A5107341053- Alzheimer's disease research and treatments
- Adipose Tissue and Metabolism
- Autophagy in Disease and Therapy
- Cytokine Signaling Pathways and Interactions
- Pharmacological Effects of Natural Compounds
- Antifungal resistance and susceptibility
- Pain Mechanisms and Treatments
- Healthcare and Venom Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Orthopedic Surgery and Rehabilitation
- Inflammatory mediators and NSAID effects
- Salivary Gland Disorders and Functions
- Atrial Fibrillation Management and Outcomes
- Tendon Structure and Treatment
- Diet and metabolism studies
- Peptidase Inhibition and Analysis
- Neuroscience of respiration and sleep
- Obstructive Sleep Apnea Research
- Acute Myeloid Leukemia Research
- Cardiovascular Health and Risk Factors
- Radiomics and Machine Learning in Medical Imaging
- Neurofibromatosis and Schwannoma Cases
- Pediatric health and respiratory diseases
- Tryptophan and brain disorders
- Bacterial Identification and Susceptibility Testing
Tianjin Medical University
2023-2025
Shanghai Jiao Tong University
2018-2024
Shanghai Ninth People's Hospital
2024
First Hospital of China Medical University
2011-2024
China Medical University
2011-2024
The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital)
2024
First Affiliated Hospital of Jinan University
2024
Van Andel Institute
2024
Soochow University
2024
Zhejiang University
2015-2023
The stress hyperglycemia ratio (SHR) was developed to mitigate the influence of long-term chronic glycemic factors on levels, which are associated with adverse clinical events, particularly cardiovascular events. However, studies examining SHR index and its prognostic significance in patients atrial fibrillation (AF) lacking. This study aims evaluate relationship between all-cause mortality critically ill AF upon Intensive Care Unit admission.
The Duffy antigen/receptor for chemokines (DARC) is a promiscuous chemokine receptor that binds to members of the CXC family possessing angiogenic properties. DARC expressed on erythrocytes and endothelial cells required Plasmodium vivax infection erythrocytes. Approximately 70% African-Americans lack erythrocyte expression as genetic mechanism protection against malaria infection. African-American men have 60% greater incidence prostate cancer 2-fold higher mortality rate than Caucasian...
Alzheimer’s disease (AD) causes progressive loss of memory and cognition, exacerbated by APOE4, the greatest genetic risk factor for AD. One proposed mechanism apolipoprotein E (apoE) effects on cognition is via NMDAR-dependent signaling. APOE genotype-specific this pathway were dissected using EFAD-transgenic (Tg) mice (5xFAD mice, that over-express human amyloid-beta (Aβ) 5 familial-AD (FAD) mutations, express apoE), 5xFAD/APOE-knockout (KO) mice. Previous data from EFAD-Tg demonstrate...
Clearance of damaged cells and debris is beneficial for the functional recovery after ischemic brain injury. However, specific phagocytic receptor that mediates microglial phagocytosis stroke unknown.To investigate whether P2Y6 receptor-mediated clearance stroke.The expression in microglia increased within 3 days transient middle cerebral artery occlusion. Inhibition by selective inhibitor MRS2578 enlarged atrophy edema volume stroke, subsequently aggravated neurological function as measured...
Loganin, a major bioactive iridoid glycoside derived from Cornus officinalis, exerts different beneficial biological properties. Recently, loganin has been reported to exhibit potential anti-inflammatory effects in the intestinal tissues, while detailed mechanisms remain elusive. This study aimed investigate whether could inhibit inflammatory response dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) and explore possible molecular involved this process. Results showed that oral...
Dl-3-N-butylphthalide (NBP), a small molecule drug used clinically in the acute phase of ischemic stroke, has been shown to improve functional recovery and promote angiogenesis collateral vessel circulation after experimental cerebral ischemia. However, underlying molecular mechanism is unknown.To explore potential induced by NBP ischemia.NBP treatment attenuated body weight loss, reduced brain infarct volume, improved neurobehavioral outcomes during focal ischemia compared control rats (P <...
Oxidative stress and inflammatory reaction play critical roles in acute myocardial infarction (AMI). Isoliquiritigenin (ISL), a flavonoid monomer extracted from licorice, has been found to have antioxidant anti-inflammatory effects cancer studies. Here, we tested the effect underlying mechanisms of ISL on ischemia-induced injury mouse AMI model.Adult C57BL/6 mice were pre-treated by intraperitoneal injection and/or specific nuclear factor E2-related 2 (Nrf2) inhibitor ML385 for 3 days,...
