A5101525584- Hearing, Cochlea, Tinnitus, Genetics
- Helicobacter pylori-related gastroenterology studies
- Vestibular and auditory disorders
- Gut microbiota and health
- Cancer-related molecular mechanisms research
- Hearing Loss and Rehabilitation
- Glaucoma and retinal disorders
- Catalytic C–H Functionalization Methods
- Computational Drug Discovery Methods
- Image and Signal Denoising Methods
- Hepatitis B Virus Studies
- Noise Effects and Management
- Advanced Image Processing Techniques
- Metabolomics and Mass Spectrometry Studies
- Gastric Cancer Management and Outcomes
- Antibiotic Use and Resistance
- Synthesis and Biological Evaluation
- Nonlinear Partial Differential Equations
- Natural product bioactivities and synthesis
- Antibiotic Resistance in Bacteria
- Ear Surgery and Otitis Media
- Advanced Mathematical Modeling in Engineering
- Fluorine in Organic Chemistry
- Mesenchymal stem cell research
- Urinary Tract Infections Management
Gannan Medical University
2017-2025
First Affiliated Hospital of Xi'an Jiaotong University
2020-2025
Yangzhou University
2023-2025
Beijing Tsinghua Chang Gung Hospital
2020-2024
Tsinghua University
2020-2024
South China Normal University
2024
Hebei Medical University
2024
Xingtai People's Hospital
2024
Harbin Institute of Technology
2021-2024
Peking University
2015-2023
Gastrointestinal microbiota may be involved in Helicobacter pylori-associated gastric cancer development. The aim of this study was to explore the possible microbial mechanisms carcinogenesis and potential dysbiosis arising from H. pylori infection.Deep sequencing 16S ribosomal RNA gene used investigate alterations paired biopsies stool samples 58 subjects with successful 57 failed anti-H. treatment, relative 49 negative subjects.In positive subjects, richness Shannon indexes increased...
Eradication of Helicobacter pylori has been found to be effective for gastric cancer prevention, but uncertainties remain about the possible adverse consequences such as potential microbial dysbiosis. In our study, we investigated association between gut microbiota and H. pylori-related lesions in 47 subjects by deep sequencing 16S ribosomal RNA (rRNA) gene fecal samples. The dominant phyla samples were Bacteroidetes, Firmicutes Proteobacteria with average relative abundances 54.77%, 31.37%...
San-Huang-Yi-Shen capsule (SHYS) has been used in the treatment of diabetic nephropathy (DN) clinic. However, mechanisms SHYS on DN remain unknown. In this study, we a high-fat diet (HFD) combined with streptozotocin (STZ) injection to establish rat model. Next, 16S rRNA sequencing and untargeted metabolomics study potential DN. Our results showed that alleviated body weight loss, hyperglycemia, proteinuria, pathological changes kidney rats. could also inhibite oxidative stress inflammatory...
We report the genetic analysis of autosomal dominant, nonsyndromic, progressive sensorineural hearing loss in a Chinese family. Using whole exome sequencing, we identified missense variant (c.130C>T, p.R44C) MCM2 gene, which has pro-apoptosis effect and is involved initiation eukaryotic genome replication. This very likely to be disease causing variant. It segregated with this pedigree, was not found dbSNP database or databases genomes SNP population, 76 patients sporadic loss, 145 normal...
Mandibular horizontally impacted teeth (MHIT) often require extraction due to complications such as pericoronitis, caries, and periodontal disease. This study explores the efficacy of "" shaped crown sectioning method for these extractions. From May 2021 2023, 240 patients undergoing MHIT were randomly double-blindly assigned group. (n = 120) using a micro-power system or control group an ultrasonic instrument. Key outcomes measured included operation time, alveolar damage, postoperative...
Metabolites and their interactions with microbiota may be involved in Helicobacter pylori-associated gastric lesion development. This study aimed to explore metabolite alterations upon H. pylori eradication possible roles of microbiota-metabolite progression precancerous lesions. Targeted metabolomics assays 16S rRNA gene sequencing were conducted investigate metabolic microbial paired biopsy specimens 58 subjects successful 57 failed anti-H. treatment. Integrative analyses performed by...
