A5100610320- Landslides and related hazards
- Cryospheric studies and observations
- Synthetic Aperture Radar (SAR) Applications and Techniques
- Climate change and permafrost
- Sphingolipid Metabolism and Signaling
- Advanced Vision and Imaging
- Arctic and Antarctic ice dynamics
- Remote Sensing in Agriculture
- Gastric Cancer Management and Outcomes
- Epigenetics and DNA Methylation
- Innovative concrete reinforcement materials
- Immune cells in cancer
- Robotics and Sensor-Based Localization
- RNA modifications and cancer
- 3D Surveying and Cultural Heritage
- Liver Disease Diagnosis and Treatment
- Concrete and Cement Materials Research
- Flood Risk Assessment and Management
- Adipose Tissue and Metabolism
- Immune Cell Function and Interaction
- Advanced Image and Video Retrieval Techniques
- Remote-Sensing Image Classification
- Remote Sensing and LiDAR Applications
- IL-33, ST2, and ILC Pathways
- Geotechnical Engineering and Underground Structures
Tongji University
2016-2025
Minzu University of China
2024-2025
Can Tho University
2025
Fudan University Shanghai Cancer Center
2024
Shanghai Medical College of Fudan University
2016-2024
Medical University of South Carolina
2013-2024
Kunming Metallurgy College
2013-2024
China Mobile (China)
2020-2024
State Key Laboratory of Mobile Networks and Mobile Multimedia Technology
2020-2024
Huazhong University of Science and Technology
2024
Significance Although exercise is a well known and potent stimulus for new bone formation, weightlessness or muscle loss characteristically cause loss, it has remained unclear how talks to bone, despite their close proximity. Here, we show that molecule irisin derived from skeletal in response profound effects enhancing mass improving the geometry strength specifically of cortical key function which resist bending torsion. Trabecular reservoir bodily calcium, remarkably spared. Irisin may...
Post-event Interferometric Synthetic Aperture Radar (InSAR) analysis on a stack of 45 C-band SAR images acquired by the ESA Sentinel-1 satellites from 9 October 2014 to 19 June 2017 allowed identification clear precursory deformation signal for Maoxian landslide (Mao County, Sichuan Province, China). The occurred in early morning 24 and killed more than 100 people village Xinmo. have been processed through an advanced multi-interferogram capable maximising density measurement points,...
The current availability of advanced remote sensing technologies in the field landslide analysis allows for rapid and easily updatable data acquisitions, improving traditional capabilities detection, mapping monitoring, as well optimizing fieldwork investigating hazardous or inaccessible areas, while granting at same time safety operators. Among Earth Observation (EO) techniques last decades optical Very High Resolution (VHR) Synthetic Aperture Radar (SAR) imagery represent very effective...
A complete multitemporal landslide inventory, ideally updated after each major event, is essential for quantitative hazard assessment. However, traditional mapping methods, which rely on manual interpretation of aerial photographs and intensive field surveys, are time consuming not efficient generating such event-based inventories. In this letter, a semi-automatic approach based object-oriented change detection rapid using very high resolution optical images introduced. The usefulness...
The NLRP3 inflammasome is a multiprotein complex that protects hosts against variety of pathogens. However, the molecular mechanisms modulating activation, especially at priming step, are still poorly understood. This study was designed to elucidate negative regulation nuclear factor E2-related factor-2 (Nrf2) on activation inflammasome.We reported Nrf2 inhibited expression, caspase-1 cleavage, and subsequent IL-1β generation. Compared with normal cells, Nrf2-deficient cells showed...
Accurate landslide inventory mapping is essential for quantitative hazard and risk assessment. Although multi-temporal change detection techniques have contributed greatly to preparation, it still challenging generate quality images (CDIs) accurate mapping. The recently proposed detection-based Markov random field (CDMRF) provides an effective approach rapid of landslides with minimum user interventions. However, when CDI generated by vector analysis (CVA) alone, the CDMRF method may suffer...
