A5041184873- Hearing, Cochlea, Tinnitus, Genetics
- Vestibular and auditory disorders
- Ear Surgery and Otitis Media
- Hearing Loss and Rehabilitation
- Facial Nerve Paralysis Treatment and Research
- Ear and Head Tumors
- Glaucoma and retinal disorders
- Ophthalmology and Eye Disorders
- Head and Neck Surgical Oncology
- Reproductive Biology and Fertility
- Olfactory and Sensory Function Studies
- Congenital Ear and Nasal Anomalies
- Neurobiology and Insect Physiology Research
- Noise Effects and Management
- Meningioma and schwannoma management
- Congenital heart defects research
- Biochemical Analysis and Sensing Techniques
- Animal Genetics and Reproduction
- Cerebral Venous Sinus Thrombosis
- Xenotransplantation and immune response
- melanin and skin pigmentation
- Blood Coagulation and Thrombosis Mechanisms
- Long-Term Effects of COVID-19
- Head and Neck Anomalies
- Trigeminal Neuralgia and Treatments
Beijing Tsinghua Chang Gung Hospital
2016-2024
Tsinghua University
2016-2024
Statistical Research (United States)
2024
Patients First
2024
Chinese PLA General Hospital
2011-2016
The Military General Hospital of Beijing PLA
2016
Beijing Tian Tan Hospital
2008-2015
Capital Medical University
2014-2015
Conclusion: In patients with undeveloped vestibular/oval windows and inaccessible round windows, Vibrant Soundbridge (VSB) implantation performed by placing the transducer into a reconstructed window on inner tympanum wall demonstrated significant improvement in hearing verbal communication ability. Objective: To report our surgical experience new placement of VSB pediatric vestibular severe bilateral congenital aural atresia (CAA). Methods: two CAA selected for middle ear implantation, CT...
Genesis of novel gene regulatory modules is largely responsible for morphological and functional evolution. De novo generation cis-regulatory elements (CREs) much rarer than genomic events that alter existing CREs such as transposition, promoter switching or co-option. Only one case de has been reported to date, in fish without involvement phenotype alteration. Yet, this event likely occurs other animals helps drive genetic/phenotypic variation. Using a porcine model spontaneous hearing loss...
To report the cochlear morphology and electrophysiology of Chinese experimental miniature pigs. Twenty pigs were used in this study. Auditory brainstem responses (ABR), endolymphatic potentials (EP), potassium concentrations endolymph recorded. Hair cell was examined using electron microscopy. The capsule cochlea pig has three one-half turns which contains a 39-mm long membranous labyrinth. organ Corti labyrinth encompasses rows outer hair cells one row inner cells. stereocilia apical turn...
Gene therapy is a promising clinical solution to hearing loss. However suitable gene carriers for the auditory system are currently unavailable. Given unique structure of inner ear, route delivery and transfer efficiency still not optimal at present. This study presented non-viral in vivo Atoh1 (a potentially therapeutic loss) rat cochlea. We treated polyamidoamine (PAMAM) dendrimers by activating modifying with Na-carboxymethyl-beta-cyclodextrins (CM-beta-CD) sequence. A novel carrier...
A growing body of research recently suggested the association between vestibular dysfunction and cognitive impairment. Meniere's disease (MD), a common clinical disorder, is usually accompanied by hearing loss emotional stress, both which may mediate relationship vestibule cognition. It currently unknown whether decline in MD patients could improve through treatment how it relates to multiple characteristics, particularly severity vertigo. Therefore, present study, were followed up for 3, 6,...
Conclusion: Compared with traditional animal models, the miniature pig may be a better model for biomedical research because its morphology has many similarities that of humans. Objective: To investigate suitability as an otological regards morphology. Methods: Microdissection temporal bone 10 pigs was performed and recorded on photographs. Results: The measurements external, middle, inner ear, lateral recess were completed by microdissection. structures, including recess, similar in
The purpose of this study was to examine the morphological and functional development lateral wall scala media cochlea in miniature pigs; light transmission electron microscopy electrophysiology were used for purpose. We showed that appears at embryonic Day 21 (E21) when cochlear duct begins form. From E28 E49, can be distinguished according its position along cochlea. At E56, cells begin differentiate into three different types. E70, cell types, marginal, intermediate basal, clearly...
