A5100320339- Alzheimer's disease research and treatments
- Cholinesterase and Neurodegenerative Diseases
- Spondyloarthritis Studies and Treatments
- Esophageal and GI Pathology
- Gastric Cancer Management and Outcomes
- Cardiomyopathy and Myosin Studies
- Computational Drug Discovery Methods
- Neuroscience of respiration and sleep
- Stroke Rehabilitation and Recovery
- Osteoarthritis Treatment and Mechanisms
- Cardiovascular Effects of Exercise
- Gastrointestinal disorders and treatments
- Traditional Chinese Medicine Studies
- Asthma and respiratory diseases
- Nutrition and Health in Aging
- Biochemical effects in animals
- Rheumatoid Arthritis Research and Therapies
- Cardiovascular Function and Risk Factors
- Parkinson's Disease Mechanisms and Treatments
- Pancreatic and Hepatic Oncology Research
- Gastrointestinal Tumor Research and Treatment
- Neuroscience and Neuropharmacology Research
- Phytoestrogen effects and research
- Botulinum Toxin and Related Neurological Disorders
- Ophthalmology and Visual Impairment Studies
First Affiliated Hospital of Xiamen University
2013-2025
Xiamen University
2023-2025
China Medical University
2015-2025
Qilu Hospital of Shandong University
2012-2025
First Hospital of China Medical University
2015-2024
University of Kansas Medical Center
2001-2024
Donghua University
2024
University of Iowa
2019-2024
Xuzhou Medical College
2011-2024
University of Shanghai for Science and Technology
2021-2024
Metastatic disease is the major cause of cancer deaths, and recurrent tumors at distant organs are a critical issue. However, how metastatic tumor cells become dormant why recur in target not well understood. In this study, we demonstrate that BMP7 (bone morphogenetic protein 7) secreted from bone stromal induces senescence prostate stem-like (CSCs) by activating p38 mitogen-activated kinase increasing expression cell cycle inhibitor, p21, metastasis suppressor gene, NDRG1 (N-myc...
Compelling genetic evidence links the amyloid precursor protein (APP) to Alzheimer's disease (AD) and several theories have been advanced explain relationship. A leading hypothesis proposes that a small amphipathic fragment of APP, β-protein (Aβ), self-associates form soluble aggregates impair synaptic network activity. Here, we used most disease-relevant Aβ, isolated from AD brain. Using this material, show synaptotoxic effects Aβ depend on expression APP Aβ-mediated impairment plasticity...
The primary structure of canonical amyloid-β-protein was elucidated more than 30 years ago, yet the forms amyloid-β that play a role in Alzheimer's disease pathogenesis remain poorly defined. Studies brain extracts suggest amyloid-β, which migrates on sodium dodecyl sulphate polyacrylamide gel electrophoresis with molecular weight ∼7 kDa (7kDa-Aβ), is particularly toxic; however, nature this species has been controversial. Using sophisticated mass spectrometry and sensitive assays...
Abstract Purpose: To evaluate the effectiveness of progressive addition lenses (PALs), with a near +1.50 D, on progression myopia in Chinese children. Methods: We enrolled 178 juvenile‐onset acquired myopes (aged 7–13 years, −0.50 to −3.00 D spherical refractive error), who did not have moderately or highly myopic parents, for 2‐year prospective study. They were randomly assigned PAL group single vision (SV) group. Primary measurements, which included and ocular biometry, performed every 6...
Abstract Introduction Much knowledge about amyloid β (Aβ) aggregation and toxicity has been acquired using synthetic peptides mouse models, whereas less is known soluble Aβ in human brain. Methods We analyzed aqueous extracts from multiple AD brains an array of techniques. Results Brains can contain at least four different assembly forms including: (i) monomers, (ii) a ∼7kDa species, larger species (iii) ∼30‐150 kDa, (iv) >160 kDa. High molecular weight are by far the most prevalent...
Abstract Although the amyloid β-protein (Aβ) is believed to play an initiating role in Alzheimer’s disease (AD), molecular characteristics of key pathogenic Aβ forms are not well understood. As a result, it has proved difficult identify optimal agents that target disease-relevant Aβ. Here, we combined use Aβ-rich aqueous extracts brain samples from AD patients as source human and live-cell imaging iPSC-derived neurons develop bioassay capable quantifying relative protective effects multiple...
To identify factors that impact the procedure and treatment outcomes for endoscopic full-thickness resection (EFTR) of gastric submucosal tumors (SMTs).Medical records were collected all patients with SMTs who underwent EFTR procedures in Shengjing Hospital between June 2012 April 2014. The data from each patient reviewed, including gender, age, maximum tumor size on ultrasound (EUS), location stomach, length procedure, pneumoperitoneum during EFTR, cost to close defects, hospital stay after...
Accumulating evidence suggested that soluble oligomeric β-amyloid protein (Aβ) exerts diverse roles in neuronal cell death, neuroinflammation, oxidative stress, and the eventual dementia associated with Alzheimer's disease (AD). Developing an agent multiple properties may be a reasonable strategy for treatment of AD. In this study, we isolated novel multifunctional compound named camellikaempferoside B (YCF-2) from Fuzhuan brick tea. YCF-2 consists kaempferol backbone, p-coumaric acid (p-CA)...
Abstract Background The objective of this study was to determine the independent and incremental values advanced oxidative protein product (AOPP), interleukin 6 (IL-6), growth differentiation factor 15 (GDF15) in identifying arteriosclerosis patients with obstructive sleep apnea (OSA). Methods A total 104 individuals diagnosed OSA by polysomnography were recruited our study. Arteriosclerosis defined measuring ultrafast pulse wave velocity carotid artery. Peripheral venous blood samples...
Abstract Background Abundant experimental data have implicated an important role for insulin-like growth factor (IGF) in protecting neuronal cells from injury, including hypoxia/ischemia (H/I) a major cause of neuron death. While the specific interaction IGFs with or glial type 1 IGF receptors (IGF1R) has been shown to be essential actions during development, same not directly demonstrated following H/I injury. To examine IGF1R we utilized conditional mutant nes- igf1r -/Wt mice and...
Seven extraction methods, including hot water (HWE), pressurized (PWE), ultrasound-assisted extraction, microwave-assisted enzymatic high-speed shearing homogenization and ultrasound-microwave-assisted were utilized to extract polyphenolic-protein-polysaccharide complexes (PPPs) from Hovenia dulcis. Next, their physicochemical properties in vitro antioxidant activities, antiglycation effects, inhibition activities on α-glucosidase α-amylase studied compared. The findings this study indicate...
ABSTRACT Background Novel thrombotic molecular markers are significantly linked to acute ischemic stroke (AIS). However, the relationship between thrombin‐antithrombin complex (TAT), tissue plasminogen activator–inhibitor (t‐PAIC), plasmin‐α2 plasmin inhibitor (PIC), thrombomodulin (TM), and early neurological deterioration (END) remains unclear. Therefore, we developed a prediction model for END based on these evaluated its accuracy clinical utility. Methods Retrospective analysis of...