A5052662827- Advanced Chemical Physics Studies
- Atomic and Molecular Physics
- 3D Printing in Biomedical Research
- Mass Spectrometry Techniques and Applications
- Innovative Microfluidic and Catalytic Techniques Innovation
- Catalytic Processes in Materials Science
- Spectroscopy and Quantum Chemical Studies
- Advanced Frequency and Time Standards
- Cold Atom Physics and Bose-Einstein Condensates
- Cancer-related molecular mechanisms research
- Microfluidic and Capillary Electrophoresis Applications
- Pickering emulsions and particle stabilization
- Microfluidic and Bio-sensing Technologies
- Photochemistry and Electron Transfer Studies
- Atomic and Subatomic Physics Research
- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Micro and Nano Robotics
- Electron and X-Ray Spectroscopy Techniques
- Molecular Junctions and Nanostructures
- Ovarian function and disorders
- X-ray Spectroscopy and Fluorescence Analysis
- Reproductive System and Pregnancy
- Catalysis and Oxidation Reactions
- Biosensors and Analytical Detection
Tsinghua University
2005-2025
Kailuan General Hospital
2025
Wuhan University
2020-2024
Renmin Hospital of Wuhan University
2020-2024
National Center for Nanoscience and Technology
2019-2020
Center for NanoScience
2019-2020
China Institute of Atomic Energy
2020
Southern Medical University
2018-2020
Center for Excellence in Education
2019-2020
State Council of the People's Republic of China
2019
Multiplexed microRNA (miRNA) detection has proven valuable in disease diagnosis; yet, the development of advanced tools for their analysis remains a subject broad interest. Here, we propose novel single-particle method multiplexed miRNA using self-directed hydrogel microspheres, which feature supersegmented compartments loading analyte probes and an air-encapsulated region that grants microsphere unique preferred posture aqueous solutions. By exploiting microfluidic technology, can widely...
Abstract A microfluidic assembly method based on a chip and capillary device was developed to create multicompartmental particles. The design endows the particles with regulable internal structure. By adjusting microstructure of chip, diameter capillary, gap length between two components, flow rates, size number or ratio different regions within particle could be widely varied. As proof concept, we have produced some complicated that even contain 20 compartments. Furthermore, potential...
Multicellular aggregates in three-dimensional (3D) environments provide novel solid tumor models that can insight into <italic>in vivo</italic> drug resistance.
Regionalized optical irradiation of “endothelialized” micro-channels induced thrombosis on a microfluidic toxicology platform demonstrating the realistic reproduction invasion microplastics.
The spherically averaged electron density distribution of the highest occupied molecular orbital (HOMO) for amino acid glycine has been determined by multichannel momentum spectroscopy. Comparison measured HOMO with near-Hartree-Fock limit and functional theory (DFT) calculations Boltzmann-weighted sum eight predicted stable conformers indicates that correlation effects must be included in order to adequately reproduce experimental results glycine. best-fitting DFT calculation Becke-Perdew...
Background. Endometrial cancer greatly threatens the health of female. Emerging evidences have demonstrated that DNA methylation and immune infiltration are involved in occurrence development endometrial cancer. However, mechanism prognostic biomarkers still unclear. In this study, we assess via bioinformatic analysis. Methods. The latest RNA-Seq, data, clinical data related to were downloaded from UCSC Xena dataset. methylation-driven genes selected, then risk score was obtained using...
The differential scattering cross sections and the generalized oscillator strengths of 1${\mathrm{}}^{1}$S\ensuremath{\rightarrow}2${\mathrm{}}^{1}$S 1${\mathrm{}}^{1}$S\ensuremath{\rightarrow}2${\mathrm{}}^{1}$P transitions helium have been measured by angle-resolved electron-energy-loss spectroscopy with an incident electron energy 1500 eV within range 2\ifmmode^\circ\else\textdegree\fi{}--11.5\ifmmode^\circ\else\textdegree\fi{} angles. corrections for angular factors density effects also...
