A5100349504- MicroRNA in disease regulation
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Circular RNAs in diseases
- Cancer, Hypoxia, and Metabolism
- Angiogenesis and VEGF in Cancer
- Epigenetics and DNA Methylation
- Liver Disease Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Medical Research and Treatments
- Traditional Chinese Medicine Studies
- Cancer-related gene regulation
- Pharmacological Effects of Natural Compounds
- Healthcare and Venom Research
- Nanoporous metals and alloys
- Mitochondrial Function and Pathology
- Cancer-related Molecular Pathways
- Neuroscience of respiration and sleep
- Metabolism and Genetic Disorders
- Eicosanoids and Hypertension Pharmacology
- PI3K/AKT/mTOR signaling in cancer
- Pediatric health and respiratory diseases
- Ferroptosis and cancer prognosis
Shanghai Pulmonary Hospital
2025
Tongji University
2025
Weatherford College
2025
Central South University
2015-2025
Nanjing Medical University
2007-2025
University of South China
2024-2025
Wuhan Institute of Technology
2025
Dali University
2025
Peking Union Medical College Hospital
1997-2025
Army Medical University
2003-2025
Abstract Reactive oxygen species (ROS) are associated with multiple cellular functions such as cell proliferation, differentiation, and apoptosis. However, the direct roles of endogenous ROS production still remain to be elucidated. In this study, we found that high levels were spontaneously produced by ovarian prostate cancer cells. This elevated was inhibited NADPH oxidase inhibitor diphenylene iodonium (DPI) mitochondria electron chain rotenone in To further analyze source production,...
MicroRNAs (miRNAs) are endogenous, small noncoding RNAs that play important roles in various cellular functions and tumor development. Recent studies have indicated miR-21 is one of the miRNAs associated with growth metastasis, but role molecular mechanism regulating angiogenesis remain to be elucidated. In this study, was overexpressed by transfecting pre-miR-21 into human prostate cancer cells assayed using chicken chorioallantoic membrane (CAM). We found overexpression DU145 increased...
Abstract Purpose: To investigate expression, regulation, potential role and targets of miR-195 miR-497 in breast cancer. Experimental Design: The expression patterns were initially examined cancer tissues cell lines by Northern blotting quantitative real-time PCR. Combined bisulfite restriction analysis sequencing carried out to study the DNA methylation status genes. Breast cells stably expressing established their targets. Finally, normal, fibroadenoma employed analyze correlation between...
MiR-145 can regulate cell apoptosis, proliferation, neural development and stem differentiation. Previous studies indicate that miR-145 is downregulated in human colon cancer cells. However, the molecular mechanisms of used to carcinogenesis angiogenesis remain be clarified. Here, we show expression ovarian tissues lines. inhibits p70S6K1 post-transcriptional by binding its 3'-UTR. The angiogenic factors hypoxia-inducible factor 1 (HIF-1) vascular endothelial growth (VEGF), which are...
Dysregulation of microRNAs is a common feature in human cancers, including breast cancer (BC). Here we describe the epigenetic regulation miR-148a and miR-152 their impact on BC cells. Due to hypermethylation CpG island, expression levels both (miR-148a/152) are decreased tissues DNMT1, DNA methyltransferase 1 for maintenance methylation, aberrantly up-regulated its overexpression responsible promoters. Intriguingly, found that DNMT1 expression, which one targets miR-148a/152, inversely...
Apigenin is a non-toxic dietary flavonoid with anti-tumor properties. We recently showed that apigenin-inhibited hypoxia-inducible factor-1 (HIF-1) and vascular endothelial growth factor (VEGF) expression in human ovarian cancer cells under normoxic condition. However, the effect of apigenin angiogenesis remains to be elucidated. Angiogenesis formation new blood vessels required for tumor metastasis. In this study, we HIF-1 VEGF different both hypoxic conditions. demonstrated significantly...
Cadmium is categorized as a human carcinogen especially involved in lung cancers. Angiogenesis considered fundamental requirement for tumorigenesis, but the mechanisms underlying tumor angiogenesis induced by cadmium are poorly understood. Using vitro and vivo models, we investigated angiogenic of bronchial epithelial cells formation. Our results demonstrated that (CdCl2) activated extracellular signal-regulated kinases (ERK) AKT signaling elevated expression key downstream proangiogenic...
