A5100454119- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA modifications and cancer
- MicroRNA in disease regulation
- RNA Research and Splicing
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Mycobacterium research and diagnosis
- Pregnancy and preeclampsia studies
- Pulmonary Hypertension Research and Treatments
- Endometriosis Research and Treatment
- Reproductive System and Pregnancy
- Immune Response and Inflammation
- Reproductive Biology and Fertility
- Research in Cotton Cultivation
- Hops Chemistry and Applications
- Diet and metabolism studies
- Reproductive Physiology in Livestock
- Plant Molecular Biology Research
- Cleft Lip and Palate Research
- Kruppel-like factors research
- Sepsis Diagnosis and Treatment
- Metabolism and Genetic Disorders
- Head and Neck Cancer Studies
- Colorectal Cancer Treatments and Studies
- Heat shock proteins research
Dazhou Central Hospital
2018-2025
Maternal and Child Health Hospital of Xuzhou
2017-2024
South China Agricultural University
2020-2024
Hebei Agricultural University
2024
Harbin Medical University
2020-2024
Xuzhou Medical College
2017-2024
Guangdong Medical College
2023
Guangdong Academy of Agricultural Sciences
2022
Zhongnan Hospital of Wuhan University
2022
Wuhan University
2022
Background The efficacy of cisplatin-based chemotherapy in non-small-cell lung cancer is limited by the acquired drug resistance. Identification RNAs related to cisplatin resistance may help improve clinical response rates. Methods Microarray expression profiling mRNAs, lncRNA and miRNA was undertaken A549 cells resistant A549/CDDP cells. Differentially expressed lncRNAs miRNAs, verified realtime RT-PCR, were subjected pathway analysis. Expression NKD2 β-catenin assessed RT-PCR western blot...
Long non-coding RNAs (lncRNAs) have previously been implicated in human disease states, especially cancer.Although the aberrant expression of lncRNAs has observed cancer, biological functions and molecular mechanisms underlying aberrantly expressed hepatocellular carcinoma (HCC) not widely established.In present study, we investigated a novel lncRNA, termed URHC (up-regulated carcinoma), evaluated its role progression HCC.Expression profiling using lncRNA microarray revealed that was highly...
JARID1B is a member of the family JmjC domain-containing proteins that removes methyl residues from methylated lysine 4 on histone H3 (H3K4). has been proposed as an oncogene in many types tumors; however, its role and underlying mechanisms hepatocellular carcinoma (HCC) remain unknown. Here we show elevated HCC expression level positively correlated with metastasis. In addition Kaplan-Meier survival analysis showed high was associated decreased overall patients. Overexpression cells...
Macrophage polarization plays an important role in tumor microenvironment, which regulated the prognosis of prostate cancer. However, potential it is still need further identification.The M1 Macrophages were inducted using 100 ng/mL LPS and IFN-γ, 20 IL-4. TAMs obtained by culturing monocytes for 7 days RPMI 1640 10% FBS with 50% conditioned medium from PC-3 cells real-time PCR was performed to determine expression miR-148a, CCAT1, PKCζ. Western blot used measure level The cytokine IL-10...
Recently, long noncoding RNAs (lncRNAs) have been shown to play significant regulatory roles in human tumorigenesis. However, the biological function of lncRNAs cholangiocarcinoma (CCA) remains largely unknown. In this study, DANCR was be significantly upregulated CCA. regulated proliferation and migration CCA cells vitro. Moreover, downregulation suppressed vivo. RNA-seq revealed that knockdown preferentially affected genes linked with cell differentiation. Furthermore, mechanistic...
Cervical cancer (CC), causing significant morbidity and mortality worldwide, is one of the most common gynecological malignancies in women. SFN has been reported as a potential prognostic marker with apparent high expression tumors. Nevertheless, function mechanism not clear yet CC.The relative expressions RNAs were detected by real-time quantitative PCR (RT-qPCR). Colony formation assay, EdU stained assay CCK-8 to check cell proliferation ability CC. Flow cytometry apoptosis related...
Long noncoding RNAs (lncRNAs) play critical roles in the pathogenesis of various diseases, including a variety tumors. Nevertheless, its functional and underlying molecular basis for their dysregulation lung adenocarcinoma (LUAD) are largely unknown. Herein, our study, we identified that lncRNA TMPO-AS1 is significantly upregulated LUAD tissues cell lines. Knockdown remarkably suppressed growth, induced apoptosis as well G1/S arrest, inhibited invasion, whereas overexpression exerts opposite...
Pancreatic cancer (PC) represents one of the most aggressive forms cancer. The role long non-coding RNAs (lncRNAs) has been highlighted in various malignancies including PC. aim present study was to investigate effects associated with actin filament-associated protein 1 antisense RNA (AFAP1-AS1) on progression PC and underlying mechanism. Microarray-based gene expression profiling performed identify PC-related lncRNAs, after which AFAP1-AS1 stem cell (CSC) markers tissues cells were...
Osteoarthritis (OA) is a prevalent and debilitating joint disorder that affects millions of individuals worldwide, severely impairing mobility, independence, quality life. Emerging evidence suggests ferroptosis critical factor in OA pathogenesis. However, its precise involvement underlying mechanisms remain poorly understood. In this study, we first identified cartilage intermediate layer protein (CILP) mediates the regulation ferroptosis-related genes through hdWGCNA analysis combined with...