Diabetic retinopathy (DR) is a leading cause of vision loss, with early detection challenging due to asymptomatic progression and limited predictive tools. To address this, we aimed develop validate risk nomogram for DR prediction in type 2 diabetes patients. In this retrospective cohort study 70,073 patients admitted from 2013 2019, 2,585 were included after exclusions. Patients randomly assigned derivation (2/3) validation (1/3) sets. The model was derived using Cox proportional hazards...
Alternative mRNA splicing (AS) contributes greatly to expanding the diversity and function of proteome. Increasing evidence has suggested that dysregulation may be associated with various types cancer. In present study, RNA sequencing data were used investigate alterations global landscape cellular genes from 452 stomach adenocarcinoma (STAD) tissues available in The Cancer Genome Atlas. Seven AS events, including profiles exon skipping analyzed using SpliceSeq software. A total 60,754...
A growing body of research recently suggested the association between vestibular dysfunction and cognitive impairment. Meniere's disease (MD), a common clinical disorder, is usually accompanied by hearing loss emotional stress, both which may mediate relationship vestibule cognition. It currently unknown whether decline in MD patients could improve through treatment how it relates to multiple characteristics, particularly severity vertigo. Therefore, present study, were followed up for 3, 6,...
Cholesteatoma is a chronic disease that pathologically displays benign tumor with excessive squamous epithelial cell proliferation in the middle ear. Clinically, however, it can manifest malignant behavior by destroying adjacent tissues and organs. Although previous studies have demonstrated pathogenesis of cholesteatoma correlated epigenetic dysregulation, exact mechanism remains unclear. Circular RNAs (circRNAs) been revealed as being abundantly expressed various organisms found to...
Normal facial nerve (FN) function is very important for human being. However, if injured, FN difficult to restore completely. Recently, many studies reported the immune regulation of stem cells (SCs). immunomodulation SCs on injury still unclear. Our study aims explore mechanism effect Sprague–Dawley rat bone marrow-derived (BMSCs) and specially focus Th17 protection effects BMSCs central motor neurons (FMNs). First, FNs were harvested. cultured together or separately levels transforming...
Methylated Septin9 (mSEPT9) has been suggested for CRC detection. To assess the performance of mSEPT9 in Western China, we compared its diagnostic and recurrence monitoring values with fecal occult blood test (FOBT), carcinoembryonic antigen (CEA) carbohydrate 19-9 (CA 19-9).Overall 300 subjects including 209 patients 91 healthy subjects, who have performed mSEPT9, FOBT, CEA CA19-9 tests, were involved. Sensitivity, specificity, area under ROC curve (AUC) used to evaluate efficacy each...
Abstract In this paper, a fractional‐order nonlinear reaction diffusion system is proposed to remove the multiplicative Gamma noise. The new consists of three equations: regularized Perona and Malik (PM) equation , which used for presmoothing image that contaminated by noise; time‐delay regularization equation, incorporating past information into process adjusting oversmoothing; removing noise maintaining texture. coupled, leading difficulty in theoretical analysis. To end, we use decoupled...
Recognition of auditory brainstem response (ABR) waveforms may be challenging, particularly for older individuals or those with hearing loss. This study aimed to investigate deep learning frameworks improve the automatic recognition ABR in participants varying ages and levels.
Aim: Psoriasis is an immune-mediated skin disease that occurs worldwide and characterized by high prevalence chronicity. has a complex pathogenesis difficult to cure. Therefore, continuous exploration of the psoriasis search for new drug treatment methods are crucial improving efficiency reducing psychological damage patients. The active ingredients in Dihuang Zicao granules (DHZCG) can effectively treat psoriasis. this study aimed analyze DHZCG their potential mechanisms treating Methods:...
Oxazoles are important five-membered heterocycles that contain both nitrogen and oxygen atoms. Due to their wide range of biological activities, many oxazoles demonstrate potential for extensive application in various fields, including medicinal chemistry. Trifluoromethyl carbinol, an pharmacophore, contains trifluoromethyl hydroxyl groups is common molecules with activities. Constructing a carbinol unit undoubtedly valuable expanding the chemical space drug discovery. In this study, simple...