In aging individuals, age-related cognitive decline is the most common cause of memory impairment. Among remedies, ginsenoside Rg1, a major active component ginseng, often recommended for its antiaging effects. However, role in improving during normal remains unknown and molecular mechanism partially understood. This study employed scheme Rg1 supplementation female C57BL/6J mice, which started at age 12 months ended 24 months, to investigate effects on performance. We found that improved...
Oxidative stress plays an important role in the progression of Alzheimer's disease (AD) and other neurodegenerative conditions. Glutathione (GSH), major antioxidant central nervous system, is primarily synthesized released by astrocytes. We determined if β-amyloid (Aβ42), crucially involved disease, affected GSH release. Monomeric Aβ (mAβ) stimulated release from cultured cortical astrocytes more effectively than oligomeric (oAβ) or fibrillary (fAβ). increased expression transporter ABCC1...
Despite evidence of a relationship among obstructive sleep apnea (OSA), metabolic dysregulation, and diabetes, it is uncertain whether OSA treatment can improve parameters. We sought to determine effects long-term continuous positive airway pressure (CPAP) on glycemic control diabetes risk in patients with cardiovascular disease (CVD) OSA.Blood, medical history, personal data were collected substudy 888 participants the Sleep Apnea cardioVascular Endpoints (SAVE) trial which stable CVD...
Abstract Objective The study aimed to investigate the change of amyloid precursor protein (APP) processing and β (Aβ) metabolites in linking periodontitis Alzheimer's disease (AD). Background Aβ is one main pathological features AD, few studies have discussed changes its expression peripheral tissues or analyzed relationship between imbalance production clearance. Methods A murine model was established by oral infection with Porphyromonas gingivalis (P. gingivalis) . Micro‐computed...
Alzheimer's disease (AD) is characterized by early impairments in memory and progressive neurodegeneration. Disruption of synaptic plasticity processes that underlie learning contribute partly to this pathophysiology. Tripchlorolide (T4 ), an extract from a traditional Chinese herbal Tripterygium wilfordii Hook F, has been shown be neuroprotective animal models Parkinson's improve cognitive deficits senescence-accelerated mouse P8. In study, we investigated the effect T4 on decline five...
Chemokine, monocyte chemoattractant protein-1 (MCP-1), is a potential factor to cause cancer-induced bone pain (CIBP). NF-κB signaling very important in mediating the expression of chemokines and may have role CIBP. However, mechanism still unclear. This study investigates CIBP by regulating MCP-1/chemokine CC motif receptor-2 (CCR2) pathway.A rat model was established injecting Walker-256 cells into tibia medullary cavity. Nine days later, animals were intrathecally administrated with MCP-1...
The cell wall is a dynamic structure that important for the pathogenicity of Candida albicans. Mannan, which located in outermost layer wall, has been shown to contribute pathogenesis C. albicans, however, molecular mechanism by this occurs remains unclear. Here we identified novel α-1,6-mannosyltransferase encoded MNN10 We found Mnn10 required α-1,6-mannose backbone biosynthesis and polysaccharides organization. Deletion resulted significant attenuation albicans murine systemic candidiasis...
This study classifies lung adenocarcinoma (ADC) and squamous cell carcinoma (SCC) using subregion-based radiomics features extracted from positron emission tomography/computed tomography (PET/CT) images.In this study, the standard 18F-fluorodeoxyglucose (FDG) PET/CT images of 150 patients with ADC 100 SCC were retrospectively collected PET Center First Affiliated Hospital, College Medicine, Zhejiang University. First, 3D feature vector each tumor voxel (whose basis is value, CT local...
Abstract As a crucial biophysical property, red blood cell (RBC) deformability is pathologically altered in numerous disease states, and biochemical structural changes occur over time stored samples of otherwise normal RBCs. However, there still gap applying it further to point-of-care devices due the large external equipment (high-resolution microscope microfluidic pump), associated operational difficulties, professional analysis. Herein, we revolutionarily propose smart optofluidic system...
Acupuncture (Acu) has been clinically validated as an effective treatment for depression. However, the underlying mechanism of Acu treatment's antidepressant effect remains unclear. Methods: We investigate effects at LR3 point in mice subjected to chronic social defeat stress (CSDS). GCaMP6m-based fiber-optic photometry was employed ventral CA1 (vCA1) regions first time monitor Ca2+ transients vivo during behavioral testing. Electrophysiological recordings were used detect activity and...
Murine Aim2 and Ifi202 genes (encoding for the p202 proteins) are members of IFN-inducible Ifi200 gene family. The deficiency in mice activates IFN signaling stimulates expression lupus susceptibility gene, Ifi202, located within NZB autoimmunity 2 (Nba2) interval. Given that Fcgr2b inhibitory FcγRIIB receptor) is associated with increased mice, we investigated whether protein could regulate gene. In this article, report suppresses receptor. Interestingly, Fcgr2b-deficient cells expressed...