A5101755183- Uterine Myomas and Treatments
- Ideological and Political Education
- Ear Surgery and Otitis Media
- Higher Education and Teaching Methods
- Education and Work Dynamics
- Urinary and Genital Oncology Studies
- Anesthesia and Sedative Agents
- Hearing, Cochlea, Tinnitus, Genetics
- Educational Technology and Pedagogy
- Anorectal Disease Treatments and Outcomes
- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- Endometriosis Research and Treatment
- Sport and Mega-Event Impacts
- Vestibular and auditory disorders
- Evaluation and Optimization Models
- Pelvic floor disorders treatments
- Anatomy and Medical Technology
- Surgical Simulation and Training
- Innovative Educational Techniques
- Winter Sports Injuries and Performance
- Reproductive System and Pregnancy
- Cardiovascular Health and Risk Factors
- Educational Reforms and Innovations
- Ear and Head Tumors
Anhui Medical University
2025
Peking Union Medical College Hospital
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Shanghai Changzheng Hospital
2025
University of Shanghai for Science and Technology
2021-2024
Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)
2024
Sun Yat-sen University
2024
Jiangnan University
2024
Nanchang University
2024
Yantaishan Hospital
2023
Centromeres are chromosomal structures required for equal DNA segregation to daughter cells, comprising specialized nucleosomes containing centromere protein A (CENP-A) histone, which provide the basis centromeric chromatin assembly. Discovery of components is progressing, but knowledge related their establishment and maintenance remains limited. Previously, using anti-CENP-A native immunoprecipitation, we isolated interphase–centromere complex (ICEN). Among ICEN components, subunits...
CENP-A is a component of centromeric chromatin and defines active centromere regions by forming centromere-specific nucleosomes. We have isolated containing the nucleosome, CENP-B, CENP-C from HeLa cells using anti-CENP-A and/or anti-CENP-C antibodies shown that CENP-A/B/C complex predominantly formed on α-satellite DNA contains CENP-B box (αI-type array). Mapping hypersensitive sites for micrococcal nuclease (MNase) digestion indicated nucleosomes were phased αI-type array as result...
Aims Propofol may result in hypotension, bradycardia and loss of protective reflexes, especially elderly patients, while esketamine, a N‐methyl‐D‐aspartate receptor antagonist, has analgesic, anaesthetic sympathomimetic properties is known to cause less cardiorespiratory depression. We hypothesized that esketamine reduce the median effective concentration (EC 50 ) propofol coadministration likely produce hypotension during gastrointestinal endoscopy patients. Methods Ninety aged 65–89 years,...
Abstract Background. The objective was to identify the risk factors for, and incidence of, facial palsy following conservative parotidectomy. Methods. Conservative parotidectomies for benign diseases ( N = 626) were studied retrospectively. postoperative determined by univariate multivariate analyses of variables related patient demographics, comorbid illnesses, characteristics operation. Results. rate transient palsies 23.16% Significant diabetic mellitus (odds ratio [OR] 1.727 [95% CI:...
Abstract Background Pulmonary benign metastasizing leiomyoma (PBML) is a rare disease characterized by of histopathology existing in the lungs. Because its rarity, limited literature with single case or small number cases has been regarding to clinical course, pathology management PBML. Methods A retrospective study was performed all PBML diagnosed and managed at Peking Union Medical College Hospital (PUMCH) from 2001 2019. The characteristics, pathology, treatment outcomes each were...
Abstract The ovary is crucial for female reproduction and health, as it generates oocytes secretes sex hormones. Transplantation of mesenchymal stem cells (MSCs) has been shown to alleviate pathological ovarian aging. However, unclear whether MSCs could benefit the naturally aging ovary. In this study, we first examined dynamics reserve Chinese women during perimenopause. Using a cynomolgus monkey ( Macaca fascicularis ) model, found that transplanting human embryonic cells-derived MSC-like...
