and Perinatal Health Interventions
- Ectopic Pregnancy Diagnosis and Management
- Neonatal Respiratory Health Research
- Cancer Risks and Factors
- Assisted Reproductive Technology and Twin Pregnancy
- Autophagy in Disease and Therapy
Guangzhou Medical University
2017-2025
Children's Hospital of Chongqing Medical University
2015-2025
Chongqing Medical University
2015-2025
Community Link
2025
First Affiliated Hospital of Xinjiang Medical University
2025
Xinjiang Medical University
2025
Third Affiliated Hospital of Guangzhou Medical University
2017-2024
Soochow University
2022-2024
University of Glasgow
2024
Kunming Medical University
2020-2023
Dupilumab is a safe and effective treatment for moderate to severe atopic dermatitis (AD), but real-world data in pediatric patients China are limited. Currently, there no exploration of changes blood cell counts derived indexes patients, especially under 6 years old. To investigate the before after dupilumab Chinese children with AD, relationship clinical scores, potential role these on efficacy. We conducted retrospective study 109 AD treated dupilumab. Derived inflammatory indexes,...
The objective of this study was to develop a Chinese Healthy Eating Index (CHEI) based on the updated Dietary Guidelines for (DGC-2016) and apply it in 2011 China Health Nutrition Survey (CHNS-2011) assess diet quality its association with typical sociodemographic/economic factors. Data from 14,584 participants (≥2 years) CHNS-2011, including three 24-h dietary recalls additional variables, were used CHEI. standard portion size applied quantify food consumption. CHEI designed as continuous...
Successful pregnancy involves the homeostasis between maternal decidua and fetoplacental units, whose disruption contributes to compromised outcomes, including recurrent spontaneous abortion (RSA). The role of cell heterogeneity in RSA is yet be illustrated.A total 66,078 single cells from samples isolated patients with healthy controls were analysed by unbiased single-cell RNA sequencing (scRNA-seq).Our scRNA-seq results revealed that stromal are most abundant type during early pregnancy....
Background: Increased Nuchal Translucency (NT) is an important biomarker associated with increased risk of fetal structural anomalies. It known to be contributed by a wide range genetic etiologies from single nucleotide variants those affecting millions base-pairs. Currently, prenatal diagnosis routinely performed karyotyping and chromosomal microarray analysis (CMA), however, both them have limited resolution. The diversity the warrants integrated assay such as genome sequencing (GS) for...
The Chinese Healthy Eating Index (CHEI) is a measuring instrument of diet quality in accordance with the Dietary Guidelines for (DGC)-2016. objective study was to evaluate validity and reliability CHEI. Data from 12,473 adults China Health Nutrition Survey (CHNS)-2011, including 3-day–24-h dietary recalls were used this study. CHEI assessed by four exemplary menus developed DGC-2016, general linear models, independent t-test Mann–Whitney U-test, Spearman’s correlation analysis, principal...
Recurrent miscarriage (RM) is a distressing pregnancy complication. While the etiology of RM remains unclear, growing evidence has indicated relevance trophoblast impairment to pathogenesis RM. PR-SET7 sole enzyme catalyzing monomethylation H4K20 (H4K20me1) and been implicated in many pathophysiological processes. However, how functions trophoblasts its remain unknown. Here, we found that trophoblast-specific loss Pr-set7 mice led defective trophoblasts, resulting early embryonic loss....
Previous studies on alcohol consumption and incident gout have mostly included men or combined both sexes, the sex-specific associations between are poorly understood.
The establishment of pregnancy in human necessitates appropriate decidualization stromal cells, which involves steroids regulated periodic transformation endometrial cells during the menstrual cycle. However, potential molecular regulatory mechanism underlying initiation and maintenance humans is yet to be fully elucidated. In this investigation, we document that SOX4 a key regulator by directly regulating FOXO1 expression as revealed whole genomic binding assay RNA sequencing. Besides, our...
Allergens have been identified as potential triggers in patients with atopic dermatitis (AD). Patients AD are highly sensitive to cockroach allergen. The underlying mechanism, however, remains undetermined. Here, we established a allergen–induced AD-like mouse model, and demonstrate that repeated exposure allergen led aggravated skin inflammation, characterized by increased type 2 immunity, innate lymphoid cells (ILC2s), mast cells. Increased were also observed AD. Mast cell–deficient mice...
Human uterine stromal cell undergoes decidualization for pregnancy establishment and maintenance, which involved extensive proliferation differentiation. Increasing studies have suggested that recurrent spontaneous abortion (RSA) may result from defective endometrial decidualization. However, the critical molecular mechanisms underlying impaired during RSA are still elusive. By using our recently published single-cell RNA sequencing (scRNA-seq) atlas, we found MYC-associated factor X (MAX)...
Vitamin A deficiency (VAD) has been hypothesized to play a role in the pathophysiology of atopic dermatitis (AD).We sought verify whether VAD can exacerbate AD development, and explore possible pathophysiologic mechanism.We detected serum vitamin (VA) concentration different phenotypes infants (intrinsic AD, iAD extrinsic eAD), established ovalbumin (OVA) percutaneous sensitized model passive cutaneous anaphylaxis (PCA) on supplementation (VAS) wild-type mice (C57BL/6) both normal VA (VAN)...
Background: Whether lifestyle factors are similarly associated with risk of heart failure (HF) for individuals different metabolic or genetic status remains unclear. Methods: We included 464 483 participants from UK Biobank who were free major cardiovascular disease HF during baseline recruitment. Healthy avoidance smoking, no obesity, regular physical activity, and healthy diet. Lifestyle was categorized as favorable (3 4 factors), intermediate (2 unfavorable (0 1 factor) lifestyles....
Background The real-world experience of dupilumab in Chinese is limited, and the initial loading dose has not yet been deeply explored patients aged <6 years. Objective To explore efficacy safety with moderate-to-severe atopic dermatitis investigate effect higher for disease control Methods A total 155 were divided into three groups according to age: years, 6-11 >11 Among 37 received a high 300 mg body weight <15kg or 600 ≥15kg, another standard 200 ≥15kg. Multiple...
Guidelines and interventions highlighting the importance of increasing intake minimally-processed, fiber-rich plant foods may promote health longevity across diverse glycemic groups.
Defects in decidual response are associated with adverse pregnancy outcomes which includes recurrent loss (RPL). It is reported that cellular senescence happens during decidualization and pro-senescent the luteal phase endometrium related to RPL. However, underlying mechanisms of how excessive takes place RPL decidua cells remain largely unexplored. The senescent phenotype tumor necrosis factor receptor 1(TNFR1) expression were analyzed by using our previously published single-cell...