A5102714514- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Cell death mechanisms and regulation
- interferon and immune responses
- RNA modifications and cancer
- Microbial metabolism and enzyme function
- Circular RNAs in diseases
- RNA Research and Splicing
- Cancer, Hypoxia, and Metabolism
- Autophagy in Disease and Therapy
- Animal Virus Infections Studies
- Proteoglycans and glycosaminoglycans research
- DNA Repair Mechanisms
- Viral Infectious Diseases and Gene Expression in Insects
- Virus-based gene therapy research
- Heat shock proteins research
- Lung Cancer Research Studies
- Cancer-related Molecular Pathways
- Cell Adhesion Molecules Research
- NF-κB Signaling Pathways
- Extracellular vesicles in disease
- Mycobacterium research and diagnosis
- Nanoplatforms for cancer theranostics
- Glycosylation and Glycoproteins Research
- Wnt/β-catenin signaling in development and cancer
Harbin Medical University
2008-2024
Third Affiliated Hospital of Harbin Medical University
2008-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2008
Abstract Cold exposure (CE) therapy is an innovative and cost‐efficient cancer treatment that activates brown adipose tissue to compete for glucose uptake, leading metabolic starvation in tumors. Exploring the combined antitumor mechanisms of CE traditional therapies (such as nanocatalysis) exciting promising. In this study, a platelet membrane biomimetic single‐atom nanozyme (SAEs) nanodrug (PFB) carrying bis‐2‐(5–phenylacetamido‐1, 2, 4‐thiadiazol‐2‐yl) ethyl sulfide (BPTES) developed use...
Background/Aims: Radiation therapy is an important and effective modality for the treatment of non-small cell lung cancer (NSCLC). MicroRNAs (miRNAs) are crucial post-transcriptional regulators that involved in numerous biologic processes. However, their potential involvement radiation sensitivity remains unknown. Materials: We performed integrated analysis miRNA expression NSCLC using The Cancer Genome Atlas datasets. miR-99a was found to be significantly upregulated tissue regulated...
Long non-coding RNA H19 (lncRNA H19) has been implicated in tumorigenesis and metastasis of breast cancer through regulating epithelial to mesenchymal transition (EMT); however, the underlying mechanisms remain elusive.LncRNA TNFAIP8 were identified by qRT-PCR western blotting. CCK-8 assay, clone formation transwell flow cytometry assay performed determine cell proliferation, migration, invasion cycle respectively. Western blotting immunohistochemistry (IHC) utilized evaluate protein...
Background Radiotherapy plays a critical role in the management of non-small cell lung cancer (NSCLC). This study was conducted to identify gene expression profiles acquired radioresistant NSCLC line established by fractionated ionizing radiation (FIR) cDNA microarray. Methods The human adenocarcinoma Anip973 treated with high energy X-ray receive 60 Gy 4 fractions. radiosensitivity Anip973R and its parental were measured clonogenic assay. Gene analyzed using microarray consisting 21 522...
Purpose To investigate the predictive role and association of nuclear survivin DNA double-strand breaks repair genes in non-small cell lung cancer (NSCLC): DNA-dependent protein kinase catalytic subunit (DNA-PKcs), Ku heterodimeric regulatory complex 70-KD (Ku70) ataxia-telangiectasia mutated (ATM). Methods The expression survivin, DNA-PKcs, Ku70 ATM were investigated using immunohistochemistry tumors from 256 patients with surgically resected NSCLC. Furthermore, we analyzed correlation...
Decorin, chiefly synthesized by tumor stroma, is known as a suppressor. However, the clinical and prognostic significance in lung cancer remained unclear. Here, decorin Ki67 expression was detected immunohistochemistry (IHC) I–IIIA non-small cell (NSCLC) tissues (n = 264) comparison to adjacent normal 40). The relationship between of characteristics, well index prognosis, analyzed. Decorin decreased both stroma (P < 0.001) cells 0.038) NSCLC specimens. There lowest stromal patients with G3...
Abstract The aim of our study is to construct the competing endogenous RNA (ceRNA) network head and neck squamous cell carcinoma (HNSCC) identify key long noncoding RNAs (lncRNAs) predict prognosis. genes whose expression were differentially in HNSCC normal tissues explored by Cancer Genome Atlas database. ceRNA was constructed Cytoscape software. lncRNAs which could estimate overall survival from Cox proportional hazards regression. There are 1997, 589, 82 mRNAs, lncRNAs, miRNAs...
Tumor necrosis factor alpha-induced protein 8 (TNFAIP8) is implicated in the tumor progression and prognosis of triple-negative breast cancer (TNBC), but detailed regulatory mechanism TNFAIP8 cisplatin tolerance TNBC has not yet been investigated. was evidently upregulated tissues cell lines. Knocking down led to impaired proliferation elevated apoptosis cells upon (DDP) treatment. Mechanistic studies revealed that repressed expression p53 p53-promoted microRNA (miR)-205-5p; moreover,...
To evaluate the anti-tumor effects of NDV and two genes virus(HN F) on athymic mice with human adenocarcinoma xenografts, to investigate mechanisms its oncolytic role.The experimental model lung xenograft was established. The groups were given intratumoral injections plasmids only once, compared PBS controls in same time. Measure volume tumors for 5 weeks make a curve volume. These killed after weeks, weight measured. histological ultrastructral changes observed by electromicroscope...