To investigate the effect of icariin (ICA) on hepatocellular carcinoma (HCC) and its autophagy/apoptosis mechanism in HCC. The anti-HCC ICA was investigated using HCC cells treated with 20 µmol/L ICA. Cell viability proliferation were assessed CCK-8 colony formation assays, respectively, while TUNEL staining evaluated anti-apoptotic effects. DHE quantified intracellular ROS levels, JC-1 mitochondrial membrane potential. expression LC3 detected by immunofluorescence staining. Additionally,...
ABSTRACT Introduction Primary sensory processing is atypical in patients with autism spectrum disorder (ASD) and affects daily functioning. However, the functional connectivity (FC) patterns of primary networks ASD have not been systematically investigated. Methods were defined as four regions interest (ROIs) each brain hemisphere. We analyzed ROI‐wise FC 105 individuals 132 typically developing (TD) participants from Autism Brain Imaging Data Exchange I. calculated correlation between...
This study aimed to investigate the influence of cancer type on radiotherapy-induced otitis media with effusion (RTOME) occurrence and assess impact anatomical region-specific radiation exposure both RTOME incidence rates associated pathogenic processes. A retrospective analysis was conducted 1046 head neck (HNC) patients who underwent radiotherapy at Peking Union Medical College Hospital between 2016 2023. The assessed across various types, probabilities different regions were compared...
Three-dimensional (3D) visualization technology has been increasingly applied in patient-specific surgeries, but its value residency training not determined. This study aimed to explore the of 3D visualized pancreatic model tumor evaluation and surgery planning for surgical trainees. Eighty-eight residents were randomized into two groups (computed tomography (CT) group group). Both began with a on evaluating resectability tumor, which was based NCCN clinical practice guidelines practiced...
Pulmonary benign metastasizing leiomyoma (PBML) is the most common extrauterine spread of uterine leiomyoma, and its biological behavior traditionally thought to be hormone dependent. Studies on older PBML patients have been previously reported, but limited literature has published regarding clinical features treatment in young women.A total 65 cases women aged 45 years younger were reviewed, including 56 selected from PubMed 9 our hospital. The characteristics management these analyzed.The...
Background Currently, all the diagnostic indicators for endometriosis lack perfect sensitivity and specificity. According to characteristic of endometriosis, we analyzed new biomarker neutrophil-to-lymphocyte ratio (NLR) combination NLR serum CA-125 investigate their value identifying stages III IV endometriosis. Methods The values routine blood tests were collected from 197 patients with 102 benign tumors 112 healthy individuals. We investigated specificity its serum-CA-125 diagnosing by...
Background Remimazolam is a new ultra-short-acting benzodiazepine for procedural sedation and general anaesthesia, characterised by rapid onset of action, quick recovery, organ-independent metabolism. Older patients tend to sustain more treatment-emergent adverse events (TEAEs) worse perioperative prognoses after receiving remimazolam. However, few studies have investigated the appropriate dose remimazolam loss consciousness (LOC) in geriatric patients. We designed this study provide...
Accurate and rapid diagnosis is crucial for the effective treatment of parasitosis. Traditional etiological methods, especially microscopic examination, are time-consuming, labor-intensive, prone to false or missed detections. In response these challenges, this study explores use artificial intelligence (AI) detection classification human parasite eggs through YOLOv4 deep learning object algorithm.
The bone-anchored hearing device (BAHD) was not introduced in China until 2010. To our knowledge, this is the first study to assess efficacy of Chinese Mandarin-speaking patients with bilateral aural atresia.To evaluate speech recognition BAHDs as well patients' satisfaction using 2 questionnaires.A retrospective case review 16 atresia conducted at a tertiary referral center.A BAHD implanted during auricle reconstruction surgery or after rebuilt. A surgical method combine implantation second...
Abstract Background Current surgical therapies for pelvic organ prolapse (POP) do not repair weak vaginal tissue and just provide support; these may trigger severe complications. Stem cell-based regenerative therapy, due to its ability reconstruct damaged tissue, be a promising therapeutic strategy POP. The objective of this study is evaluate whether mesenchymal stem cell (MSC) therapy can in an ovariectomized rhesus macaque model. Methods A bilateral ovariectomy model was established...