A5080360119- Pharmacogenetics and Drug Metabolism
- Genomics, phytochemicals, and oxidative stress
- Drug-Induced Hepatotoxicity and Protection
- Eicosanoids and Hypertension Pharmacology
- Particle physics theoretical and experimental studies
- Renal cell carcinoma treatment
- High-Energy Particle Collisions Research
- Ion channel regulation and function
- Pharmacological Effects of Natural Compounds
- Gout, Hyperuricemia, Uric Acid
- Antimicrobial Peptides and Activities
- Phytochemicals and Antioxidant Activities
- Carcinogens and Genotoxicity Assessment
- Biochemical and Structural Characterization
- Drug Transport and Resistance Mechanisms
- Quantum Chromodynamics and Particle Interactions
- Gut microbiota and health
- Pediatric Urology and Nephrology Studies
- Natural product bioactivities and synthesis
- Ion Transport and Channel Regulation
- Renal and related cancers
- Natural Antidiabetic Agents Studies
- Carbohydrate Chemistry and Synthesis
- Glutathione Transferases and Polymorphisms
- Antibiotics Pharmacokinetics and Efficacy
Qingdao University
2011-2024
Southern Medical University
2008-2024
Sixth Affiliated Hospital of Sun Yat-sen University
2022-2024
Shenyang Pharmaceutical University
2007-2024
Sun Yat-sen University
2008-2024
Shenzhen Maternity and Child Healthcare Hospital
2024
Shanghai Chest Hospital
2024
Shanghai Jiao Tong University
2024
Liaoning Cancer Hospital & Institute
2023
China Medical University
2012-2023
We investigated an outbreak of severe fever with thrombocytopenia syndrome (SFTS) that occurred during May and June 2010, to identify the mode transmission. Contact index patient's blood was significantly associated development SFTS (P = .01, by χ(2) test for linear trend); frequency contact increased risk in a dose-response manner .03, trend). concluded human-to-human transmission caused this cluster cases.
TMEM16A Ca2+-activated Cl- channels are expressed in pancreatic acinar cells and participate inflammation-associated diseases. Whether contributes to the pathogenesis of acute pancreatitis (AP) remains unknown. Here, we found that increased expression tissue was correlated with interleukin-6 (IL-6) level serum a cerulein-induced AP mouse model. IL-6 treatment promoted AR42J via receptor (IL-6R)/signal transducers activators transcription 3 (STAT3) signaling pathway. In addition,...
Metabolic diseases are often associated with high fructose (HF) consumption. HF has also been found to alter the gut microbiota, which then favors development of nonalcoholic fatty liver disease. However, mechanisms underlying microbiota on this metabolic disturbance yet be determined. Thus, in study, we further explored effect concerning T cells balance an diet mouse model. We fed mice 60% fructose-enriched for 12 weeks. At 4 weeks, did not affect liver, but it caused injury intestine and...
The GDP dissociation inhibitors (GDIs) are pivotal regulators of Rho GTPases, which essential for tumor progression, particularly in the area metastasis. One member GDIs was identified as RhoGDI (Rho GDP-dissociation inhibitor alpha, or RhoGDIα), but little is known about this protein tumors. In study, we used comparative proteomic analysis to show that markedly up-regulated metastatic colorectal cancer (CRC). elevated level CRC confirmed by Western blot at tissue (n = 24) and cell 6)...
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a novel phlebovirus that was identified to be the etiological pathogen of emerging infectious disease, severe (SFTS). SFTSV could transmitted through tick bite. Transmission among humans has also been reported mainly direct blood contact. In July 2014, cluster six suspected SFTS cases occurred in Shandong Province, China. this cluster, both symptomatic and asymptomatic persons were included. By analyzing clinical data results...
Refractory/relapsed B cell lymphoma patients who received the available anti-CD19 chimeric antigen receptor (CAR) T cells may still experience a short duration of remission. Here in this study, we evaluated safety and efficacy novel dominant-negative programmed death-1 (PD-1) armored CAR cells. A total 9 (including 4 diffuse large lymphomas, DLBCL, 2 transformed follicular TFL, 3 FL) infusion at dose more than 1 × 106/kg. Grade ≥ cytokine release syndrome (CRS) neurotoxicity were observed...
In the course of our research on utilizing edible flower resources to promote health, five ellagitannins (1–5) were isolated from pomegranate (Punica granatum L.) by bioassay-guided fractionation. Among them, mallotusinin (1) and tercatain (2) first flower, punicatannin D (4) was an unprecedented compound. Compounds 1–3 exhibited significant xanthine oxidase (XO) inhibitory activity compared with allopurinol, a potent inhibition α-glucosidase that superior acarbose observed for compounds...
The non disulphide-bridged peptides (NDBPs) of scorpion venoms are attracting increased interest due to their structural heterogeneity and broad spectrum biological activities.Here, two novel peptides, named AcrAP1 AcrAP2, have been identified in the lyophilised venom Arabian scorpion, Androctonus crassicauda, through "shotgun" molecular cloning biosynthetic precursor-encoding cDNAs.The respective mature predicted from these cloned cDNAs, were subsequently isolated same sample using reverse...
