A5100445632- Nanoplatforms for cancer theranostics
- Neonatal Respiratory Health Research
- Cannabis and Cannabinoid Research
- Neurotransmitter Receptor Influence on Behavior
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Neuroscience and Neuropharmacology Research
- Photodynamic Therapy Research Studies
- Immune Cell Function and Interaction
- Immune cells in cancer
- Advanced Biosensing Techniques and Applications
- Autophagy in Disease and Therapy
- Advanced Proteomics Techniques and Applications
- Seaweed-derived Bioactive Compounds
- Cancer Immunotherapy and Biomarkers
- Olfactory and Sensory Function Studies
- T-cell and B-cell Immunology
- Biochemical Analysis and Sensing Techniques
- Nanoparticle-Based Drug Delivery
- Advanced Chemical Sensor Technologies
- Nuclear Receptors and Signaling
- Neonatal and fetal brain pathology
- Mass Spectrometry Techniques and Applications
- Phagocytosis and Immune Regulation
- Saffron Plant Research Studies
Shandong University
2004-2024
Tianjin University
2023-2024
Xiamen University
2024
Ludwig-Maximilians-Universität München
2024
Dalian Medical University
2021-2022
China University of Geosciences
2022
Institute of Hydrobiology
2022
Chinese Academy of Sciences
2022
Chongqing Medical University
2022
Jinan Maternity And Care Hospital
2021
In order to explore potential therapeutic implications of cannabinoid antagonists, the effects prototypical antagonist SR141716A on monoamine efflux from medial prefrontal cortex and nucleus accumbens rat were investigated by in vivo microdialysis. moderately increased serotonin concentrations its metabolite 5‐HIAA, both accumbens, norepinephrine, dopamine their metabolites cortex. contrast, it had no effect accumbens. At same doses, acetylcholine cortex, agreement with previous studies;...
Blockade of cannabinoid CB 1 receptors has been reported to inhibit cocaine- or cocaine cue-induced reinstatement drug seeking. However, the mechanisms underlying this action are poorly understood. Given importance dopamine, glutamate, and GABA in reward relapse, we studied effects AM251 [ N -(piperidin-1-yl)-5-(4-iodophonyl)-1-(2,4-dichlorophenyl)-4-methyl-1 H -pyrazole-3-carboxamide], a novel highly selective receptor antagonist, on cocaine-primed drug-seeking behavior cocaine-induced...
Abstract Cancer immunotherapy is revolutionary in oncology and hematology. However, a low response rate restricts the clinical benefits of this therapy owing to inadequate T lymphocyte infiltration delivery efficiency immunotherapeutic drugs. Herein, an intelligent nanovehicle (folic acid (FA)/1‐(4‐(aminomethyl) benzyl)‐2‐butyl‐1H‐imidazo[4,5‐c]quinolin‐4‐amine (IMDQ)‐oxaliplatin (F/IMO)@CuS) armed with multifunctional navigation designed for accurate cargoes tumor cells dendritic (DCs),...
Abstract Agonists of innate pattern recognition receptors such as toll‐like (TLRs) prime adaptive anti‐tumor immunity and hold promise for cancer immunotherapy. However, small‐molecule TLR agonists cause immune‐related adverse effects (irAEs) after systemic administration. Herein, we report a polymeric nano‐immunomodulator (cN@SS‐IMQ) that is inactive until it selectively metabolized to an active immunostimulant within the tumor. cN@SS‐IMQ was obtained via self‐assembly...
Abstract In situ anti‐tumor vaccination is an attractive type of cancer immunotherapy which relies on the effectiveness dendritic cells (DCs) to engulf tumor antigens, become activated, and present antigens T in lymphoid tissue. Here, a multifunctional nanocomplex based calcium crosslinked polyaspartic acid conjugated either toll‐like receptor (TLR)7/8 agonist or photosensitizer reported. Intratumoral administration followed by laser irradiation induces cell killing hence generation pool...
Pulmonary fibrosis (PF) is the pathological structure of incurable fibroproliferative lung diseases that are attributed to repeated injury-caused failure alveolar regeneration (LAR). Here, we report repetitive damage results in a progressive accumulation transcriptional repressor SLUG epithelial type II cells (AEC2s). The abnormal increased inhibits AEC2s from self-renewal and differentiation into I (AEC1s). We found elevated represses expression phosphate transporter SLC34A2 AEC2s, which...
Monodispersed nanosized yttrium aluminum garnet (YAG) powder was synthesized via a mixed‐solvent thermal method using stoichiometric amounts of inorganic and salts. Pure‐phase YAG crystalline obtained at low temperature (290°C) pressure (10 MPa). The resulting products were characterized by X‐ray diffraction (XRD), infrared, transmission electron microscopy (TEM). XRD results showed that single‐phase could be formed directly from an amorphous precursor 280°C become fully developed 290°C. TEM...
Problem Estradiol (E2) deficiency can cause bone loss and the skew of Th1/Th2 cells. However, correlation between cells induced by estrogen remains unclear. Our aim was to investigate role in elucidated therapeutical effect catalpol this condition. Method Study Young, sham-operated (Sham), ovariectomized (Ovx), naturally aged mice, treated with at different doses or control vehicle, were used study as indicated each experiment. ELISA assay, dual-energy X-ray absorptiometry, flow cytometry...
A practical and economical K2S2O8-mediated oxidative cross-dehydrogenative coupling of N-aryl glycine derivatives with olefins has been established, affording structurally diverse quinoline-2-carboxylates in good to high efficiency. The low cost, negligible toxicity, ease handling K2S2O8 combined the absence hazardous byproducts easy workup consisting simple filtration are attractive based on economic environmental factors.
Lung cancer remains a leading cause of cancer-related deaths globally, and significant number patients are ineligible for surgery, while chemoradiotherapy often shows limited efficacy, systemic distribution, low drug concentration at tumor sites, severe side effects, the emergence resistance. In this context, nanodrug delivery system (NDDS) has emerged as promising approach lung treatment, offering distinct advantages such targeted delivery, responsiveness to microenvironment, site-specific...
Iguratimod (IGU) is a novel disease modified anti-rheumatic drug, which has been found to act directly on B cells for inhibiting the production of antibodies in rheumatoid arthritis (RA) patients. Follicular helper T (Tfh) cells, key cell subsets supporting differentiation and antibody production, have shown play critical roles RA. However, whether IGU can inhibit RA Tfh further restrains function remains unclear. Here, we aimed explore regulating circulating (cTfh) investigate potential...
Abstract Nuclear receptor subfamily 4 group A member 1 ( NR 4A1) is an orphan nuclear with diverse functions. It has been reported that 4A1, as a transcriptional activator, implicated in glucose and lipid metabolism. The aim of this study was to investigate the regulatory role 4A1 adipogenesis explore underlying mechanisms. Quantitative real‐time PCR Western blotting were used analyse expression genes involved synthesis mobilization fats vivo vitro. Dual‐luciferase reporter assay conducted...