A5100325267- Nanoplatforms for cancer theranostics
- Advanced Sensor and Energy Harvesting Materials
- Geotechnical Engineering and Soil Stabilization
- Immune Cell Function and Interaction
- Thermography and Photoacoustic Techniques
- Plasmonic and Surface Plasmon Research
- Mesenchymal stem cell research
- Assembly Line Balancing Optimization
- Geotechnical Engineering and Underground Structures
- Acoustic Wave Phenomena Research
- Photoacoustic and Ultrasonic Imaging
- Nonlinear Optical Materials Studies
- Advanced Manufacturing and Logistics Optimization
- Gestational Trophoblastic Disease Studies
- Analog and Mixed-Signal Circuit Design
- Nuclear Materials and Properties
- Scheduling and Optimization Algorithms
- Nuclear reactor physics and engineering
- Robotic Locomotion and Control
- Hepatitis B Virus Studies
- Immunotherapy and Immune Responses
- Phagocytosis and Immune Regulation
- Low-power high-performance VLSI design
- Luminescence and Fluorescent Materials
- Photonic and Optical Devices
Dalian Medical University
2021-2025
Wuhan University of Technology
2024-2025
Tongji University
2023-2025
Shandong University
2021-2024
Lanzhou University
2024
Public Health Ontario
2024
Shandong University of Traditional Chinese Medicine
2024
Affiliated Hospital of Liaoning University of Traditional Chinese Medicine
2024
Xi'an Jiaotong University
2017-2024
University of Toronto
2024
Hepatocellular carcinoma (HCC) is one of the most deadly cancers worldwide and has no effective treatment, yet molecular basis hepatocarcinogenesis remains largely unknown. Here we report findings from a whole-genome sequencing (WGS) study 88 matched HCC tumor/normal pairs, 81 which are Hepatitis B virus (HBV) positive, seeking to identify genetically altered genes pathways implicated in HBV-associated HCC. We find beta-catenin be frequently mutated oncogene (15.9%) TP53 tumor suppressor...
Increasing evidence shows that metabolic factors are involved in the pathological process of osteoarthritis (OA). Lactate has been shown to contribute onset and progression diseases. While whether lactate is pathogenesis OA through impaired chondrocyte function its mechanism remains unclear. This study confirmed serum levels were elevated patients compared healthy controls positively correlated with synovial fluid levels, which also fasting blood glucose, high-density lipoprotein,...
Herpes zoster remains an important global health issue and mainly occurs in aged immunocompromised individuals with early exposure history to Varicella Zoster Virus (VZV). Although the licensed vaccine Shingrix has a remarkably high efficacy, undesired reactogenicity increasing demand causing shortage urged development of improved or novel VZV vaccines. In this study, we developed mRNA candidate (named as ZOSAL) containing sequence-optimized mRNAs encoding full-length glycoprotein E...
We report on the first study to track spatial behaviors of wild giant pandas (Ailuropoda melanoleuca) using high-resolution global positioning system (GPS) telemetry. Between 2008 and 2009, 4 (2 male 2 female) were tracked in Foping Reserve, China for an average 305 days (± 54.8 SE). Panda home ranges larger than those previous very high frequency tracking studies, with a bimodal distribution space-use distinct winter summer centers activity. Home range sizes summer, although there was...
Plasmonic gap mode in metal-insulator-metal (MIM) structure has proven promising for refractive index sensing due to its near unity absorption. However, the performance of been limited by broad resonance band, which is related high plasmonic loss. In this work, square-patch-based MIM structures are used simultaneous excitation both surface plasmon polariton and Rayleigh anomaly with large absorptions, demonstrate their excellent performances. For anomaly, sensitivity full width half-maximum...
Abstract White‐light emitting elastomers (WLEEs) based on stimuli‐responsive aggregation‐induced emission (AIE) and regulated Förster resonance energy transfer (FRET) have aroused increasing attention due to the demands for wearable optoelectronic devices. Herein, blue orange AIEgens with different environmental sensitivities are synthesized then encapsulated both sides of nanofibers via side‐by‐side electrospinning aiming achieve Janus WLEEs. After regulating blue‐orange ratio, efficient...
Microparticles are successfully engineered through controlled interfacial self-assembly of polymers to harmonize ultrahigh drug loading with zero-order release protein payloads. To address their poor miscibility carrier materials, molecules transformed into nanoparticles, whose surfaces covered polymer molecules. This layer hinders the transfer cargo nanoparticles from oil water, achieving superior encapsulation efficiency (up 99.9%). control payload release, density at oil-water interface...
Abstract Cancer immunotherapy is revolutionary in oncology and hematology. However, a low response rate restricts the clinical benefits of this therapy owing to inadequate T lymphocyte infiltration delivery efficiency immunotherapeutic drugs. Herein, an intelligent nanovehicle (folic acid (FA)/1‐(4‐(aminomethyl) benzyl)‐2‐butyl‐1H‐imidazo[4,5‐c]quinolin‐4‐amine (IMDQ)‐oxaliplatin (F/IMO)@CuS) armed with multifunctional navigation designed for accurate cargoes tumor cells dendritic (DCs),...
Abstract Persistent inflammation and disrupted immunoregulation are critical factors in impeding diabetic wound healing. While immunoregulatory hydrogel dressings hold significant promise for clinical applications healing, the current application often demands intricate interventions high‐cost treatments involving cytokines cell therapies. The development of single component hydrogels remains a complex challenge. To address this issue, an active peptide with properties targeting TLR4/NF‐kB...
A star-shaped glycosylated conjugated oligomer, 4,4′,4″-tris(4-(2-(4-(benzo[d]thiazol-2-yl)phenyl)-9,9′-bis(6-thiol-β-d-glucose)-hexyl)-fluoren-7-yl)phenylamine (TFBS), is synthesized for two-photon fluorescence imaging of live cells. The high density hydrophilic sugar side groups induces self-assembly TFBS into nanoparticles in water with an average diameter 61 nm. Because the self-assembled nanostructure, has a higher quantum yield (Φ = 0.10), compared to its cationic counterpart,...
Exosomes play crucial roles in cell-cell communication, but few studies exist on the role of exosomal miRNA interaction between peritoneal macrophages (pMφ) and human ectopic endometrial stromal cells (eESCs) endometriosis (EMS). This study aimed to identify which miRNAs are significantly differently produced from EMS pMφ investigate functional eESCs.Exosomes were collected culture media by differential centrifugation. Confocal microscopy was used whether exosomes secreted can be delivered...
Abstract Stromal vascular fraction (SVF) cells are used clinically for various therapeutic targets. The location and persistence of engrafted SVF important parameters determining treatment failure versus success. We the GID SVF-1 platform a clinical protocol to harvest label with fluorinated (19F) agent CS-1000 as part first-in-human phase I trial (clinicaltrials.gov identifier NCT02035085) track magnetic resonance imaging during radiation-induced fibrosis in breast cancer patients. Flow...
Stomach adenocarcinoma (STAD) is a malignant tumor with high histological heterogeneity. However, the potential mechanism of STAD tumorigenesis remains to be elucidated. The purpose our research was identify candidate genes associated diagnosis, progression, prognosis, and immunotherapeutic targets STAD. Based on samples from GSE28541 dataset, weighted gene co-expression network analysis revealed 16 modules related stage grade. salmon module emerged as most relevant (cor = 0.34), functional...