A5103246414- Head and Neck Cancer Studies
- Lung Cancer Research Studies
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Lung Cancer Treatments and Mutations
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Advanced Radiotherapy Techniques
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Effects of Radiation Exposure
- DNA Repair Mechanisms
- Head and Neck Surgical Oncology
- Cancer-related Molecular Pathways
- Circular RNAs in diseases
- Neuroscience and Neuropharmacology Research
- Proteoglycans and glycosaminoglycans research
- Radiation Dose and Imaging
- Microbial metabolism and enzyme function
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Diagnosis and Treatment
- Fibroblast Growth Factor Research
- Management of metastatic bone disease
- Radiomics and Machine Learning in Medical Imaging
- Pain Mechanisms and Treatments
- Cell death mechanisms and regulation
Third Affiliated Hospital of Sun Yat-sen University
2018-2025
Sun Yat-sen University
2018-2025
Xuzhou Medical College
2020-2025
Sun Yat-sen University Cancer Center
2024
State Key Laboratory of Oncology in South China
2024
First People's Hospital of Foshan
2024
Sun Yat-sen Memorial Hospital
2024
Harbin Medical University
2008-2020
Third Affiliated Hospital of Harbin Medical University
2001-2020
Jinan Military General Hospital
2018
To report long‐term results of a randomized controlled trial that compared cisplatin/fluorouracil/docetaxel (TPF) induction chemotherapy (IC) plus concurrent chemoradiotherapy (CCRT) with CCRT alone in locoregionally advanced nasopharyngeal carcinoma (NPC). Patients stage III–IVB (except T3–4 N0) NPC were randomly assigned to receive IC (n = 241) or 239). included three cycles docetaxel (60 mg/m 2 d1), cisplatin and fluorouracil (600 /d civ d1–5) every 3 weeks. from both groups received...
Abstract Nucleus- and cell-specific interrogation of individual basal forebrain (BF) cholinergic circuits is crucial for refining targets to treat comorbid chronic pain-like depression-like behaviour. As the ventral pallidum (VP) in BF regulates pain perception emotions, we aim address role VP-derived hyperalgesia behaviour mouse model. In male mice, VP neurons innervate local non-cholinergic modulate downstream basolateral amygdala (BLA) through nicotinic acetylcholine receptors. These are...
Superoxide dismutase 1(SOD1) is a major antioxidant with oncogenic effects in many human cancers. Although SOD1 overexpressed various cancers, the clinical significance and functions of non-small cell lung cancer (NSCLC), particularly epigenetic regulation NSCLC carcinogenesis progression have been less well investigated. In this study, we found that expression was upregulated lines tissues. Further, elevated could promote proliferation, invasion migration. While inhibition induced G1-phase...
Nimotuzumab is a humanized IgG1 monoclonal antibody specifically targeting EGFR. In this study, we aimed to investigate the molecular mechanisms of nimotuzumab in its effects enhancing cancer cell radiosensitivity.Lung A549 cells and breast MCF-7 were pretreated with or without for 24 h before radiation perform clonogenic survival assay analyze apoptosis by flow ctyometry. γ-H2AX foci detected confocal microscopy assess effect on induced DNA repair. EGFR activation was examined levels damage...
Nasopharyngeal carcinoma (NPC) is a rare malignancy in children and adolescents, the optimal treatment modality youths has not been established. The aim of this study was to evaluate long-term outcomes complications associated with childhood adolescent NPC.From January 1985 December 2004, records 95 patients NPC younger than 20 years age were reviewed. All confirmed based on pathology via biopsy. radiation doses primary tumors ranged from 64 80 Gy. metastatic cervical lymph nodes 60 74...
Radiation treatment remains one of the major modalities in lung cancer. Although majority patients initially respond to with radiation, resistance inevitably develops and leads failure. Therefore, identification underlying molecular mechanisms radiation may facilitate development novel approaches for overcoming resistance, enhance efficacy other types In present study we established three radiation‑resistant sub‑cell lines derived from radiation‑sensitive cancer cell line HCC827. Using a...
Fatty acid synthase (FASN) is the key enzyme required for de novo synthesis of long-chain fatty acids. FASN has been observed to be overexpressed in majority cancer tissues, and its expression associated with a poor prognosis, potentially mediated by resistance drug or radiation. The present study investigated whether downregulation non-small cell lung (NSCLC) may increase radiosensitivity. A lentiviral vector containing short hairpin RNA targeted (pSIH-H1-Puro-shFASN) was successfully...
To investigate the efficacy and safety of radiotherapy combined with targeted therapy immunotherapy for liver cancer lymph node metastasis (LNM). We analysed patients who received LNM in our hospital from June 2020 to 2023. 62 were enrolled this study, a median radiation dose 60.0 Gy, and/or immunotherapy. The objective response rate (ORR), overall survival (OS), progression free (PFS), adverse events observed evaluate treatment safety. With follow-up 18.5 months, best ORR was 90.3%. OS 26.0...
Much progress has been made in the understanding of neural circuits associated with sleep and anesthesia. As an important component among these circuits, forebrain nuclei have frequently interrogated. This study demonstrates that glutamatergic (Glu) neurons ventral pallidum (VP) enhance activity upon salient stimuli state-dependently modulate brain arousal motor freely behaving male mice, bidirectionally regulate induction emergence from isoflurane general We delineate a pathway, consisting...