Benzbromarone (BBR) is effective in the treatment of gout; however, clinical findings have shown it can also cause fatal hepatic failure. Our early studies demonstrated that CYP3A catalyzed biotransformation BBR to epoxide intermediate(s) reacted with sulfur nucleophiles protein form covalent binding both vitro and vivo. The present study attempted define correlation between metabolic epoxidation hepatotoxicity by manipulating structure BBR. We rationally designed synthesized three...
To comprehensively assess the safety of Lifitegrast, a drug for dry eye disease, we conducted comprehensive analysis adverse event (AE) reports from FDA Adverse Event Reporting System (FAERS). This retrospective study examined all AE submitted between Q3 2016 and Q2 2024, employing disproportionality to identify signals associated with Lifitegrast. Out total 13,326,934 indexed in FAERS database, 12,393 listed Lifitegrast as primary suspect drug. A 230 ocular were identified, 104 these AEs...
To explore the interactions between smoking and CYP2A6 genotypes on type 2 diabetes (T2DM) as well potential pathways for in causing T2DM.Cross-sectional study.A total of 1344 smokers with complete data from a community-based T2DM survey Guangzhou Zhuhai China July 2006 to June 2007 were interviewed structured questionnaire about socio-demographic status daily cigarette consumption. Serum glucose, insulin, cotinine measured after an overnight fast. Subjects genotyped classified, according...
ABSTRACT Huo Luo Xiao Ling Dan (HLXLD), a Chinese herbal formula composed of 11 different herbs, has been used traditionally for the treatment arthritis and other chronic inflammatory diseases. However, pharmacokinetic profile its anti‐inflammatory bioactive compounds not elucidated. Boswellic acids are with potent activity isolated from Boswellia serrate which is one herbs HLXLD. The objective study was to compare pharmacokinetics two bowsellic acids: 11‐keto‐ β ‐boswellic acid 3‐ O...
The calcium-activated chloride channel Ano1 (TMEM16A) is overexpressed in many tumors. However, conflicting data exist regarding the role of cell proliferation. Here, we performed immunohistochemistry to investigate expression and Ki67 403 patients with breast cancer, analyzed association between cancer subtypes categorized according estrogen receptor (ER), progesterone (PR), human epidermal growth factor 2 (HER2). was negatively correlated expression. overexpression more frequently occurred...
Benzbromarone (BBR) is a therapeutically useful uricosuric agent but can also cause acute liver injury. The hepatotoxicity of BBR suggested to be associated with its metabolic activation. Our recent study demonstrated that was metabolized epoxide intermediate(s) by cytochrome P450 3A, and the reactive N-acetylcysteine. objectives present were determine chemical identity interaction protein define association modification induced BBR. Microsomal incubation showed covalently modified...
Ca2+ -activated Cl- channels (Ano1 channels) contribute to the pathogenesis of colorectal cancer. Honokiol is known inhibit cell proliferation and tumour growth in However, molecular target honokiol remains unclear. This study aimed investigate whether inhibited cancer by targeting Ano1 channels.Patch-clamp techniques were performed effect on currents HEK293 cells overexpressing Ano1- or Ano2-containing plasmids human carcinoma SW620 cells. Site-directed mutagenesis was used identify...
Lathyrol is a core scaffold structure of many lathyrane diterpenoids with potent anti-inflammatory activity isolated from Euphorbia lathyrism. It was chosen as framework to design and synthesize series proteolysis targeting chimeras. A total 15 derivatives were obtained. Compound 13 exhibited inhibitory on LPS-induced NO production in RAW264.7 cells (IC50 = 5.30 ± 1.23 μM) low cytotoxicity. Furthermore, compound significantly degraded v-maf musculoaponeurotic fibrosarcoma oncogene homologue...
Abstract Non‐invasive transcranial direct‐current stimulation (tDCS) is a safe ischaemic stroke therapy. Cathodal bilateral tDCS (BtDCS) modified approach established by us recently. Because selenium (Se) plays crucial role in cerebral injury, we investigated whether cathodal BtDCS conferred neuroprotection via regulating Se‐dependent signalling rat ischaemia–reperfusion (I/R) injury. We first showed that the levels of Se and its transport protein selenoprotein P (SEPP1) were reduced...
Variations in the activities of Cytochrome P450s are one major factors responsible for inter-individual differences drug clearance rates, which may cause serious toxicity or inefficacy therapeutic drugs. Various mRNA level is key different activity P450 genes. Although both genetic and environmental regulators gene expression have been widely investigated, few studies evaluated functional importance cis- trans-regulatory modulation variations In this study, we measured levels seven genes...
PTEN-Long is a translational variant of PTEN (Phosphatase and Tensin Homolog). Like PTEN, able to antagonize the PI3K-Akt pathway inhibits tumor growth. In this study, we investigated role plays in development progression clear cell renal carcinoma (ccRCC) explored therapeutic possibility using proteinaceous treat ccRCC. We found that protein levels were drastically reduced ccRCC, which was correlated with increased phosphorylated Akt (pAkt). Gain function experiments showed overexpression...