A5031797565- Viral Infections and Vectors
- Mosquito-borne diseases and control
- Vector-Borne Animal Diseases
- Vector-borne infectious diseases
- Fire effects on ecosystems
- Viral Infections and Outbreaks Research
- Monoclonal and Polyclonal Antibodies Research
- Health, Environment, Cognitive Aging
- Rheumatoid Arthritis Research and Therapies
- Immunodeficiency and Autoimmune Disorders
- Insect Resistance and Genetics
- Toxin Mechanisms and Immunotoxins
- Malaria Research and Control
- Virology and Viral Diseases
- Systemic Lupus Erythematosus Research
- Insect-Plant Interactions and Control
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Birth, Development, and Health
- Epigenetics and DNA Methylation
- HIV Research and Treatment
- Insect symbiosis and bacterial influences
- Entomopathogenic Microorganisms in Pest Control
- Plant Virus Research Studies
- SARS-CoV-2 and COVID-19 Research
Wuhan Institute of Virology
2016-2024
Chinese Academy of Sciences
2016-2024
University of Chinese Academy of Sciences
2024
Huazhong University of Science and Technology
2023
Berkeley Public Health Division
2023
University of California, Berkeley
2023
Loyola University Medical Center
2013-2014
Leiden University Medical Center
2013
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a novel phlebovirus that was identified to be the etiological pathogen of emerging infectious disease, severe (SFTS). SFTSV could transmitted through tick bite. Transmission among humans has also been reported mainly direct blood contact. In July 2014, cluster six suspected SFTS cases occurred in Shandong Province, China. this cluster, both symptomatic and asymptomatic persons were included. By analyzing clinical data results...
Abstract Jingmenviruses are a category of emerging segmented viruses that have garnered global attention in recent years, and close relatives the flaviviruses Flaviviridae family. One their genome segments encodes NSP1 homologous to flavivirus NS5. comprises both methyltransferase (MTase) RNA-dependent RNA polymerase (RdRP) modules playing essential roles viral replication capping. Here we solved 1.8-Å resolution crystal structure RdRP module from Jingmen tick virus (JMTV), type species...
Severe fever with thrombocytopenia syndrome (SFTS) is caused by severe virus (SFTSV), which has had a serious impact on public health in parts of Asia. There no specific antiviral drug or vaccine for SFTSV and, therefore, it important to determine the factors that influence occurrence infections. This study aimed explore spatial associations between infections and several potential determinants, predict high-risk areas mainland China. The analysis was carried out at level provinces...
Household air pollution (HAP) from indoor combustion of solid fuel is a global health burden linked to lung cancer. In Xuanwei, China, cancer rate for nonsmoking women among the highest in world and largely attributed high levels polycyclic aromatic hydrocarbons (PAHs) that are produced smoky (bituminous) coal used cooking heating. Epigenetic age acceleration (EAA), DNA methylation-based biomarker aging, has been shown be highly correlated with biological processes underlying susceptibility...
Honey bees are essential to the functioning of terrestrial ecosystems. However, despite no single factor being blamed for losses honey bee colonies in Europe and USA, viruses have been considered as a major driver. Moreover, virus vector can enhance titer virulence such Varroa destructor change deformed wing virus. Here, we report molecular evidence aphid lethal paralysis (ALPV) infecting Vespa velutina, which is an important predator bees, especially Apis cerana. Viral replication...
Severe fever with thrombocytopenia syndrome (SFTS), caused by SFTS virus (SFTSV) infection, was first reported in 2010 China an initial fatality of up to 30%. The laboratory confirmation SFTSV infection terms detection viral RNA or antibody levels is critical for diagnosis and therapy. In this study, a new luciferase immunoprecipitation system (LIPS) assay based on pREN2 plasmid expressing NP gene tagged Renilla (Rluc), established used investigate the responses SFTSV. Totally 464 serum...
