A5024636552- Head and Neck Cancer Studies
- Lung Cancer Research Studies
- Lung Cancer Treatments and Mutations
- Brain Metastases and Treatment
- Glioma Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Advanced Radiotherapy Techniques
- Meningioma and schwannoma management
- Viral-associated cancers and disorders
- Cancer Research and Treatments
- Inflammatory Biomarkers in Disease Prognosis
- Peptidase Inhibition and Analysis
- Management of metastatic bone disease
- Radiation Therapy and Dosimetry
- Cell death mechanisms and regulation
- CNS Lymphoma Diagnosis and Treatment
- Ocular Oncology and Treatments
- RNA Research and Splicing
- Click Chemistry and Applications
- Circular RNAs in diseases
- Photodynamic Therapy Research Studies
- Virus-based gene therapy research
- Neutropenia and Cancer Infections
Sichuan University
2015-2025
Wuhan City Chinese Medicine Hospital
2023-2024
State Key Laboratory of Biotherapy
2013-2020
Beijing Sanbo Brain Hospital
2019
Capital Medical University
2019
The Central Hospital of Shaoyang
2019
Xian Yang Central Hospital
2019
Peking University
2018
West China Hospital of Sichuan University
2016-2017
Institute of Molecular Biology and Biophysics
2016
To report long‐term results of a randomized controlled trial that compared cisplatin/fluorouracil/docetaxel (TPF) induction chemotherapy (IC) plus concurrent chemoradiotherapy (CCRT) with CCRT alone in locoregionally advanced nasopharyngeal carcinoma (NPC). Patients stage III–IVB (except T3–4 N0) NPC were randomly assigned to receive IC (n = 241) or 239). included three cycles docetaxel (60 mg/m 2 d1), cisplatin and fluorouracil (600 /d civ d1–5) every 3 weeks. from both groups received...
Malignant pleural effusion (PE) and ascites, common clinical manifestations in advanced cancer patients, are associated with a poor prognosis. However, the biological characteristics of malignant PE ascites not clarified. Here we report that can induce frequent epithelial-mesenchymal transition program endow tumor cells stem cell properties high efficiency, which promotes growth, chemoresistance, immune evasion. We determine this process is mainly dependent on VEGF, one initiator...
This study aims to compare two induction chemotherapy regimens, TPF and GP, for patients with locally advanced nasopharyngeal carcinoma (NPC).We analyzed newly diagnosed stage III-IVA NPC (excluding T3/T4N0, AJCC) between December 2010 May 2015 who were treated or GP (IC) followed concurrent chemoradiotherapy (CCRT) those CCRT alone. Treatment compliance, survival outcomes grade 3-4 side effects compared among these three groups.A total of 189 eligible this study, 87 (46.0%), 71 (37.6%) 31...
The present study aimed to explore the association between SUA and NAFLD in women with different menstrual statuses.A total of 6043 were selected from Jidong Kailuan communities for inclusion study. levels participants divided into quartiles. was determined by abdominal ultrasonography. Data laboratory tests clinical examination collected, basic information obtained standardized questionnaires. status stratified period, menopause transition postmenopause. Multivariate logistic regression...
Abstract Background and Objective High‐grade glioma (HGG) is known to be characterized by a high degree of malignancy worse prognosis. The classical treatment safe resection supplemented radiotherapy chemotherapy. Tumor treating fields (TTFields), an emerging physiotherapeutic modality that targets malignant solid tumors using medium‐frequency, low‐intensity, alternating electric interfere with cell division, have been used for the new diagnosis glioblastoma, however, their administration in...
Immune checkpoint inhibitors (ICIs) show optimal treatment effects on recurrent or metastatic nasopharyngeal carcinoma(R/M NPC). Nonetheless, whether sites impact ICIs efficacy remains unclear. We performed a secondary analysis of R/M NPC patients treated with KL-A167, programmed cell death-ligand 1(PD-L1) inhibitor, based multicenter, single-arm, phase II study from China between 2019 and 2021 years, which represents the first most comprehensive effectiveness PD-L1 inhibitor in who have...
Neutrophil-to-lymphocyte ratio (NLR) can be treated as a simple indicator of patients' immune status by representing the state systemic inflammatory response. Immunotherapy now is accepted second-line treatment for recurrent or metastatic nasopharyngeal carcinoma (R/M NPC). However, significance NLR in patients with R/M NPC undergoing PD-L1 (programmed cell death-ligand 1) inhibitors still uncertain. We analyzed relationship between baseline 153 efficacy and survival from multicenter,...
