A5018544690- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Eosinophilic Esophagitis
- Genetic factors in colorectal cancer
- Galectins and Cancer Biology
- Garlic and Onion Studies
- RNA modifications and cancer
- Inflammatory mediators and NSAID effects
- Epigenetics and DNA Methylation
- Veterinary medicine and infectious diseases
- Cancer, Lipids, and Metabolism
- Gastrointestinal disorders and treatments
- Gastroesophageal reflux and treatments
- Wnt/β-catenin signaling in development and cancer
- Gut microbiota and health
- Global Cancer Incidence and Screening
- Mycobacterium research and diagnosis
- Cancer Risks and Factors
- Nutrition, Genetics, and Disease
- Metabolomics and Mass Spectrometry Studies
- MicroRNA in disease regulation
- Estrogen and related hormone effects
- Ferroptosis and cancer prognosis
Peking University
2016-2025
Peking University Cancer Hospital
2016-2025
Fujian Medical University
2025
First Affiliated Hospital of Fujian Medical University
2025
Sichuan University
2024
Ministry of Education of the People's Republic of China
2024
Technical University of Munich
2019-2023
Ministry of Education
2009-2023
Beijing Municipal Health Bureau
2017
National Cancer Institute
1995-2014
In the Shandong Intervention Trial, 2 weeks of antibiotic treatment for Helicobacter pylori reduced prevalence precancerous gastric lesions, whereas 7.3 years oral supplementation with garlic extract and oil (garlic treatment) or vitamin C, E, selenium (vitamin did not. Here we report 14.7-year follow-up cancer incidence cause-specific mortality among 3365 randomly assigned subjects in this masked factorial placebo-controlled trial. Conditional logistic regression was used to estimate odds...
Background: Randomized trials have yielded mixed results on the effects of treatment for Helicobacter pylori and little information vitamins or garlic supplements precancerous gastric lesions. We conducted a randomized trial to test one-time H. long-term vitamin in reducing prevalence advanced Methods: Most adults aged 35–64 years 13 randomly selected villages Linqu County, Shandong Province, China, were identified given baseline endoscopies 1994. In 1995, 3365 eligible subjects assigned...
Interviews with 564 patients stomach cancer and 1,131 controls in an area of China where gastric rates are high revealed a significant reduction risk increasing consumption allium vegetables. Pearsons the highest quartile intake experienced only 40% those lowest. Protective effects were seen for garlic, onions, other allim foods. Although additional research is needed before etiologic inferences can be made, findings consistent recent reports tumor inhibition following administration...
Gastrointestinal microbiota may be involved in Helicobacter pylori-associated gastric cancer development. The aim of this study was to explore the possible microbial mechanisms carcinogenesis and potential dysbiosis arising from H. pylori infection.Deep sequencing 16S ribosomal RNA gene used investigate alterations paired biopsies stool samples 58 subjects with successful 57 failed anti-H. treatment, relative 49 negative subjects.In positive subjects, richness Shannon indexes increased...
To assess the effects of Helicobacter pylori treatment, vitamin supplementation, and garlic supplementation in prevention gastric cancer.Blinded randomized placebo controlled trial.Linqu County, Shandong province, China.3365 residents a high risk region for cancer. 2258 participants seropositive antibodies to H were randomly assigned or their placebos 2×2×2 factorial design, 1107 seronegative 2×2 design.H treatment with amoxicillin omeprazole two weeks; (C, E, selenium) (extract oil) 7.3...
Gastric cancer is generally thought to arise through a series of gastric mucosal changes, but the determinants precancerous lesions are not well understood. To identify such determinants, we launched follow-up study in 1989-1990 among 3433 adults Linqu County, China, region with very high rates cancer.Data on cigarette smoking, alcohol consumption, and other characteristics participants were obtained by interview 1989-1990, when an initial endoscopy was taken. At entry, antibodies...
Helicobacter pylori infection and the cytokine-mediated inflammatory responses play important roles in gastric cancer pathogenesis. This case control study was conducted to assess association between genetic polymorphisms interleukin (IL)-1B, IL-1RN, IL-8, IL-10 tumor necrosis factor alpha (TNFalpha), which are involved H.pylori infection, risk of cancer. Genotypes were determined by PCR-based denaturing high-performance liquid chromatography analysis direct DNA sequencing 250 incident cases...
