A5058484759- Retinal Development and Disorders
- Retinal Diseases and Treatments
- Cancer-related molecular mechanisms research
- Pancreatic and Hepatic Oncology Research
- Plant Virus Research Studies
- Plant and Fungal Interactions Research
- Pancreatitis Pathology and Treatment
- RNA modifications and cancer
- Advanced biosensing and bioanalysis techniques
- Retinoids in leukemia and cellular processes
- Bone Metabolism and Diseases
- Glaucoma and retinal disorders
- Bone health and osteoporosis research
- RNA regulation and disease
- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- Natural product bioactivities and synthesis
- RNA Interference and Gene Delivery
- Genomics and Phylogenetic Studies
- Bioactive Compounds and Antitumor Agents
- Folate and B Vitamins Research
- Metabolism, Diabetes, and Cancer
- Lipid metabolism and disorders
- Retinal and Macular Surgery
- Bioactive natural compounds
Shenyang Pharmaceutical University
2024-2025
National Institutes for Food and Drug Control
2025
Shaoxing People's Hospital
2025
Affiliated Hospital of Southwest Medical University
2018-2024
Zhejiang University
2024
Dalian Medical University
2017-2024
Nankai University
2024
Huazhong University of Science and Technology
2024
Chinese Academy of Agricultural Sciences
2024
Oil Crops Research Institute
2024
Apigenin is a non-toxic dietary flavonoid with anti-tumor properties. We recently showed that apigenin-inhibited hypoxia-inducible factor-1 (HIF-1) and vascular endothelial growth factor (VEGF) expression in human ovarian cancer cells under normoxic condition. However, the effect of apigenin angiogenesis remains to be elucidated. Angiogenesis formation new blood vessels required for tumor metastasis. In this study, we HIF-1 VEGF different both hypoxic conditions. demonstrated significantly...
Osteoporosis is a major public health problem. It mainly characterized by low bone mineral density (BMD) and/or low-trauma osteoporotic fractures (OF), both of which have strong genetic determination. The specific genes influencing these phenotypic traits, however, are largely unknown. Using the Affymetrix 500K array set, we performed case-control genome-wide association study (GWAS) in 700 elderly Chinese Han subjects (350 with hip OF and 350 healthy matched controls). A follow-up...
Abstract The co-infection of Maize chlorotic mottle virus (MCMV) and Sugarcane mosaic (SCMV) can cause maize lethal necrosis. However, the mechanism underlying synergistic interaction between these two viruses remains elusive. In this study, we found that MCMV SCMV increased accumulation MCMV. Moreover, profiles virus-derived siRNAs (vsiRNAs) from in single- co-infected plants were obtained by high-throughput sequencing. Our data showed infection remarkably vsiRNAs MCMV, which mainly 22 21...
The global outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) urgently requires an effective vaccine for prevention. In this study, 66 epitopes containing pentapeptides SARS-CoV-2 spike protein in the IEDB database were compared with amino acid sequence protein, and potentially immune-related peptides obtained. Based on single-nucleotide polymorphisms analysis 1218 isolates, 52 easily mutated sites identified used epitope screening. best candidate screened out through...
Abstract Background Patients with acute pancreatitis (AP) exhibit specific phenotypes of gut microbiota associated severity. Gut and host interact primarily through metabolites; regrettably, little is known about their roles in AP biological networks. This study examines how enterobacterial metabolites modulate the innate immune system aggravation. Methods In AP, alterations were detected via microbiomics, Lactobacillus tryptophan identified by liquid chromatography-tandem mass spectrometry...
The intestinal barrier injury caused by severe acute pancreatitis (SAP) can induce enterogenous infection, further aggravating the inflammatory reactions and immune responses. This study aimed to test hypothesis that emodin protects function is involved in response SAP.The network pharmacology was established using Swiss target prediction pathway enrichment analysis. SAP mice model induced cerulein (50 μg/kg) lipopolysaccharide (10 mg/kg) hyperstimulation. pharmacological effect of treating...
Stomach adenocarcinoma (STAD) is a malignant tumor with high histological heterogeneity. However, the potential mechanism of STAD tumorigenesis remains to be elucidated. The purpose our research was identify candidate genes associated diagnosis, progression, prognosis, and immunotherapeutic targets STAD. Based on samples from GSE28541 dataset, weighted gene co-expression network analysis revealed 16 modules related stage grade. salmon module emerged as most relevant (cor = 0.34), functional...
Streptococcus thermophilus MN-ZLW-002 was originally isolated from traditionally fermented Chinese dairy products. One of the strain-dependent characteristics this bacterium is its ability to produce exopolysaccharides (EPSs). This study determined and analyzed genome sequence MN-ZLW-002. Its complete comprised 2,046 genes 1,848,520 nucleotides with an average GC content 39%. The EPS cluster includes 25 open reading frames (ORFs), some results indicate a horizontal gene transfer between...