A5100715404- Reproductive System and Pregnancy
- Galectins and Cancer Biology
- Pregnancy and preeclampsia studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Aquaculture disease management and microbiota
- Endometriosis Research and Treatment
- Immune Response and Inflammation
- Toxin Mechanisms and Immunotoxins
- Respiratory Support and Mechanisms
- Birth, Development, and Health
- Plant Virus Research Studies
- Photosynthetic Processes and Mechanisms
- Gestational Diabetes Research and Management
- RNA modifications and cancer
- Identification and Quantification in Food
- Trypanosoma species research and implications
- Neonatal Respiratory Health Research
- Plant Stress Responses and Tolerance
- Vector-borne infectious diseases
- Influenza Virus Research Studies
- Biochemical Acid Research Studies
- Biochemical and Structural Characterization
- Nitric Oxide and Endothelin Effects
- Inflammasome and immune disorders
- Phagocytosis and Immune Regulation
Shanghai Jiao Tong University
2025
University of South China
2025
Dalian Medical University
2015-2024
Xian Central Hospital
2024
Nanning Normal University
2024
Hunan Agricultural University
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2022
National Health and Family Planning Commission
2022
Central South University
2016-2021
China-Japan Friendship Hospital
2020
Abstract Neutrophil extracellular traps (NETs) facilitate the killing of pathogens. However, excessive NETs formation and poor degradation are associated with exacerbated immune responses tissue injury. In this study, we investigated role in lipopolysaccharide (LPS)-mediated acute lung injury (ALI) assessed use DNase I, for treatment ALI. Additionally, focused on controversial issue whether LPS directly induces release vitro . was detected murine ALI vivo increased markers,...
Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a manifestation of systemic inflammation in the lungs, but factors that trigger ALI/ARDS are unclear. We hypothesized neutrophil extracellular traps (NETs) contribute to pathogenesis acid aspiration-induced ALI/ARDS.Analysis bronchial aspirates from ARDS patients showed NETs were significantly correlated with degree (r = -0.5846, p 0.0359). bronchoalveolar lavage fluid acid-aspiration mice higher (141.6 ± 23.08) at 3 h after...
Cell-mediated immune responses play important roles in protection against Plasmodium infection. However, impaired immunity, such as lymphocyte exhaustion, is a common phenomenon malaria. T-cell immunoglobulin– and mucin-domain–containing molecule 3 (Tim-3) an regulatory cell-mediated immunity has been implicated In this study, it was found that Tim-3 expression on key populations of lymphocytes significantly increased both falciparum–infected patients berghei ANKA (PbANKA)–infected C57BL/6...
Abstract Glycosylation alters the molecular and functional features of glycoproteins, which is closely related with many physiological processes diseases. During “window implantation”, uterine endometrium transforms into a receptive status to accept embryo, thereby establishing successful embryo implantation. In this article, we aimed at investigating role N‐glycosylation, major modification type in process endometrial receptivity establishment. Results found that human tissues mid‐secretory...
Endometrial stromal cell decidualization is critical for embryo implantation. Dysfunctional leads to implantation failure, miscarriage and even pregnancy associated disorders in subsequent trimesters. Protein glycosylation involved many physiological pathological processes. O-fucosyltransferase 1 (poFUT1) the key enzyme O-fucosylation of proteins. However, role mechanism poFUT1 human endometrial remain elusive.We employed immunohistochemistry detect level uterine endometrium from those...
T cell immunoglobulin- and mucin-domain-containing molecule 3 (Tim-3) has been regarded as an important regulatory factor in both adaptive innate immunity. Recently, Tim-3 was reported to be involved Th2-biased immune responses mice infected with Schistosoma japonicum, but the exact mechanism behind involvement of remains unknown. The present study aims understand role response against S. japonicum infection. expression determined by flow cytometry, increased observed on CD4(+) CD8(+) cells,...
Abstract Objectives The transformation of cytotrophoblasts into mesenchymal‐like extravillous trophoblasts is necessary for successful embryo implantation, and the inadequate may cause abortion. Epiregulin, which a new growth factor, plays important roles in reproductive processes. glycosylation many proteins reproduction processes critical. Protein O‐fucosyltransferase 1 (poFUT1) key enzyme biosynthesis O‐fucosylation on specific glycoproteins. Urokinase‐type plasminogen activator (uPA)...
T-cell immunoglobulin- and mucin-domain-containing molecule 3 (Tim-3) has complicated roles in regulating monocytes macrophages various diseases it tends to be an inhibitory facilitate the immune escape of parasites malaria. However, mechanisms Tim-3 mediated responses malaria have not been clear. In this study, we found that Plasmodium infection down-regulated expression peripheral patients suffering from falciparum splenic berghei ANKA-infected mice. signal blockade with anti-Tim-3...
As a severe complication of influenza infection, acute respiratory distress syndrome (ARDS) has higher morbidity and mortality. Although IL-36γ been proven to promote inflammation at epithelial sites protect against specific pathogen the detailed roles in infection remain poorly understood. In this study, we have found that expression is influenza-induced ARDS patients than healthy individuals. was induced human lung cells peripheral blood mononuclear by Influenza A virus (IAV) its induction...
Candida species (Candida spp.) are important fungal pathogens, which cause numerous clinical diseases associated with significant mortality and morbidity in healthcare settings. In our previous study, we identified a recombinant peptide, chromogranin A (CGA)-N46, corresponding to the N-terminal Pro31-Gln76 sequence of human CGA, that exhibited antifungal activity against albicans. The present study investigated CGA-N46, its underlying mechanism, spp. CGA-N46 inhibited growth all tested spp.,...
Peritoneal metastasis is the main cause of poor prognoses and high mortality in ovarian cancer patients. Abnormal protein glycosylation modification associated with malignancy. Elevated α1,3-mannosyltransferase 3 (ALG3), which catalyzes α1,3-mannosylation glycoproteins, has been found some malignant tumors. However, pathological significance ALG3 its regulatory mechanism unclear. The results showed that level ALG3/α1,3-mannosylation was higher human tissues compared normal tissues, as...
Endometrial decidualization is critical to successful uterine receptivity and embryo implantation. Dysfunction of associated with some pregnancy-related disorders, including miscarriage. Protein glycosylation involved in many physiological pathological processes. O-fucosyltransferase 1 (poFUT1) a key enzyme responsible for O-fucosylation biosynthesis on glycoproteins. Bone morphogenetic protein (BMP1) an essential glycoprotein reproduction. However, the role molecular mechanism fucosylated...
The Chinese soft-shelled turtle ( Pelodiscus sinensis ) has become increasingly susceptible to frequent diseases with the intensification of farming, which severely impacts development aquaculture industry. Sodium butyrate (SB) is widely used as a feed additive due its promotion growth, enhancement immune function, and antioxidative properties. This study aimed investigate effects dietary SB on growth performance, intestinal microflora turtles. A total 300 turtles (mean weight: 11.36 ±...
The proliferation and adhesion abilities of placental trophoblasts are critical for embryo implantation successful pregnancy. Protein O-fucosyltransferase 1 (poFUT1) the transcription factor c-Fos/c-Jun have been found to promote trophoblastic cell invade into endometrium. Progesterone is regulation embryonic implantation. However, exact role poFUT1 in endometrium, relationship between progesterone, c-Fos/c-Jun, has not studied detail. In current study, we that serum levels progesterone...