Background To investigate the potential of serum miRNAs as biomarkers for early detection gastric cancer (GC), a population-based study was conducted in Linqu, high-risk area GC China. Methodology/Principal Findings All subjects were selected from two large cohort studies. Differential identified pools and control using TaqMan low density array, validated individual 82 pairs control, 46 dysplasia by real-time quantitative reverse transcription-polymerase chain reaction. The temporal trends...
Background: Stomach cancer is generally thought to evolve through a series of gastric mucosal changes, but the derterminants precancerous lesions are not well understood. purpose : Our was assess risk factors for intestinal metplasia and dysplasia arising from chronicatrophic gastritis in genral population at high stomach cancer. Methods A population-based gastroscopic screening more than 3000 residents conducted county china eith one world's highest rtes Information on lifestyle other...
<h3>Objective</h3> To clarify the full range of benefits and adverse consequences <i>Helicobacter pylori</i> eradication as a strategy for gastric cancer prevention, community-based intervention trial was launched in Linqu County, China. <h3>Design</h3> A total 184 786 residents aged 25–54 years were enrolled this received <sup>13</sup>C-urea breath test. <i>H. positive participants assigned into two groups, either receiving 10-day quadruple anti-<i>H. treatment or lookalike placebos...
Among 2258 Helicobacter pylori-seropositive subjects randomly assigned to receive one-time H. pylori treatment with amoxicillin-omeprazole or its placebo, we evaluated the 15-year effect of on gastric cancer incidence and mortality in subgroups defined by age, baseline histopathology, post-treatment infection status. We used conditional logistic Cox regressions for covariable adjustments analyses, respectively. Treatment was associated a statistically significant decrease (odds ratio = 0.36;...
<h3>Objective</h3> <i>Helicobacter pylori</i> infection and overexpression of cyclo-oxygenase-2 (COX-2) are associated with gastric cancer its precursors. To evaluate the effect a selective COX-2 inhibitor alone combined <i>H eradication on evolution precancerous lesions, randomised, placebo-controlled trial was conducted in Linqu County, Shandong Province, China. <h3>Methods</h3> A total 1024 participants aged 35–64 years advanced lesions were randomly assigned factorial design to two...
Eradication of Helicobacter pylori has been found to be effective for gastric cancer prevention, but uncertainties remain about the possible adverse consequences such as potential microbial dysbiosis. In our study, we investigated association between gut microbiota and H. pylori-related lesions in 47 subjects by deep sequencing 16S ribosomal RNA (rRNA) gene fecal samples. The dominant phyla samples were Bacteroidetes, Firmicutes Proteobacteria with average relative abundances 54.77%, 31.37%...
Gastric cancer (GC) is one of the major cancers in China and all over world. Most GCs are diagnosed at an advanced stage with unfavorable prognosis. Along some other countries, has developed government-funded national screening programs for GC cancers. been shown to effectively decrease incidence mortality from countries adopting nationwide (Japan Korea) studies based on selected Chinese populations. The relies mostly gastroendoscopy, accuracy, reliability safety which have indicated by...
<h3>Importance</h3> Metabolic deregulation plays an important role in gastric cancer (GC) development. To date, no studies have comprehensively explored the metabolomic profiles along cascade of lesions toward GC. <h3>Objective</h3> draw a metabolic landscape and define signatures associated with progression risk early <h3>Design, Setting, Participants</h3> A 2-stage, population-based cohort study was initiated 2017 Linqu County, Shandong Province, China, high-risk area for Prospective...
The pathogenesis of gastric cancer (GC), particularly the intestinal type, is thought to involve a multistep and multifactorial process. Our objective was determine rates transition from early advanced lesions in population Linqu County, China, where GC are among highest world. An endoscopic screening survey launched 1989–1990 3,399 residents aged 34–64 years with precancerous diagnosed biopsies taken 7 standard locations stomach any suspicious sites. cohort subsequently followed,...
ABSTRACT Background. Helicobacter pylori infection is a major cause of peptic ulcer disease and gastric cancer. This study postulated that cranberry juice would be effective in the suppression H. an endemically infected population at high risk for Materials methods. A prospective, randomized, double‐blind, placebo‐controlled trial was conducted Linqu County Shandong Province, China, where 189 adults aged 48.9 ± 11.2 years (mean SD) with were randomly divided into two groups: (n = 97) placebo...