A5044966606- 3D Printing in Biomedical Research
- Biosensors and Analytical Detection
- RNA Interference and Gene Delivery
- Fire dynamics and safety research
- Microfluidic and Bio-sensing Technologies
- Plant Molecular Biology Research
- Microfluidic and Capillary Electrophoresis Applications
- Gout, Hyperuricemia, Uric Acid
- Immunotherapy and Immune Responses
- Evacuation and Crowd Dynamics
- Muscle activation and electromyography studies
- Immune cells in cancer
- Cell Image Analysis Techniques
- Case Reports on Hematomas
- Epigenetics and DNA Methylation
- AI in cancer detection
- Network Traffic and Congestion Control
- Cancer-related molecular mechanisms research
- Phagocytosis and Immune Regulation
- Pharmacological Effects of Natural Compounds
- Botanical Research and Applications
- Analytical Chemistry and Sensors
- Genomics and Phylogenetic Studies
- interferon and immune responses
- Wireless Body Area Networks
Wuhan University
2021-2025
Renmin Hospital of Wuhan University
2022-2025
Jilin University
2011-2025
Kunsan National University
2024-2025
City University of Hong Kong, Shenzhen Research Institute
2022-2025
Affiliated Hospital of Liaoning University of Traditional Chinese Medicine
2025
Liaoning University of Traditional Chinese Medicine
2025
Taiyuan University of Technology
2025
Zhongshan Hospital of Xiamen University
2025
China Medical University
2020-2024
Innate immune system is armed by several lines of pattern recognition receptors to sense various viral infection and initiate antiviral response. This process under a tight control the negative feedback induced and/or inflammation critical maintain homoeostasis prevent autoimmune disorders, however, molecular mechanism not fully understood. Here we report TRIM29, ubiquitin E3 ligase, functions as an inducible regulator innate response triggered DNA virus cytosolic DNA. stimulation induce...
Abstract Artificial intelligence (AI) holds immense promise for K-12 education, yet understanding the factors influencing students’ engagement with AI courses remains a challenge. This study addresses this gap by extending technology acceptance model (TAM) to incorporate cognitive such as intrinsic motivation (AIIM), readiness (AIRD), confidence (AICF), and anxiety (AIAX), alongside human–computer interaction (HCI) elements like user interface (UI), content (C), learner-interface...
BackgroundTumor cells benefit from tumor-associated macrophages (TAMs) promoting tumor growth and modulating functions of other in microenvironment (TME). However, how regulate the property TAMs during invasion remains to be defined.MethodsMouse models cancer patients' samples were analyzed determine LAMP2a expression TAMs. In vitro mouse primary used assess LAMP2a-modulated macrophage activation, verify LAMP2a's target proteins. The effect LAMP2a-knockdown on progression TME maintaining was...
Regionalized optical irradiation of “endothelialized” micro-channels induced thrombosis on a microfluidic toxicology platform demonstrating the realistic reproduction invasion microplastics.
Rapid construction of size-controllable 3D tumor spheroid arrays based on acoustic bubbles in microfluidic chips for situ drug response testing.
The development of intelligent blood coagulation diagnoses is awaited to meet the current need for large clinical time-sensitive caseloads due its efficient and automated diagnoses. Herein, a method reported validated realize it through artificial intelligence (AI)-assisted optical clotting biophysics (OCB) properties identification. image differential calculation used precise acquisition OCB with elimination initial differences, strategy space-time regulation allows on-demand space time...
Pentatricopeptide repeat (PPR) proteins form a large protein family and have diverse functions in plant development. Here, we identified an ALBINO EMBRYO AND SEEDLING (AES) gene that encodes P-type PPR expressed various tissues, especially the young leaves of Arabidopsis (Arabidopsis thaliana). Its null mutant aes exhibited collapsed chloroplast membrane system, reduced pigment content photosynthetic activity, decreased transcript levels PEP (plastid-encoded polymerase)-dependent genes,...