Abstract Lung adenocarcinoma (LUAD) harboring EGFR mutations prevails in Asian population. However, the inter-patient and intra-tumor heterogeneity has not been addressed at single-cell resolution. Here we performed RNA sequencing (scRNA-seq) of total 125,674 cells from seven stage-I/II LUAD samples five tumor-adjacent lung tissues. We identified diverse cell types within tumor microenvironment (TME) which myeloid T were most abundant stromal tumors adjacent Within tumors, accompanied by an...
Chemoresistance presents a major obstacle to the efficacy of chemotherapeutic treatment cancers. Using drugs select drug-resistant cancer cells in hepatocellular carcinoma (HCC) and several other cell lines, we demonstrate that chemoresistant displayed stem features, such as increased self-renewal ability, motility, multiple drug resistance, tumorigenicity. Octamer 4 (Oct4) messenger RNA (mRNA) levels were dramatically due DNA demethylation regulation Oct4. By functional study, Oct4...
The immune response that is characteristic of parasitic helminth infections includes components associated with immediate-type hypersensitivity: elevated serum IgE, eosinophilia, and intestinal mast cell hyperplasia. In infection the nematode, Heligmosomoides polygyrus, IL-4 mediates protective immunity, suggesting presence a host-protective Th2 response. this investigation, we examined early stages responsiveness to H. polygyrus determine whether at what stage specific Th2-like pattern...
We compared concurrent combination chemotherapy and radiotherapy with surgery adjuvant in patients stage III/IV nonmetastatic squamous cell head neck cancer. Patients non-nasopharyngeal nonsalivary resectable cancer were randomised to receive either followed by (60 Gy over 30 fractions) or (66 33 fractions). Combination comprised two cycles of i.v. cisplatin 20 mg m− 2 day− 1 5-fluorouracil 1000 1, both run 96 h given on days 28 the radiotherapy. A total 119 randomised. At a median follow-up...
The synthetic aperture radar (SAR) interferometry (InSAR) technique has already shown its importance in landslide mapping and monitoring applications. However, the usefulness of traditional differential InSAR applications is limited by disturbing factors such as temporal decorrelation atmospheric disturbances. Persistent Scatterers Interferometry (PSI) a recently developed approach. It generates stable benchmarks (namely persistent scatterers, PSI point targets) using multi-interferogram...
Significance In this study, we show that a primitive brain hormone, arginine vasopressin (AVP), which has hitherto been implicated in regulating water balance mammals, function skeletal homeostasis. Using genetically modified mice are lacking one of the AVP receptors as well pharmacologic inhibitors, negatively regulates osteoblasts (cells form new bone) and stimulates osteoclasts remove old bone). Our findings explain bone loss is known to accompany low blood sodium levels patients when high.
Smoking is a major risk factor for osteoporosis and fracture, but the mechanism through which smoke causes bone loss remains unclear. Here, we show that toxins benzo(a)pyrene (BaP) 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) interact with aryl hydrocarbon receptor (Ahr) to induce osteoclastic resorption activation of cytochrome P450 1a/1b (Cyp1) enzymes. BaP TCDD enhanced osteoclast formation in marrow cell cultures gavage stimulated osteoclastogenesis vivo. The triggered by or RANK-L was...
Escape of prostate cancer (PCa) cells from ionizing radiation-induced (IR-induced) killing leads to disease progression and relapse. The influence sphingolipids, such as ceramide its metabolite sphingosine 1-phosphate, on signal transduction pathways under cell stress is important survival adaptation responses. In this study, we demonstrate that ceramide-deacylating enzyme acid ceramidase (AC) was preferentially upregulated in irradiated PCa cells. Radiation-induced AC gene transactivation...
Significance Type 1 Gaucher disease (GD1) is a rare autosomal recessive disorder caused by inherited mutations in the glucocerebrosidase ( GBA1 ) gene. This results marked accumulation of glycosphingolipid substrates, causing visceromegaly, cytopenia, and osteopenia. Here, we have rescued this clinical phenotype GD1 mice genetically deleting Gba2 , gene encoding downstream extralysosomal enzyme, GBA2. We also report that sphingosine production patients may contribute to low-turnover bone...