A5017826942- Nasolacrimal Duct Obstruction Treatments
- Cancer-related molecular mechanisms research
- COVID-19 Clinical Research Studies
- Congenital Ear and Nasal Anomalies
- Cancer and Skin Lesions
- Stress Responses and Cortisol
- MicroRNA in disease regulation
- Lung Cancer Treatments and Mutations
- vaccines and immunoinformatics approaches
- Long-Term Effects of COVID-19
- Head and Neck Surgical Oncology
- Ocular Surface and Contact Lens
- RNA modifications and cancer
- Circular RNAs in diseases
- Glaucoma and retinal disorders
- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Neuroendocrine regulation and behavior
- Reproductive Health and Technologies
- RNA Research and Splicing
- Inflammatory mediators and NSAID effects
- Ophthalmology and Eye Disorders
- Antibiotic Resistance in Bacteria
- Demographic Trends and Gender Preferences
- Retinoids in leukemia and cellular processes
Central South University
2016-2025
Shanxi Academy of Medical Sciences
2025
Shanxi Medical University
2025
Xiangya Hospital Central South University
2020-2024
Hunan Provincial Center for Disease Control and Prevention
2022-2024
Capital Medical University
2014-2024
Beijing Children’s Hospital
2014-2024
National Clinical Research Center for Digestive Diseases
2022-2023
University of North Carolina at Chapel Hill
2023
First Affiliated Hospital of Xinxiang Medical University
2010-2022
Alveolar epithelial cell damage is an important determinant of the severity acute lung injury/acute respiratory distress syndrome (ALI/ARDS). However, molecular mechanisms alveolar death during development ALI/ARDS remain unclear. In this study, we explore role miR-29a-3p in and its mechanism. Plasma samples were collected from healthy controls ARDS patients. Mice intratracheally instilled with lipopolysaccharide (LPS) to establish injury. N6-adenosine (m6A) quantification, RNA-binding...
Background Nocardia genus, a complex group of species classified to be aerobic actinomycete, can lead severe concurrent infection as well disseminated infection, typically in immunocompromised patients. With the expansion susceptible population, incidence has been gradually growing, accompanied by increased resistance pathogen existing therapeutics. However, there is no effective vaccine against this yet. In study, multi-epitope was designed using reverse vaccinology combined with...
Human metapneumovirus (HMPV) is one of the main pathogens causing severe respiratory infections in children, as a common cause immunodeficiency-related deaths children and elderly individuals, prevalence HMPV has been showing an increasing trend during last years. However, no vaccines or effective treatment plans are available currently. In this present, based on candidate proteins highly associated with viral virulence promising protective potential, we screened for immunodominant cytotoxic...
Abstract Background The prevalence of carbapenem-resistant Klebsiella pneumoniae bloodstream infection (CRKP-BSI) is increasing worldwide. CRKP-BSI associated with high rates morbidity and mortality due to limited antibiotic choices. Here, we aim identify the risk factors for CRKP BSI. Methods This was a retrospective study past data from January 1st, 2012 December 31st, 2019 adult patients KP-BSI in Xiangya Hospital, China. Results Among 706 incidences included this study, 27.4% them...
ABSTRACT Background The 2019 novel coronavirus disease (COVID-19) emerged in Wuhan, Hubei province, China, and was characterized as pandemic by the World Health Organization. Diabetes mellitus is an established risk factor for poor clinical outcomes, but association of diabetes with prognosis COVID-19 have not been reported yet. Methods In this cohort study, we retrospectively reviewed 258 consecutive hospitalized patients or without at West Court Union Hospital Huazhong University Science...
Pulmonary delivery of anti-inflammatory siRNA presents a promising approach for localized therapy acute lung injury (ALI), while polycationic vectors can be easily trapped by the negatively charged airway mucin glycoproteins and arbitrarily internalized epithelial cells with nontargetability immunological clearance. Herein, we report material, dopamine (DA)-grafted hyaluronic acid (HA-DA), coating on an anti-TNF-α vector to address these limitations. HA-DA was simply synthesized facilely...