Objective To predict the incidence of immune-related Adverse Events (irAEs) in patients with recurrent or metastatic Nasopharyngeal Carcinoma (NPC) treated Programmed Death-Ligand 1 (PD-L1) inhibitors, this study developed and validated nomogram models incorporating demographic, clinical, biological variables. Methods Data from 153 NPC were analyzed, variables including age, sex, Body Mass Index (BMI), clinical stage, biomarkers. Predictive constructed using multivariable logistic...
Addition of gemcitabine and cisplatin (GP) or docetaxel plus fluorouracil (TPF) to concurrent chemoradiotherapy (CCRT) significantly improved survival in locoregionally advanced nasopharyngeal carcinoma (NPC). However, an economic evaluation these regimens remains unknown. The purpose this study is compare the cost-effectiveness GP versus TPF regimen treatment NPC China.A comprehensive Markov model was developed evaluate health outcomes for patients with NPC. Baseline clinical outcome were...
This case report describes a 16-year-old patient with refractory Hodgkin's lymphoma who developed bilateral anterior and intermediate uveitis as an adverse reaction to Brentuximab vedotin (BV). is rare of ocular potentially related BV, symptoms like blurred vision, decreased visual acuity, photophobia, redness. Potential mechanisms include BV targeting CD30+ T cells in the uveal tissue or immune response triggered by microtubule-disrupting agent MMAE within BV. highlights need for vigilant...
MicroRNAs (miRs), a class of small non-coding RNAs, have been demonstrated to be involved in the development and progression human malignancies, including cutaneous squamous cell carcinoma (CSCC). miR-186 serves suppressive role certain common types cancer; however, its exact function CSCC has not reported previously. In present study, expression was significantly increased tissues compared with adjacent non-tumour tissues. Overexpression promoted proliferation while inhibiting apoptosis....
Abstract Background To investigate the effect of local treatment metastases on overall survival (OS) patients with metastatic nasopharyngeal carcinoma (NPC). Methods One hundred and forty‐seven were included. The association between OS was examined propensity score matching (PSM) method. Results In entire cohort, median significantly longer in plus chemotherapy compared to those alone (71.7 vs. 16.2 months; p < 0.001). PSM similar benefit observed (55.6 17.6 = 0.011). remained regardless...
Chronic obstructive pulmonary disease (COPD) is a serious health burden worldwide with high mortality. LncRNA plasmacytoma variant translocation 1 (PVT1) has been illustrated to serve as biomarker for COPD progression. Nonetheless, its specific functions and mechanisms in are unclarified.
Nasopharyngeal carcinoma (NPC) is a common head and neck cancer with poor prognosis. There an urgent need to develop simple convenient screening tool for early detection risk of NPC. 139 microbial samples were collected from 40 healthy people 39 patients nasopharyngeal biopsy. A total oral, eight 27 nasal cavity, nine 16 the two sets individuals. NPC was established by 16S rDNA sequencing random forest. Patients biopsy had significantly lower cavity nasopharynx diversities than people. The...
The prognosis of metastatic breast cancer is always very poor. Thus, it urgent to develop novel drugs with less toxicity against cancer. A new drug (XC-591) derived from benzothiazole-2-thiol was designed and synthesized in our lab. In this study, we tried assess effects XC-591 treatment on primary pulmonary metastasis 4T1 mice model. Furthermore, discover its possible molecular mechanism action. MTT experiment showed had significant anti-cancer activity diverse cells. significantly...
Recent studies have suggested that the action of IkappaB kinase alpha (IKKα) as a tumor suppressor is crucial in development skin carcinoma, but its role nasopharyngeal carcinoma (NPC) remains unknown. We examined IKKα expression specimens from 157 NPC patients by immunohistochemistry and analyzed effect on prognosis. The functional significance cell lines was investigated overexpression or downregulation vitro studies. assays revealed negatively correlated with invasiveness, migration,...
To determine the M1 sub-staging in synchronous metastatic nasopharyngeal carcinoma (smNPC) and to examine effect of nasopharyngeal-neck radiotherapy (RT) local treatment metastases on overall survival (OS) smNPC patients.A total 150 patients with were included. Metastatic characteristics associated their potential prognostic significance analyzed. Then, a stratification system was provided according features. Moreover, OS or without RT compared by Log rank test. The who received did not...