A5065928320- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Cancer, Hypoxia, and Metabolism
- Circular RNAs in diseases
- Aldose Reductase and Taurine
- Endometrial and Cervical Cancer Treatments
- Reproductive System and Pregnancy
Minda Hospital
2021-2025
Background. Endometrial cancer greatly threatens the health of female. Emerging evidences have demonstrated that DNA methylation and immune infiltration are involved in occurrence development endometrial cancer. However, mechanism prognostic biomarkers still unclear. In this study, we assess via bioinformatic analysis. Methods. The latest RNA-Seq, data, clinical data related to were downloaded from UCSC Xena dataset. methylation-driven genes selected, then risk score was obtained using...
Abstract Background Clinically, hormone replacement therapy (HRT) is the main treatment for primary ovarian insufficiency (POI). However, HRT may increase risk of both breast cancer and cardiovascular disease. Exosomes derived from human umbilical cord mesenchymal stem cell (hUC-MSC) have been gradually applied to a variety diseases through inflammation inhibition, immune regulation, tissue repair functions. application study hUC-MSC exosomes in POI remain limited. Methods Here, we first...
Hepatocellular carcinoma (HCC) is one of the main causes cancer-associated deaths globally, accounts for 90% primary liver cancers. However, further studies are needed to confirm metabolism-related gene signature related prognosis patients with HCC.Using "limma" R package and univariate Cox analysis, combined LASSO regression a was established. The relationship between overall survival (OS) HCC analyzed. RT-qPCR used evaluate expression genes in clinical samples. GSEA ssGSEA algorithms were...
Circular RNAs (circRNAs) are covalently closed RNA structures that play a pivotal role in the initiation and progression of cervical cancer (CC). However, it is unclear how these influence stem cell (CSC)-like properties CC. Here, we performed circRNA microarray analysis identified an intergenic circRNA, hsa_circ_0007905, was significantly upregulated patients with Moreover, hsa_circ_0007905 found to be highly expressed CSC-enriched subsets lines. Functionally, knocking down suppressed...