A5081417100- Genetic Associations and Epidemiology
- Plant Gene Expression Analysis
- Plant Pathogens and Fungal Diseases
- Bioinformatics and Genomic Networks
- Plant-Microbe Interactions and Immunity
- COVID-19 Clinical Research Studies
- Plant Genetic and Mutation Studies
- RNA modifications and cancer
- Plant biochemistry and biosynthesis
- Plant responses to water stress
- Plant Molecular Biology Research
- SARS-CoV-2 and COVID-19 Research
- Plant tissue culture and regeneration
- Agriculture, Soil, Plant Science
- GABA and Rice Research
- COVID-19 diagnosis using AI
- Ginseng Biological Effects and Applications
- Microbial Metabolism and Applications
- Genetic Mapping and Diversity in Plants and Animals
- Crop Yield and Soil Fertility
- Seedling growth and survival studies
- Plant Pathogenic Bacteria Studies
- Lipid metabolism and biosynthesis
- Plant Stress Responses and Tolerance
- Adipose Tissue and Metabolism
Sun Yat-sen University
2020-2024
Fujian Agriculture and Forestry University
2014-2024
Fudan University
1989-2023
University of Pennsylvania
2023
Zhongnan Hospital of Wuhan University
2020
Wuhan University
2019-2020
Beijing Forestry University
2020
Hunan Agricultural University
2008-2019
AntiCancer (United States)
2019
University of British Columbia
2017
Host-mediated lung inflammation is present1, and drives mortality2, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with may identify mechanistic targets for therapeutic development3. Here we report results of GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study 2,244 critically ill patients COVID-19 from 208 UK intensive care units. We have identified replicated following new significant associations: on...
Interviews with 564 patients stomach cancer and 1,131 controls in an area of China where gastric rates are high revealed a significant reduction risk increasing consumption allium vegetables. Pearsons the highest quartile intake experienced only 40% those lowest. Protective effects were seen for garlic, onions, other allim foods. Although additional research is needed before etiologic inferences can be made, findings consistent recent reports tumor inhibition following administration...
Abstract Objectives Rapid and accurate diagnosis of coronavirus disease 2019 (COVID-19) is critical during the epidemic. We aim to identify differences in CT imaging clinical manifestations between pneumonia patients with without COVID-19, develop validate a diagnostic model for COVID-19 based on radiological semantic features alone. Methods A consecutive cohort 70 66 non-COVID-19 were retrospectively recruited from five institutions. Patients divided into primary ( n = 98) validation 38)...
Abstract The subset of patients who develop critical illness in Covid-19 have extensive inflammation affecting the lungs 1 and are strikingly different from other patients: immunosuppressive therapy benefits critically-ill patients, but may harm some non-critical cases. 2 Since susceptibility to life-threatening infections immune-mediated diseases both strongly heritable traits, we reasoned that host genetic variation identify mechanistic targets for therapeutic development Covid-19. 3...
Most of Camellia oleifera forests have low fruit yield and poor oil quality that are largely associated with soil fertility. Soil physical chemical properties interact each other affecting fertility C. growing under different conditions produced composition. Three main types were studied, redundancy, correlation, double-screening stepwise regression analysis used for exploring the relationships between nutrients uptake properties, shedding light on transport law nutrient elements from root,...
Alfalfa (Medicago sativa) is the most widely grown and important forage crop in world. However, alfalfa susceptible to waterlogging stress, which major constraint for its cultivation area production. So far, molecular mechanism of response largely unknown. Here, comparative transcriptome combined with proteomic analyses two cultivars (M12, tolerant; M25, sensitive) showing contrasting tolerance were performed understand stress. Totally, 748 (581 up- 167 down-regulated) genes differentially...
Abstract Understanding the genetic basis of biological aging in multi-organ systems is vital for elucidating age-related disease mechanisms and identifying therapeutic interventions. This study characterized architecture age gap (BAG) across nine human organ 377,028 individuals European ancestry from UK Biobank. We discovered 393 genomic loci-BAG pairs (P-value<5×10 -8 ) linked to brain, eye, cardiovascular, hepatic, immune, metabolic, musculoskeletal, pulmonary, renal systems. observed...
Abstract Background C. Oleifera is among the world’s largest four woody plants known for their edible oil production, yet contribution rate of improved varieties less than 20%. The species traditional breeding lengthy cycle (20–30 years), occupation land resources, high labor cost, and low accuracy efficiency, which can be enhanced by molecular marker-assisted selection. However, lack high-quality markers hinders genetic analysis breeding. Results Through quantitative traits...
Sweet potato production is constrained by Fusarium wilt, which caused oxysporum f. sp. batatas (Fob). The identification of genes related to disease resistance and the underlying mechanisms will contribute improving via sweet breeding programs. In present study, we performed de novo transcriptome assembly digital gene expression (DGE) profiling challenged with Fob using Illumina HiSeq technology. total, 89,944,188 clean reads were generated from 12 samples assembled into 101,988 unigenes an...