Objective: Suckling mouse inoculation is an important method that has been used for years to isolate viruses from ticks; however, this usually briefly described in the literature on a case-by-case basis upon successful isolation rather than providing extensive details. Methods: This study describes procedure preparation of tick homogenates identification virus using suckling method. The transient and persistent features were characterized incidence manifestations developed mice, especially...
To increase the imaging resolution and detection capability, field strength of static magnetic fields (SMFs) in resonance (MRI) has significantly increased past few decades. However, research on side effects high is still very inadequate SMF above 1 T (Tesla) B cells have never been reported. Here, we show that 33.0 ultra-high exposure causes immunosuppression disrupts cell differentiation signaling. treatment resulted disturbance peripheral antibody secretion reduced expression IgM...
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by the tick-borne SFTS bunyavirus (SFTSV) resulting in a high fatality rate up to 30%. SFTSV negative-strand RNA virus containing three single-stranded genome segments designated as L, M, and S, which respectively, encode RNA-dependent polymerase (RdRp), glycoproteins Gn Gc, nucleoprotein (N) non-structural proteins (NSs). NSs can form inclusion bodies (IBs) infected transfected cells. A previous...
The transfection of plasmids into cell lines for the transient expression exogenous proteins is a fundamental method characterizing their functions, cellular localization and interactions. Currently, only few reports on tick systems specifically constructed have been published. In this study, transcriptome line IDE8 was analyzed to screen highly-expressed genes. upstream sequences these genes were selected as possible tick-derived promoters, promoter activity evaluated using luciferase...
Tick-borne encephalitis virus (TBEV) is a pathogen that causes febrile infectious diseases and neurological damage to humans. TBEVs are prevalent from Europe Far Eastern Asia, including Northeastern China. The understanding of TBEV phylogeny in China has been limited owing insufficient genomic data on Chinese strains. Here, six strains were isolated ticks collected Inner Mongolia. transmission electron microscopy revealed spherical particles with an enveloped structure 50-60 nm diameter....
<h3>Background</h3> Anti-citrullinated protein antibodies (ACPA) and IgM-Rheumatoid Factor (IgM-RF) are auto-antibodies that can be detected many years before the clinical diagnosis of Rheumatoid Arthritis (RA) [1]. Since ACPA IgM-RF known as predictive prognostic markers RA, it is conceivable these play a pathogenic role in RA. In recent studies we discovered anti-carbamylated (anti-CarP) marker RA [2]. addition anti-CarP associated with conversion to patients suffer from arthralgia [3]....
<h3>Background</h3> Anti-citrullinated protein antibodies (ACPA) have a low prevalence in Juvenile Idiopathic Arthritis (JIA). Autoantibodies recognizing carbamylated (anti-CarP) are promising new serological marker for ACPA negative Rheumatoid and associated with more severe clinical course (Shi et al, 2011). <h3>Objectives</h3> To determine the presence of anti-CarP sera JIA patients to investigate their prognostic value. <h3>Methods</h3> Samples 249 all subgroups JIA, taken at different...
<h3>Background</h3> Anti-citrullinated protein antibodies (ACPA) and IgM-Rheumatoid Factor (IgM-RF) are auto-antibodies that can be detected many years before the clinical diagnosis of Rheumatoid Arthritis (RA) [1]. Since ACPA IgM-RF known as predictive prognostic markers RA, it is conceivable these play a pathogenic role in RA. In recent studies we discovered anti-carbamylated (anti-CarP) marker RA [2]. addition anti-CarP associated with conversion to patients suffer from arthralgia [3]....
Household air pollution (HAP) from indoor combustion of solid fuel is a global health burden linked to lung cancer. The toxicity HAP largely attributed polycyclic aromatic hydrocarbons (PAHs), byproduct smoky (bituminous) coal used for cooking and heating. Epigenetic age acceleration (EAA), DNA methylation-based biomarker aging, has been shown be highly correlated with biological processes underlying the susceptibility age-related diseases. We aim assess association between exposure EAA....