This study aimed to quantify tumor volume reduction during radiotherapy for abdominal lymph node metastases (LNM) of hepatocellular carcinoma (HCC) and assess the potential benefits late-course adaptive radiotherapy. Forty HCC Patients with LNM treated from January 2021 March 2024 received in combination targeted therapy or immunotherapy. Second simulation scan was performed fourth week Two-thirds patients underwent redesigned plan as test group, while remaining continued original control...
Background Radiotherapy plays a critical role in the management of non-small cell lung cancer (NSCLC). This study was conducted to identify gene expression profiles acquired radioresistant NSCLC line established by fractionated ionizing radiation (FIR) cDNA microarray. Methods The human adenocarcinoma Anip973 treated with high energy X-ray receive 60 Gy 4 fractions. radiosensitivity Anip973R and its parental were measured clonogenic assay. Gene analyzed using microarray consisting 21 522...
Purpose To investigate the predictive role and association of nuclear survivin DNA double-strand breaks repair genes in non-small cell lung cancer (NSCLC): DNA-dependent protein kinase catalytic subunit (DNA-PKcs), Ku heterodimeric regulatory complex 70-KD (Ku70) ataxia-telangiectasia mutated (ATM). Methods The expression survivin, DNA-PKcs, Ku70 ATM were investigated using immunohistochemistry tumors from 256 patients with surgically resected NSCLC. Furthermore, we analyzed correlation...
Background/Aims: Survivin, a member of the inhibitor apoptosis protein family, is an attractive target for cancer therapy. We investigated effects YM155, small molecule survivin expression, on radiosensitivity human non-small cell lung (NSCLC) lines and elucidated relationship between cellular localization DNA double-strand break repair. Methods: The distribution was determined by Western blotting subcellular fractions immunofluorescent staining in A549 NSCLC cells. Radiation-induced damage...
Abstract Non–small‐cell lung cancer (NSCLC) is the most common cause of death from worldwide. MicroRNAs (miRNAs) are a group important regulators in NSCLC, including miR‐198. However, underlying molecular mechanisms miR‐198 involvement intrinsic resistance to radiotherapy NSCLC remain be elucidated. In this study, investigate clinical significance relation response radiotherapy, we determined expression patterns between responders and nonresponders after 2 months found that decreased...
Abstract Background To investigate the correlation between microinvasion and various features of hepatocellular carcinoma (HCC), to clarify distance from visible HCC lesions subclinical lesions, so as provide clinical basis for expandable boundary target volume (CTV) gross tumor (GTV) in radiotherapy HCC. Methods patients underwent hepatectomy liver cancer our hospital July 2019 November 2021 were enrolled. Data on collected. The distribution characteristics analyzed its potential with...
To examine the expression of astrocyte elevated gene-1 (AEG-1) in non-small-cell lung cancer (NSCLC) and analyse correlation between AEG-1 prognosis patients, particularly relationship postoperative chemotherapy radiotherapy.The was analysed by immunohistochemistry 225 primary NSCLC specimens 42 adjacent normal tissue specimens. Statistical analyses were performed to evaluate clinicopathological characteristics patients as well predictive value AEG-1.The associated with pathological stage (P...
In the present study, anticancer activity of chamaejasmine towards A549 human lung adenocarcinoma cells was investigated. order to explore underlying mechanism cell growth inhibition chamaejasmine, cycle distribution, ROS generation, mitochondrial membrane potential (Δψm) disruption, and expression cytochrome c, Bax, Bcl-2, caspase-3, caspase-9 PARP were measured in cells. Chamaejasmine inhibited a time dose-dependent manner. The IC50 value 7.72 µM after 72 h treatment. arrested G2/M phase...
Abstract: The aim of this work was to examine the expression cancerous inhibitor protein phosphatase 2A (CIP2A) in non-small cell lung cancer (NSCLC) and analyze its correlation with clinical outcomes. CIP2A levels were detected by immunohistochemistry (IHC). One hundred eighty-four 209 (88.3%) primary stage I–III NSCLC specimens 4 38 (10.5%) adjacent normal tissue expressed protein. High 38.8% (81/209) specimens. Patients diagnosed histologically late-stage ( p <0.001) malignant nodes...
Background: Lymph node necrosis (LNN), including retropharyngeal nodal and cervical necrosis, which is related to radiotherapy/ chemotherapy resistance, a common phenomenon in nasopharyngeal carcinoma (NPC). This study was assess the prognostic value of LNN at different N stages NPC patients. Materials Methods: In total, 1,665 newly diagnosed patients stage TxN1-3M0 from two centers were enrolled. Univariate multivariate models constructed association between long-term survival outcomes. The...
The objective of the study is to investigate effects Numb/Notch signal pathway on radiosensitivity lung cancer cell line H358. MTT assay and colony forming were used detect different doses X-rays MW167 in vitro proliferation Flow cytometry was applied evaluate X rays apoptosis Scratch Transwell invasion examine migration abilities mRNA protein expressions detected by real-time PCR western blot. Assays confirmed inhibitor cancer. enhanced inhibiting X-ray H358 line. After addition MW167,...