BackgroundGlobally, there have been many cases of coronavirus disease 2019 (COVID-19) among medical staff; however, the main factors associated with infection are not well understood.AimTo identify super-factors causing COVID-19 in staff China.MethodsA cross-sectional study was conducted between January 1st and February 30th, 2020, which front-line members who took part care treatment patients were enrolled. Epidemiological demographic data infected uninfected groups collected compared....
To investigate the CT imaging and clinical features of three atypical presentations coronavirus disease 2019 (COVID-19), namely (1) asymptomatic, (2) imaging-negative, (3) re-detectable positive (RP), during all stages.A consecutive cohort 79 COVID-19 patients was retrospectively recruited from five independent institutions. For each presentation type, were classified into vs. typical groups (i.e., asymptomatic vs.symptomatic, imaging-negative imaging-positive, RP non-RP,respectively). The...
Both coronavirus disease 2019 (COVID-19) and influenza pneumonia are highly contagious present with similar symptoms. We aimed to identify differences in CT imaging clinical features between COVID-19 the early stage most valuable differential diagnosis. Seventy-three patients confirmed by real-time reverse transcription-polymerase chain reaction (RT-PCR) 48 direct/indirect immunofluorescence antibody staining or RT-PCR were retrospectively reviewed. Clinical data including course of disease,...
Camellia species are ancient oilseed plants with a history of cultivation over two thousand years. Prior to oil extraction, natural seed drying is often practiced, process affecting fatty acid quality and quantity. MicroRNAs (miRNA) lipid metabolism associated camellia unexplored. To obtain insight into the function miRNAs in during drying, Illumina sequencing C. oleifera meiocarpa small-RNA was conducted.A total 274 candidate were identified 3733 target unigenes annotated by performing...
This study aimed to identify biomarkers for predicting the prognosis of advanced gastric cancer patients who received docetaxel, cisplatin, and S-1 (DCS).Gene expression profiles were obtained from Gene Expression Omnibus database (GSE31811). Gene-Ontology-enrichment KEGG-pathway analysis used evaluating biological functions differentially-expressed genes. Protein-protein interaction (PPI) network Kaplan-Meier survival analyses employed assess prognostic values hub genes.A total 1,486...
Phoebe bournei is a rare and endangered woody species the success of its plantation development dependent upon proper seedling cultivation. This study explored regulation N, P K fertilizer interaction these macronutrients on growth seedlings. To determine optimum rate ratio N–P–K in cultivation, we used unique “3414” incomplete orthogonal regression design to evaluate effects fertilization morphological development. One-year-old bareroot seedlings were grown for one growing season under...
Background: Rice seed proteins are lacking essential amino acids (EAAs). Genetic engineering offers a fast and sustainable method to solve this problem as it allows the specific expression of heterologous EAA-rich proteins. The use selectable marker gene is for generation transgenic crops, but might also lead potential environmental food safety problems. Therefore, production marker-free crops becoming an extremely attractive alternative could contribute public acceptance crops. Objectives:...
Radiation has been efficiently used for rice germplasm innovation. However, the molecular mechanisms by which radiation induces mutations are still unclear. In this study, we performed whole genome sequencing to reveal comprehensive in treated with radiation. Red-1 (a rich beneficial ingredients human health) was derived from 9311 after γ-radiation. Solexa technology applied uncover mutations. Compared genome, 9.19% of sequences were altered genome. Among these alterations, there 381 403...
Panax japonicus C. A. Mey. is a rare traditional Chinese herbal medicine that uses ginsenosides as its main active ingredient. Rice does not produce because it lacks key rate-limiting enzyme (β-amyrin synthase, βAS); however, produces secondary metabolite, 2,3-oxidosqualene, which precursor for ginsenoside biosynthesis.In the present study, P. βAS gene was transformed into rice cultivar 'Taijing 9' using an Agrobacterium-mediated approach, resulting in 68 transgenic plants of T0 generation....
Self-incompatibility (SI) is a mechanism used to prevent inbreeding and promote outcrossing in wide variety of angiosperms. Camellia oleifera (Theaceae), one the most prominent wood oil plants. However, self-incompatibility results relatively low ratio fruit/seed sets flowers C. oleifera. In this study, fluorescence microscopy confocal were observe how pollen tube growth differed between cross- vs. self-pollination events. We found that self-pollen tubes appear twisted clustered when growing...
To study the effect of N-P-K fertilization on Phoebe bournei seedlings’ organs dry biomass, and nutrients accumulation allocation, to further uncover how regulating biomass formation through fertilization, we utilized “3414” experiment design. The results showed that N, P, K fertilizer promoted accumulation, root, stem, total plant content in seedlings. accumulations increased first then decreased with increase application rates, which was basically consistent change allocations contents,...