A5100743756- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Circular RNAs in diseases
- Immune cells in cancer
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Diabetes Treatment and Management
- Peroxisome Proliferator-Activated Receptors
- RNA Research and Splicing
- Bariatric Surgery and Outcomes
- Mesenchymal stem cell research
- Inflammatory mediators and NSAID effects
- Neuroinflammation and Neurodegeneration Mechanisms
- Metabolism, Diabetes, and Cancer
- Histone Deacetylase Inhibitors Research
- Gastric Cancer Management and Outcomes
- Alzheimer's disease research and treatments
- Gastroesophageal reflux and treatments
- Nuclear Receptors and Signaling
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Zhejiang Provincial People's Hospital
2018-2024
Hangzhou Medical College
2018-2024
Qingdao Women and Children's Hospital
2023
Qingdao University
2023
Third Xiangya Hospital
2018-2021
Central South University
2006-2021
Harbin Medical University
2021
First Affiliated Hospital of Harbin Medical University
2021
Nanjing University of Chinese Medicine
2020
Some anti-diabetic drugs have been proved to be a tumor suppressor or activator. The associations of three relatively new classes medications-glucagon-like peptide-1 receptor agonists (GLP-1RA), dipeptidyl peptidase 4 inhibitors (DPP-4I), and sodium-glucose cotransporter 2 (SGLT-2I) with lung cancer prognosis remain unclear. electronic medical data from the National Healthcare Big Data (East) Center was retrospectively analyzed. We included 11,357 newly diagnosed patient type diabetes (T2D)...
Pancreatic cancer (PC) represents one of the most aggressive forms cancer. The role long non-coding RNAs (lncRNAs) has been highlighted in various malignancies including PC. aim present study was to investigate effects associated with actin filament-associated protein 1 antisense RNA (AFAP1-AS1) on progression PC and underlying mechanism. Microarray-based gene expression profiling performed identify PC-related lncRNAs, after which AFAP1-AS1 stem cell (CSC) markers tissues cells were...
MiRNAs may regulate neurogenic differentiation of adipose-derived stem cells (ADSCs). In this study, we hypothesized that the miR-142-5p can repress expression RhoA/ROCK1 pathway on neurogenesis ADSCs.Deregulated miRNA during ADSCs were identified. The neuron-specific enolase (NSE) and β III tubulin (Neuron-specific class beta-tubulin) detected as markers by immunostaining western blot. targeting RhoA ROCK1 was verified dual luciferase assay, qRT-PCR roles signaling explored using functional...
Background Gastroesophageal reflux disease (GERD) is among the most common complications of bariatric surgery. This study aimed to analyse risk factors affecting worsening GERD symptoms after laparoscopic sleeve gastrectomy (LSG), and establish validate a related nomogram model. Methods The recruited 236 participants randomly divided them into training validation sets in ratio 7:3. LASSO regression technique was used select optimal predictive features, multivariate logistic construct column...
Long non-coding RNAs (lncRNAs) have been reported to serve key roles in human cancer types, including glioma. However, the best of our knowledge, expression and function lncRNA LINC00210 glioma not previously investigated. The present study was conducted explore regulatory role cells. demonstrated that significantly upregulated tissues, high associated with advanced clinical stage poor prognosis patients It found knockdown inhibited proliferation migration U251 T98G results luciferase...
Abstract Although multiple factors are known to concur with Alzheimer’s disease (AD), the relationship between human cytomegalovirus (HCMV) and AD-like is unclear. Here, we propose a hypothesis that HCMV immediate-early 2 (IE2) protein promotes microglia activation thus leads disease. We successfully constructed IE2 transgenic mice expressing in hippocampus. Single-cell sequencing analysis revealed promoted of upregulated expression disease-associated genes. Differentially expressed gene...
Abstract Background: Long noncoding RNAs are widely studied in glioma. However, the role of lncRNA NEAT1 and KDM3A glioma has not yet been reported. We aimed to reveal these two lncRNAs development through this study. Methods: Samples from patients normal brain tissues were collected, expression was detected by qRT-PCR. A dual-luciferase reporter gene assay, chromatin immunoprecipitation (ChIP), RNA-binding protein (RIP), RNA pulldown experiments used identify relationship between FOXK1,...