Apigenin is a natural dietary flavonoid. It has recently been shown to have anticancer effects on prostate and ovarian cancer cells. However, the molecular basis of effect apigenin cells remains be elucidated. In this study, we found that inhibited A549 lung cell proliferation vascular endothelial growth factor (VEGF) transcriptional activation in dose-dependent manner. an attempt understand mechanism apigenin-inhibited VEGF expression, through hypoxia-inducible 1 (HIF-1) binding site...
Abstract Cisplatin [cis-diaminodichloroplatinum (II) (CDDP)] is one of the most widely used and effective therapeutic agents for many kinds cancers. However, its efficiency limited due to development drug resistance. In this study, we showed that CDDP resistance was associated with AKT1 overexpression gene amplification in human lung cancer cells acquired We forced expression sufficient render resistant, inhibition by dominant negative mutant reversed CDDP-resistant be sensitive. These...
Ovarian cancer is 1 of the most significant malignancies in Western world, and antiangiogenesis strategy has been postulated for prevention treatment ovarian cancers. Kaempferol a natural flavonoid present many fruits vegetables. The potential kaempferol its underlying mechanisms were investigated two cell lines, OVCAR-3 A2780/CP70. mildly inhibits viability but significantly reduces VEGF gene expression at mRNA protein levels both lines. In chorioallantoic membranes chicken embryos,...
Cisplatin is commonly used in ovarian cancer treatment by inducing apoptosis cells as a result of lethal DNA damage. However, the intrinsic and acquired resistance to cisplatin remains big challenge for improving overall survival. The cyto-protective functions autophagy have been suggested potential mechanism chemoresistance. Here, we reported MIR152 new autophagy-regulating miRNA that plays role cisplatin-resistance. We showed expression was dramatically downregulated cisplatin-resistant...
MicroRNAs are a class of small noncoding RNAs that function as critical gene regulators through targeting mRNAs for translational repression or degradation. In this study, we showed miR-128 expression levels were decreased in glioma, and identified p70S6K1 novel direct target miR-128. Overexpression suppressed its downstream signaling molecules such HIF-1 VEGF expression, attenuated cell proliferation, tumor growth angiogenesis. Forced can partly rescue the inhibitory effect cells. Taken...
Colorectal cancer (CRC) is one of the leading cancer-related causes death in world. Recently, downregulation microRNA-143 (miR-143) has been observed CRC tissues. Here this study, we found that miR-143 expression was downregulated both patients' blood samples and tumor specimens. MiR-143 levels were strongly correlated with clinical stages lymph node metastasis. Furthermore, insulin-like growth factor-I receptor (IGF-IR), a known oncogene, novel direct target miR-143, whose inversely human...
Epithelial–mesenchymal transition (EMT) has been recognized as a key element of cell migration and invasion in lung cancer; however, the underlying mechanisms are not fully elucidated. Recently, emerging evidence suggest that miRNAs have crucial roles control EMT EMT-associated traits such migration, chemoresistance. Here, we found miR-218 expression levels were significantly downregulated cancer tissues compared with adjacent non-cancerous tissues, associated histological grades lymph node...
MiR-145 is known as a tumor suppressor in numerous human cancers. However, its role angiogenesis remains poorly defined. In this study, we found that miR-145 was significantly downregulated breast cancer tissues by using 106 cases of normal and well cells. exhibited inhibitory angiogenesis, cell growth invasion through the post-transcriptional regulation novel targets N-RAS VEGF-A. addition, provide evidence expression levels correlate inversely with malignancy stages tumors, although there...
// Lin Wang 1,* , Zhu-mei Shi 1,2,* Cheng-fei Jiang Xue Liu 1 Qiu-dan Chen Xu Qian Dong-mei Li Xin Ge Xie-feng 2 Ling-Zhi 3 Yong-ping You Ning and Bing-Hua 1,3 State Key Lab of Reproductive Medicine, Department Pathology, Nanjing Medical University, Nanjing, China Neurosurgery, The First Affiliated Hospital Anatomy Cell Biology, Thomas Jefferson Philadelphia, USA * These authors contributed equally to this work Correspondence: Jiang, email: Liu, Keywords : miR-143, N-RAS, tumor growth,...