A5100423610- Inflammasome and immune disorders
- Respiratory Support and Mechanisms
- COVID-19 Clinical Research Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Intensive Care Unit Cognitive Disorders
- Reproductive tract infections research
- Sepsis Diagnosis and Treatment
- Phagocytosis and Immune Regulation
- Cervical Cancer and HPV Research
- Kawasaki Disease and Coronary Complications
- Hematological disorders and diagnostics
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Respiratory viral infections research
- Pancreatitis Pathology and Treatment
- Biosensors and Analytical Detection
- Heme Oxygenase-1 and Carbon Monoxide
- Genital Health and Disease
- Autophagy in Disease and Therapy
- Airway Management and Intubation Techniques
- Immune cells in cancer
- Antimicrobial Peptides and Activities
- Sirtuins and Resveratrol in Medicine
- Mitochondrial Function and Pathology
- Immune Response and Inflammation
Central South University
2017-2024
Xiangya Hospital Central South University
2017-2024
UCB Pharma (United States)
2023
Weatherford College
2021
Northwest A&F University
2020
Henan University
2020
Shandong University
2020
Chinese Academy of Agricultural Sciences
2020
Dali University
2020
Biogas Institute of Ministry of Agriculture
2020
Uncontrollable inflammation is a critical feature of gram-negative bacterial pneumonia-induced acute respiratory distress syndrome (ARDS). Both neutrophils and alveolar macrophages participate in inflammation, but how their interaction augments triggers ARDS unclear. The authors hypothesize that neutrophil extracellular traps (NETs), which are formed during NETosis, partly cause macrophage pyroptosis worsen the severity ARDS. first analysed whether NETs caspase-1 involved clinical cases...
The role of NOD-like receptor protein 3 (NLRP3)-mediated macrophages pyroptosis in acute lung injury (ALI) is well-established. Quercetin (Que) a natural bioflavonoid compound with anti-inflammatory and antioxidative properties that reportedly inhibits the NLRP3 inflammasome sepsis-induced organ dysfunctions such as ALI. However, mechanism underlying inhibitory effect quercetin on activation remains unclear. In this study, we established an endotoxin-induced ALI mouse model vitro LPS...
Early identification of patients with severe coronavirus disease (COVID-19) at an increased risk progression may promote more individualized treatment schemes and optimize the use medical resources. This study is aimed investigating utility C-reactive protein to albumin (CRP/Alb) ratio for early stratification patients.We retrospectively reviewed 557 COVID-19 confirmed outcomes (discharged or deceased) admitted West Court Union Hospital, Wuhan, China, between January 29, 2020 April 8, 2020....
Abstract Background Acute respiratory distress syndrome (ARDS) is a neutrophil-associated disease. Delayed neutrophil apoptosis and increased levels of extracellular traps (NETs) have been described in ARDS. We aimed to investigate the relationship between these phenomena their potential as inflammation drivers. hypothesized that delayed might enhance NET formation Method Our research was carried out three aspects: clinical research, animal experiments, vitro experiments. First, we compared...
The aim of this study was to investigate the effect resveratrol (RSV) on cigarette smoke extract (CSE)-induced cell apoptosis and mitochondrial dysfunction in vitro, as well changes MFN2 expression level.Cultured human bronchial epithelial (HBE) cells were initially treated with CSE induce apoptosis, followed by incubation either or without RSV. Numerous techniques used evaluate outcomes present study, including a counting kit-8 assay, real-time quantitative polymerase chain reaction...
Pneumonia caused by Chlamydia psittaci is a significant global public health issue. Symptom onset and laboratory characteristics may be confused with those of other respiratory viral infections, including adenovirus pneumonia. We aimed to determine differences in clinical presentations establish simple nomogram differentiate C. pneumonias.We conducted multicenter retrospective study 10 tertiary general hospitals compare patients either (n = 78) or 102) A multivariable logistic regression...
Chlamydia psittaci pneumonia (CPP) exhibits similar characteristics as of COVID-19 with respect to clustering outbreaks and onset symptoms. This study is aimed at exploring the different clinical manifestations both pneumonias establish a simple nomogram distinguish them. multicenter, retrospective, case–control compared two independent cohorts patients CPP or COVID-19. The risk factors were analyzed using multivariate logistic regression, which was used nomogram. Both exhibited As COVID-19,...
Among patients with psoriasis (PSO), the diagnosis and treatment patterns of psoriatic arthritis (PsA) differ depending on managing-physician's specialty. ObjectivesTo estimate incidence of, time to, factors associated PsA after incident PSO diagnosis.To evaluate disease management pattern, by physician specialty, 1 year before among PsA. Methods• Data were extracted from HealthVerity Claims, Pharmacy, Electronic Medical Record (EMR) database, November 2015-August 2022, for insured (≥18...