Abstract Background Acute respiratory distress syndrome (ARDS) is a neutrophil-associated disease. Delayed neutrophil apoptosis and increased levels of extracellular traps (NETs) have been described in ARDS. We aimed to investigate the relationship between these phenomena their potential as inflammation drivers. hypothesized that delayed might enhance NET formation Method Our research was carried out three aspects: clinical research, animal experiments, vitro experiments. First, we compared...
Abstract Glioma is the most frequent primary brain tumor. Recently, upregulation of microRNA (miR)-23a was found to be associated with glioma, but molecular mechanism by which miR-23a promotes glioma growth remains unveiled. In present study, we that significantly upregulated in tissues compared their matched adjacent tissues. also highly expressed cell lines SHG44, U251 and U87 cells. Moreover, identified homeobox D10 (HOXD10) as a novel target for miR-23a. The expression HOXD10 reduced...
Mcl-1, an anti-apoptotic Bcl-2 family member, is often overexpressed in non-small cell lung cancer (NSCLC). Bufalin has been reported to induce apoptosis various tumor cells. However, there no report showing that bufalin could downregulate Mcl-1 expression NSCLC.Cell proliferation was analyzed by counting kit-8 (CCK-8) assay H1975 Cell detected flow cytometry. mRNA RT-PCR. The of apoptosis-associated proteins cells western blotting. levels ubiquitination and NOXA were Immunoprecipitation...
Rheumatoid arthritis (RA) is the most frequently occurring inflammatory arthritis. The present study was performed to characterize role of microRNA-101-3p (miR-101-3p) and prostaglandin-endoperoxide synthase 2 (PTGS2) in inflammation biological activities fibroblast-like synoviocytes (FLSs) RA.Initially, miR-101-3p PTGS2 expression RA tissues patients rats detected by qRT-PCR Western blot analysis. Rat model type II collagen-induced (CIA) adopted simulate RA, followed injection mimics or...
Elderly patients with coronavirus disease 2019 (COVID-19) are more likely to develop severe or critical pneumonia, a high fatality rate. To date, there is no model predict the severity of COVID-19 in elderly patients. In this study, who maintained non-severe condition and progressed during hospitalization were assigned groups, respectively. Based on admission data these two groups training cohort, albumin (odds ratio [OR] = 0.871, 95% confidence interval [CI]: 0.809 - 0.937, P < 0.001),...
Sepsis-associated encephalopathy (SAE) is a risk factor for cognitive and memory dysfunction; however, the mechanism remains unclear. Brain-derived neurotrophic (BDNF) was reported to have positive effect on cognition emotion regulation, but study of its precursor, proBDNF, has been limited. This aimed elucidate effects associated mechanisms hippocampal proBDNF in lipopolysaccharide (LPS)-induced SAE mouse model. In this study, we found that mice exhibited dysfunction day 7 after LPS...
Objective: To identify potential predictors for invasive and non-invasive mechanical ventilation in coronavirus disease 2019 (COVID-19) patients. Methods: This study retrospectively analyzes data of 516 patients with confirmed COVID-19, who were categorized into three groups based on which method was used during the hospitalization period. Results: Among cases 446 did not receive ventilation, 38 received (IMV) 32 (NIMV). The median age included 61 years old (interquartile range, 52–69). A...
Two new dyes, consisting of an aromatic amine donor and dansyl acceptor connected by Diels–Alder bonds, display a switchable energy transfer. Dynamic covalent properties enable the mutual conversion two dyes maleimide exchanges.
Patients suffering from sepsis-induced acute lung injury (ALI) exhibit a high mortality rate, and their prognosis is closely associated with infiltration of neutrophils into the lungs. In this study, we found significant elevation CD64
MiR-150 regulates maturation and differentiation of T cells but how it functions in multiple sclerosis (MS) is unclear. In miR-150 knockout (KO) mice, we examined the effect deletion on disease severity experimental autoimmune encephalomyelitis (EAE), an animal model MS. After deleting miR-150, EAE was reduced according to clinical score. Histological staining MBP immunofluorescence revealed that limited extent inflammatory demyelination axonal damage spinal cord. Flow cytometry showed CD3+,...