Ototoxic drugs can be used to produce a loss of cochlear hair cells create animal models deafness. However, the best our knowledge, there is no report on establishment rat deafness model through combined application aminoglycosides and loop diuretics. The aim this study was use single or administration furosemide kanamycin sulfate establish rats received intravenous injections different doses and/or intramuscular sulfate. auditory brainstem response measured determine hearing threshold after...
A variety of causes may induce sudden deafness. However, it remains challenging to determine the exact cause in a clinic. There is no standard treatment for this disease due its unclear etiology.The present study aims investigate clinical efficacy intratympanic injection dexamethasone treating deafness.A total 154 patients with deafness were retrospectively analyzed. The evaluation was based on AAO-HNS evaluative criteria. All initially treated within seven days by an intravenous drip...
Objective The purpose of this study was to investigate the incidence rate and audiological characteristics sudden sensorineural hearing loss (SSHL) before COVID-19 pandemic, during after inactivated vaccination, analyze whether novel coronavirus or vaccination have an impact on loss. Materials Methods clinical data all patients who visited hospital in July 2019 (before pandemic), 2020 (during pandemic) 2021 (after at least first basic dose vaccination) were retrospective analyzed. All...
In this investigation, a large mammal, Rongchang pigs were used to successfully establish research platform for cochlear implant study on the routine use of it in clinic.The aim was standard method mammal-pig.Rongchang selected, then divided into two groups: normal-hearing group (Mitf +/+) and mutation with hearing loss -/-). Cochlear implants ABR EABR recorded. The implanted electrodes observed by X-ray HE stains.The success best electrode position could be defined all animals, coiling...
Recognition of auditory brainstem response (ABR) waveforms may be challenging, particularly for older individuals or those with hearing loss. This study aimed to investigate deep learning frameworks improve the automatic recognition ABR in participants varying ages and levels.
Conclusions: We consider that the transmastoid-epitympanum approach to decompression of geniculate ganglion, without a craniotomy, combining advantages middle cranial fossa and transmastoid extralabyrinthine approaches, is simple, minimally invasive, safe, effective, with little postoperative hearing change. It can be employed in some cases facial palsy due temporal bone fracture (TBF) ear cholesteatoma (MEC) accordance range paralysis, nerve electrophysiology, imaging guidance. Objective:...
To investigate the suitability of miniature pigs as an animal model for otological research. Microdissection temporal bone was performed on 10 and recorded photographs. The morphology measurement external, middle inner ear lateral recess were obtained by microdissection. Compared to traditional models, pig may be a better biomedical research because its many similarities in physiological functions with humans. Similarities structures, including recess, between human make potentially useful
Objective: To investigate the surgical treatment and related experience of lateral skull base lesions.Methods: In a retrospective, clinical data analysis 20 patients with diseases, 11 cases temporal bone space-occupying lesions intracranial invasion were treated by translabyrinthine surgery, mastoid cavity drainage, or transmastoid surgery to remove lesion; two cholesteatoma destruction tympanic sinus canopy extended radical mastoidectomy; seven cerebrospinal fluid otorrhea caused trauma...
Background: Endolymphatic sac decompression surgery (ESDS) is commonly used for intractable Meniere’s disease, but its effect remains controversial because of the low rate vertigo control.Objectives: In present study, we examined ESDS combined with posterior tympanotomy local steroids as a new therapeutic strategy disease.Materials and methods: This retrospective study enrolled 19 patients disease using between 2015 2018. Postoperatively recorded evaluated changes in attack frequency hearing...
This study aimed to analyze the abnormal rates of immune related factors in serum sudden deafness (SD) patients, and discuss correlation between these indicators degree pathological changes SD patients.From March 2018 January 2021, 90 patients with who were hospitalized Beijing Tsinghua Changgeng Hospital enrolled as participants, 60 healthy examinees served control group. Antinuclear antibody (ANA), anticardiolipin immunoglobulin G (ACA-IgG), M (ACA-IgM), anti-β-glucoprotein (anti-β-GP)...
This study aimed to report 9 venous thromboembolism (VTE) cases after extracranial otologic surgery and analyze the potential risk factors. Case series. Single tertiary-level academic center. Totally, of VTE were identified among adults who underwent at our hospital from January 2018 December 2020. Caprini scores calculated, comprehensive preoperative, operative, postoperative clinical data within 14 days collected assess evidence VTE. The median age patients was 64 years old. Among them, 7...