Unexpected and previously unexplained behaviour showing appreciable intensity at low momenta in published binary (e, 2e) cross sections for ionization from atomic orbitals including Xe 4d, Zn 3d Cd 4d is investigated. Similar effects have also been observed recently studies of metal hexacarbonyls the least tightly bound molecular which are dominated by character. The finite (i.e. non-nodal behaviour) not predicted plane-wave calculations targets, but can be accounted using distorted-wave...
Experimental momentum profiles (orbital images) corresponding to the electron density distribution in outer valence shell of gaseous glycine have been obtained by spectroscopy measurements conducted over binding energy range 6−27 eV at an impact 1200 + energy. The experimental data are compared with theoretical calculated using Hartree−Fock and Kohn−Sham functional theories. correspond a Boltzmann weighted sum five dominant conformers predicted be present temperature 165 °C. importance basis...
Three-dimensional (3D) hydrogel microspheres have aroused increasing attention as an in vitro cell culture model. Yet the preservation of cells' original biological properties has been overlooked during model construction. Here we present integrated microfluidic device to accomplish overall process including cell-laden microsphere generation, online extraction, and dynamic-culture. The method extends noninvasive nonsuppression capabilities droplet preparation system provides a constant...
We report on the development of a microwave frequency standard based laser-cooled 171Yb+ ion trap system. The electronics , lasers, and magnetic shields are integrated into single physical package. With over 105 ions stably trapped, system offers high signal-to-noise ratio Ramsey line-shape. In comparison with previous work, instability clock was further improved to 8.5×10-13/τ for averaging times between 10 1000 s. Essential systematic shifts uncertainties also estimated.
Developing advanced tools for multicomponent analysis is an open challenge in engineering and life science. Herein, multicompartmental hydrogel microspheres with multi-material compatibility structural scalability are developed as a tool at single-particle level. Microfluidic technology endows particles adjustable sizes super-segmented layouts that can be used to load various analyte probes. In order perform analysis, these structurally divided into identifier regions indicating reading...
An acoustic streaming based rapid single-cell drug screening microfluidic device is developed. It achieved by non-invasively changing cell membrane permeability to accelerate absorption in concentration gradient field.
Abstract Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disease in women, with clinical manifestations of anovulation hyperandrogenaemia. The treatment PCOS mainly focuses on improving symptoms, such as insulin sensitivity or menstrual disorder, through drug treatment. However, due to the pathogenesis diversity PCOS, there still lack effective clinics. Metabolic disorder key factor occurrence PCOS. Brown adipose tissue (BAT) special human body that can participate...
Considerable efforts have been made to develop microscale multiplexing strategies. However, challenges remain due the difficulty in deploying functional objects and decoding high-density signals on anisotropic microcarriers. Here, we report a microfluidic method fabricate architecture-marked particles for performing designable multiplexed assays label-free manner. By controlling fluid assembly rapid in-air cross-linking, are endowed with multiple regions unique architecture identifier. The...
Hypertension is the most prevalent chronic disease globally and treatment control ratio of hypertension patients are still low. The function lncRNA MIR210HG in has not yet been announced. Eighty-three 79 healthy individuals were enrolled. Human Umbilical Vein Endothelial Cells (HUVECs) treated with Ang II employed to imitate hypertension. relative expression miR-125b-5p evaluated by qRT-PCR while ROC curve was applied assess diagnostic performance MIR210HG. CCK-8 assay performed detect...
The metastatic cascade of cancer stem cells (CSCs) is always accompanied by elevated levels adenosine triphosphate (ATP) as well the alteration energy metabolism to support their differentiation and migration.
Cytotoxic T-lymphocyte associated protein 4 (CTLA4) inhibitors have been shown to significantly prolong the overall survival (OS) in a wide range of cancers. However, its application clear cell renal carcinoma (ccRCC) is limited due therapy response, and prognostic value CTLA4 ccRCC has not investigated detail. By using immunohistochemistry, Kaplan-Meier (K-M) analysis, uni- multi-variate Cox we comprehensively systematically studied ccRCC. Then, applied Gene Ontology (GO), Kyoto...