Objectives: The long-noncoding RNAs (lncRNAs) are identified as new crucial regulators of diverse cellular processes in glioblastoma (GBM) tissues. However, the expression pattern and biological function lncRNAs remain largely unknown. Here, for first time, effects lncRNA lymphoid enhancer-binding factor 1 antisense RNA ( LEF1-AS1 ) on GBM progression both vitro vivo investigated. Materials methods: Expression profiles specimens were investigated by bioinformatics analyses. tissues was...
Currently, cancer-related competing endogenous RNA (ceRNA) networks are attracting significant interest. As long noncoding ZEB1-AS1 has been reported to function as an oncogene due sponging microRNAs (miRNAs) in several cancers, we hypothesized that it could interact with specific miRNAs form regulatory and facilitate the growth of gastric cancer (GC). MiRNAs interacting were screened for selected by bioinformatics analysis. Overexpression or repression was performed determine whether...
Abstract Numerous studies have suggested that urothelial cancer‐associated 1 (UCA1) acts as a suppressor gene affecting cell proliferation and migration. However, the biological role potential mechanism of UCA1 in progression pre‐eclampsia (PE) remains unclear. The level was markedly upregulated PE pregnancies relative to non‐PE ones GSE75010 tissues. A higher body mass index (BMI), maximum systolic blood pressure (BP), diastolic BP were observed pregnancies, whereas newborn weight z ‐score...
8573 Background: Immunotherapy combined with chemotherapy has been established as the standard first-line treatment for patients advanced squamous NSCLC (sq-NSCLC) without oncogenic driver mutations. Antiangiogenic drugs enhance immunotherapy efficacy by normalizing blood vessels and remodeling tumor microenvironment. However, they pose a high bleeding risk in sq-NSCLC treatment. Recombinant human endostatin (Rh-endostatin), only approved agent sq-NSCLC, can prolong survival increasing risk....
Abstract Myocardial injury is a frequently occurring complication of sepsis. This study aims to investigate the molecular mechanism long noncoding RNA (lncRNA) small nucleolar host gene 1 (SNHG1)‐mediated DNA methyltransferase 1/B‐cell lymphoma‐2 (DNMT1/Bcl‐2) axis in sepsis‐induced myocardial injury. Mice and HL‐1 cells were treated with lipopolysaccharide (LPS) establish animal cellular models simulating sepsis inflammation. LncRNA SNHG1 was screened out as differentially expressed lncRNA...
Larynx cancer is one of the most common cancers in head and neck, imposes heavy burden on individual societies. A comprehensive understanding larynx necessary to improve prevention control strategies. However, secular trend incidence mortality China remains unclear.The deaths rates from 1990 2019 were collected Global Burden Disease Study database. The temporal was analyzed using a joinpoint regression model. age-period-cohort model used explore age, period, cohort effects predict future...
Evidence has revealed that long non-coding RNAs (lncRNAs) are involved in carcinogenesis and tumor progression. lncRNAs play an important role regulation of numerous cellular processes including cell proliferation, apoptosis, cycle, differentiation, motility. Several studies have demonstrated lncRNA EPIC1 governs growth, migration, invasion, drug resistance human malignancies. However, the its underlying molecular mechanisms glioma not been investigated. In this study, we determined function...
In recent years, the identification of long non-coding RNAs (lncRNAs) led to analysis their characteristics in cancer biology. However, expression lncRNAs and clinical significance remain unclear. present study, an investigation that may be involved regulation metastasis using microarray polymerase chain reaction analyses resulted MLLT4 antisense RNA 1 (MLLT4‑AS1) as a significantly downregulated lncRNA gastric tissue compared with normal adjacent (P=0.006). Furthermore, downregulation...
In recent years, a large number of studies have shown that differentially expressed lncRNAs in tumors are capable inducing tumorigenesis and promoting tumor development. However, the role LINC01210 OC still remains unclear.Relative levels KLF4 tissues containing GSE40595 dataset those collected our hospital were determined. Prognostic potential was evaluated by Kaplan-Meier method. Correlation between expression assessed Spearman correlation test. After silence A2780 HO8910 cells, changes...
Long non-coding RNAs (lncRNAs) are involved in developing hepatocellular carcinoma (HCC). The present study explored the role of lncRNA LINC01194, which is upregulated HCC tissues and might be a vital regulator progression. Levels microRNA (miR)-655-3p, SMAD family member 5 (SMAD5) were assessed using reverse transcription quantitative real-time polymerase chain reaction (RT-qPCR). bioactivity Huh-7 cells was cell counting kit-8 transwell assays flow cytometry. Western blotting conducted to...
Improving plant resistance to Verticillium wilt (VW), which causes massive losses in Gossypium hirsutum, is a global challenge. Crop needs efficiently allocate their limited energy resources balance growth and defense. However, few transcriptional regulators specifically response V. dahliae the underlying mechanism cotton has not been identified. In this study, we found that expression of majority R2R3-MYB significantly changed relative other MYB types by infection. Of which, novel TF...
Multiple studies have revealed that the long non-coding RNA RPPH1 (Ribonuclease P Component H1) is involved in disease progression of solid tumors and neurodegenerative diseases. We aimed to explore functions pathogenesis acute myeloid leukemia (AML) underlying molecular mechanisms. The expression was examined blood samples AML patients human cell lines including THP-1 HL-60. microRNAs (miRNAs) targets were predicted with online tools validated dual luciferase reporter assay. malignant...