Abstract Overexpression of folate receptor alpha (FRα) and high telomerase activity are considered to be the characteristics ovarian cancers. In this study, we developed FRα-targeted lipoplexes loaded with an hTERT promoter-regulated plasmid that encodes a matrix protein (MP) vesicular stomatitis virus, F-LP/pMP (2.5) , for application in cancer treatment. We first characterized pharmaceutical properties . The efficient expression MP-driven promoter SKOV-3 cells was determined after in-vitro...
Interleukin-15 has been implicated as a promising cytokine for cancer immunotherapy, while folate receptor α (FRα) shown to be potentially useful target colon therapy. Herein, we developed F-PLP/pIL15, FRα-targeted lipoplex loading recombinant interleukin-15 plasmid (pIL15) and studied its antitumor effects in vivo using CT26 mouse model. Compared with control (normal saline) treatment, F-PLP/pIL15 significantly suppressed tumor growth regard weight (P < 0.001) reduced nodule formation...
Abstract As a crucial biophysical property, red blood cell (RBC) deformability is pathologically altered in numerous disease states, and biochemical structural changes occur over time stored samples of otherwise normal RBCs. However, there still gap applying it further to point-of-care devices due the large external equipment (high-resolution microscope microfluidic pump), associated operational difficulties, professional analysis. Herein, we revolutionarily propose smart optofluidic system...
This study focuses on predicting mechanical fatigue in excavator turntables, critical components susceptible to failure due variable operational loads. While conventional methods like finite element analysis(FEA) and multiaxial criteria have been used, they are limited by the complexity cost of obtaining real load spectra. To address this challenge, our research presents a comprehensive approach that integrates multi-body dynamics modeling, analysis, MATLAB-based life prediction systems. Our...
Alligator sinensis is an extremely rare species that possesses excellent camouflage, allowing it to fit perfectly into its natural environment. The use of camouflage makes detection difficult for both humans and automated systems, highlighting the importance modern technologies animal monitoring. To address this issue, we present YOLO v8-SIM, innovative technique specifically developed significantly enhance identification precision. v8-SIM utilizes a sophisticated dual-layer attention...
Malignant pleural effusion (PE) and ascites, common clinical manifestations in advanced cancer patients, are associated with a poor prognosis. However, the biological characteristics of malignant PE ascites not clarified. Here we report that can induce frequent epithelial-mesenchymal transition program endow tumor cells stem cell properties high efficiency, which promotes growth, chemoresistance, immune evasion. We determine this process is mainly dependent on VEGF, one initiator...
Abstract The adoptive transfer of the natural regulatory B cells and macrophages should be a useful treatment for inflammation autoimmune disease. However, it is usually difficult to isolate these from tissues expand them. Here, we investigated feasibility adoptively transferring peritoneal (PCs) as DSS-induced colitis. We found that cavity can provide an easily accessible site harvesting enough number PCs, namely, two-dose PCs mouse in one operation. Adoptive therapy healthy mice or those...
Rationale: Cationic nanocarriers present with well-known toxicities, including inflammatory toxicity, which limit their clinical application.How the cationic nanocarrier-induced response is negatively regulated unknown.Herein, we found that following a sublethal dose of nanocarriers, induced characterized by early neutrophil infiltration and spontaneous resolution within 1 week.Methods: C57BL/6 mice were intravenously injected dosage 1-100 mg/kg DOTAP liposomes as well other materials.Cell...
Abstract Pathological cardiac hypertrophy is an independent risk factor for heart failure and considered a target the treatment of failure. However, mechanisms underlying pathological remain largely unknown. We aimed to investigate role angiopoietin-like protein 8 (ANGPTL8) in hypertrophy. found that serum ANGPTL8 levels were significantly increased hypertensive patients with mice induced by Ang II or TAC. Furthermore, secretion from liver was during hypertrophic processes, which triggered...
Cellular mechanical property analysis reflecting the physiological and pathological states of cells plays a crucial role in assessing quality stored blood. However, its complex equipment needs, operation difficulty, clogging issues hinder automated rapid biomechanical testing. Here, we propose promising biosensor assisted by magnetically actuated hydrogel stamping to fulfill it. The flexible magnetic actuator triggers collective deformation multiple light-cured hydrogel, it allows for...