A5030275398- Genetic Associations and Epidemiology
- Bioinformatics and Genomic Networks
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Genetic Mapping and Diversity in Plants and Animals
- Genetic and phenotypic traits in livestock
- Health, Environment, Cognitive Aging
- RNA regulation and disease
- Gene expression and cancer classification
- Mosquito-borne diseases and control
- COVID-19 epidemiological studies
- Glaucoma and retinal disorders
- Genetics and Neurodevelopmental Disorders
- RNA modifications and cancer
- Advanced MRI Techniques and Applications
- Retinal Development and Disorders
- Folate and B Vitamins Research
- Statistical Methods and Inference
- Dementia and Cognitive Impairment Research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Malaria Research and Control
- Genetics, Aging, and Longevity in Model Organisms
- Genomics and Rare Diseases
- Educational Technology and Pedagogy
- Artificial Intelligence in Healthcare
University of Pennsylvania
2022-2025
California University of Pennsylvania
2022-2025
Purdue University West Lafayette
2021-2023
Jilin University
2023
Applied Mathematics (United States)
2023
University of North Carolina at Chapel Hill
2017-2022
University of Minnesota
2022
University of North Carolina Health Care
2021
University of Florida
2016
Baotou Teachers College
2013
Connecting the dots on white matter The of brain, which is composed axonal tracts connecting different brain regions, plays key roles in both normal function and a variety neurological disorders. Zhao et al. combined detailed magnetic resonance imaging–based assessment structures with genetic data nearly 44,000 individuals (see Perspective by Filley). On basis this comprehensive analysis, authors identified structural abnormalities associated psychiatric disorders, as well some nondisease...
Cardiovascular health interacts with cognitive and mental in complex ways, yet little is known about the phenotypic genetic links of heart-brain systems. We quantified connections using multiorgan magnetic resonance imaging (MRI) data from more than 40,000 subjects. Heart MRI traits displayed numerous association patterns brain gray matter morphometry, white microstructure, functional networks. identified 80 associated genomic loci (
Abstract The complex biological mechanisms underlying human brain aging remain incompletely understood. This study investigated the genetic architecture of three age gaps (BAG) derived from gray matter volume (GM-BAG), white microstructure (WM-BAG), and functional connectivity (FC-BAG). We identified sixteen genomic loci that reached genome-wide significance (P-value < 5×10 −8 ). A gene-drug-disease network highlighted genes linked to GM-BAG for treating neurodegenerative neuropsychiatric...
Abstract The retina, an anatomical extension of the brain, forms physiological connections with visual cortex brain. Although retinal structures offer a unique opportunity to assess brain disorders, their relationship structure and function is not well understood. In this study, we conducted systematic cross-organ genetic architecture analysis eye-brain using imaging endophenotypes. We identified novel phenotypic links between biomarkers measures from multimodal magnetic resonance (MRI),...
Dengue, a viral disease transmitted by Aedes mosquitoes, is an important public health concern throughout Thailand. Climate variables are potential predictors of dengue transmission. Associations between climate and have usually been performed on large-scale first-level national administrative divisions, i.e. provinces. Here we analyze data finer spatial resolution in one province, which often more relevant for effective control design. The objective this study was to investigate the effect...
Genes on the X chromosome are extensively expressed in human brain. However, little is known for chromosome’s impact brain anatomy, microstructure, and functional networks. We examined 1045 complex imaging traits from 38,529 participants UK Biobank. unveiled potential autosome–X interactions while proposing an atlas outlining dosage compensation traits. Through extensive association studies, we identified 72 genome-wide significant trait-locus pairs (including 29 new associations) that share...
Abstract Brain genetics is an active research area. The degree to which genetic variants impact variations in brain structure and function remains largely unknown. We examined the heritability of regional volumes (P ~ 100) captured by single-nucleotide polymorphisms (SNPs) UK Biobank (n 9000). found that are highly heritable this study population common can explain up 80% their variabilities (median 34.8%). observed omnigenic across genome enrichment SNPs chromatin regions. Principal...
Abstract Structural variations of the human brain are heritable and highly polygenic traits, with hundreds associated genes identified in recent genome-wide association studies (GWAS). Transcriptome-wide (TWAS) can both prioritize these GWAS findings also identify additional gene-trait associations. Here we perform cross-tissue TWAS analysis 211 structural neuroimaging discover 278 exceeding Bonferroni significance threshold 1.04 × 10 −8 . The TWAS-significant for structures have been linked...
Severe dengue occurrence has been attributed to increasing age and different virus (DENV) serotypes that cause secondary infections immune-enhancing phenomena. Therefore, we examined if the effect of on severity was mediated by infectivity status while controlling for sex region. Further, assessed spatial clustering individuals with primary infection across Mexican municipalities. Health data from 2012 2017 retrieved Mexico's Ministry Health. A mediation analysis performed using multiple...
Abstract Understanding the genetic basis of biological aging in multi-organ systems is vital for elucidating age-related disease mechanisms and identifying therapeutic interventions. This study characterized architecture age gap (BAG) across nine human organ 377,028 individuals European ancestry from UK Biobank. We discovered 393 genomic loci-BAG pairs (P-value<5×10 -8 ) linked to brain, eye, cardiovascular, hepatic, immune, metabolic, musculoskeletal, pulmonary, renal systems. observed...
Abstract As an anatomical extension of the brain, retina eye is synaptically connected to visual cortex, establishing physiological connections between and brain. Despite unique opportunity retinal structures offer for assessing brain disorders, less known about their relationship structure function. Here we present a systematic cross-organ genetic architecture analysis eye-brain using imaging endophenotypes. Novel phenotypic links were identified biomarkers function measures derived from...
This paper discusses a comparative geographic distribution of Aedes aegypti and albopictus mosquitoes in Mexico, using environmental suitability modeling reported cases arboviral infections.Using presence-only records, we modeled mosquito niches to show how much they influenced the Ae. based on records collected at municipality level. Mosquito surveillance data were used create models regarding predicted mosquitos Mexico.Ae. had relatively better predictive performance (area under curve, AUC...
Physical activity is crucial for human health. With the increasing availability of large-scale mobile health data, strong associations have been found between physical and various diseases. However, accurately capturing this complex relationship challenging, possibly because it varies across different subgroups subjects, especially in datasets. To fill gap, we propose a generalized heterogeneous functional method which simultaneously estimates effects identifies within regression framework....
Abstract Functional magnetic resonance imaging (fMRI) has been widely used to identify brain regions linked critical functions, such as language and vision, detect tumors, strokes, injuries, diseases. It is now known that large sample sizes are necessary for fMRI studies small effect produce reproducible results. Here, we report a systematic association analysis of 647 traits with features extracted from resting-state task-evoked data more than 40,000 UK Biobank participants. We...
To investigate the relationships between longitudinal changes in sleep stages and risk of cognitive decline older men.
Plasma protein levels provide important insights into human disease, yet a comprehensive assessment of plasma proteomics across organs is lacking. Using large-scale multimodal data from the UK Biobank, we integrated with organ imaging to map their phenotypic and genetic links, analyzing 2,923 proteins 1,051 traits multiple organs. We uncovered 5,067 protein-imaging associations, identifying both organ-specific organ-shared proteomic relations, along enriched protein-protein interaction...