A5007844508- Ion channel regulation and function
- Cardiac electrophysiology and arrhythmias
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Graphene and Nanomaterials Applications
- Colorectal Cancer Treatments and Studies
- Computational Drug Discovery Methods
- RNA modifications and cancer
- RNA Research and Splicing
- Genetic factors in colorectal cancer
- CRISPR and Genetic Engineering
- Graphene research and applications
- Cancer-related molecular mechanisms research
- Biochemical Analysis and Sensing Techniques
- Gastric Cancer Management and Outcomes
- PARP inhibition in cancer therapy
- Advanced Chemical Sensor Technologies
- Adipose Tissue and Metabolism
- Olfactory and Sensory Function Studies
- Protein Structure and Dynamics
- Advanced biosensing and bioanalysis techniques
- Mass Spectrometry Techniques and Applications
- Peroxisome Proliferator-Activated Receptors
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
Soochow University
2014-2024
The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital)
2024
Xinjiang Medical University
2017-2024
First Affiliated Hospital of Kunming Medical University
2021-2023
Kunming Medical University
2021-2023
State Key Laboratory of Solidification Processing
2023
Northwestern Polytechnical University
2023
Bio-Rad (United States)
2019
Suzhou Research Institute
2018
China Pharmaceutical University
2016-2018
With the development of hypersonic vehicles technology, ceramic based radome materials are highly demanded due to their high operating temperatures, good dielectric properties, and mechanical properties. Although α-SiAlON is an ideal material for application, its intrinsic low transmittance thermal conductivity limit application. Herein, we prepared Y-α-SiAlON porous ceramics through tert-butanol gel-casting using self-synthesised powder. exhibited a uniform micron-level connected pore...
Abstract Yes-associated protein (YAP) is a central player in cancer development, with functions extending beyond its recognized role cell growth regulation. Recent work has identified link between YAP/transcriptional coactivator PDZ-binding motif (TAZ) and the DNA damage response. Here, we investigated mechanistic underpinnings of cross-talk repair YAP activity. Ku70, key component nonhomologous end joining pathway to damage, engaged dynamic competition TEAD4 for binding YAP, limiting...
Titanium dioxide (TiO2) is probably one of the most widely used nanomaterials, and its extensive exposure may result in potentially adverse biological effects. Yet, underlying mechanisms interaction involving TiO2 NPs macromolecules, e.g., proteins, are still not well understood. Here, we perform all-atom molecular dynamics simulations to investigate interactions between twenty standard amino acids aqueous solution exploiting a newly developed force field. We found that charged play dominant...
Molybdenum disulfide (MoS2) nanomaterial has recently found various applications in the biomedical field mainly due to its outstanding physicochemical properties. However, little is known about interactions with biological systems at atomic level, which intimately relates biocompatibility of material. To provide insights into effects MoS2 entities, we investigated proteins from a functionally important membrane family, ubiquitous potassium (K+) channels. Here, study four representative K+...
Abstract Inwardly rectifying K + (Kir) channels, serving as natural molecular nanomachines, transport potassium ions across the plasma membrane of cell. Along ion permeation pathway, three relatively narrow regions (the selectivity filter (SF), inner helix bundle crossing (HBC), and cytosolic G loop) may serve gates to control permeation. Our previous dynamics simulations based on crystal structure a Kir3.1 chimera revealed possible gating mechanism loop gate. Here, we introduced proline...
Abstract As a major effective component in green tea, (−)-epigallocatechin-3-gallate (EGCG)’s potential benefits to human health have been widely investigated. Recent experimental evidences indicate that EGCG can induce the aggregation of HMGB1 protein, late mediator inflammation, which subsequently stimulates autophagic degradation and thus provides protection from lethal endotoxemia sepsis. In this study, we use molecular dynamics (MD) simulations explore underlying mechanism facilitated...
Inwardly rectifying potassium channels enforce tight control of resting membrane potential in excitable cells. The Kir3.2 channel, a member the Kir3 subfamily G-protein-activated (GIRKs), plays several roles nervous system, including key responsibility GABA B pathway inhibition, pain perception pathways via opioid receptors, and is also involved alcoholism. PKC phosphorylation acts on channel to reduce activity, yet mechanism incompletely understood. Using heterologous Xenopus oocyte system...
Recent studies have indicated that graphene and its derivative oxide (GO) engage in a wide range of antibacterial activities with limited toxicity to human cells. Here, we systematically evaluate the dependence GO on size nanoparticles used treatments: compare cytotoxic effects quantum dots (GQDs, <15 nm), small GOs (SGOs, 50–200 large (LGOs, 0.5–3 μ m). We synthesize results bacterial colony count assays SEM-based observations morphological changes assess properties these bring into...
Molecular dynamics simulations and electrophoresis experiments show that dsDNA can form a stable binding on the phosphorene surface through terminal base pairs adopt an upright orientation regardless of its initial configurations.
Effects of N-geranyl cyclopropyl-carboxamide (NGCC) and four structurally related compounds (N-cyclopropyl E2,Z6-nonadienamide, isobutanamide, 2-methylbutanamide, allyl carbamate) were evaluated on the chorda tympani (CT) nerve response to NaCl monosodium glutamate (MSG) in rats wild-type (WT) TRPV1 knockout (KO) mice human salty umami taste intensity. NGCC enhanced rat CT 100 mM + 5 μM benzamil (Bz; an epithelial Na(+) channel blocker) between 1 2.5 inhibited it above μM....
Inwardly rectifying K+ (Kir) channels set the resting membrane potential and regulate cellular excitability. The activity of Kir depends critically on phospholipid PIP2. molecular mechanism by which PIP2 regulates channel gating is poorly understood. Here, we utilized a combination computational electrophysiological approaches to discern structural elements involved in regulating PIP2-induced kinetics Kir2 channels. We identify novel role for cytosolic GH loop. Mutations that directly or...