A5048548823- Viral Infections and Vectors
- Vector-Borne Animal Diseases
- Mosquito-borne diseases and control
- Fire effects on ecosystems
- Vector-borne infectious diseases
- Viral Infections and Outbreaks Research
- Cryospheric studies and observations
- Animal Virus Infections Studies
- Bacteriophages and microbial interactions
- Plant and Fungal Interactions Research
- Animal Ecology and Behavior Studies
- Yersinia bacterium, plague, ectoparasites research
- vaccines and immunoinformatics approaches
- Plant Virus Research Studies
- Insect symbiosis and bacterial influences
- Aquaculture disease management and microbiota
- Zoonotic diseases and public health
- Parvovirus B19 Infection Studies
- Viral gastroenteritis research and epidemiology
- Respiratory viral infections research
People's Hospital of Xinjiang Uygur Autonomous Region
2025
Chinese Academy of Sciences
2019-2024
Wuhan Institute of Virology
2019-2024
Xinjiang Uygur Autonomous Region Disease Prevention and Control Center
2021-2024
Xinjiang University
2017-2021
Duke-NUS Medical School
2021
Tick-borne viral diseases have attracted much attention in recent years because of their increasing incidence and threat to human health. Severe fever with thrombocytopenia syndrome phlebovirus (SFTSV) Heartland virus (HRTV) were recently identified as tick-borne phleboviruses (TBPVs) Asia the United States, respectively, are associated severe similar clinical manifestations. In this study, we report first identification isolation a novel TBPV named Guertu (GTV) from Dermacentor nuttalli...
Abstract Background The great gerbil ( Rhombomys opimus ), whose ectoparasitic fleas significantly influence the transmission and prevalence of plague, was dominant rodent species in Junggar Basin Northwestern China. However, distribution pattern parasitizing gerbils whether that affected intensity plague different regions remains unclear. Methods A total 17,780 were collected from 2258 throughout 90 investigations. This study focused on analyzing rate flea infestation indices parasitized...
Introduction: This study compared the pattern of viral diarrhoea in Yichang City, China 2022 and 2023, before after lifting COVID-19 restrictions. Methods: Stool samples were collected from outpatients inpatients with at three hospitals January to October June restrictions, respectively. Samples simultaneously tested for 13 types enteric virus using a rapid multiplex assay that could detect five viruses, including rotavirus (groups A, B, C H), norovirus (I, II, IV, VII, VIII, IX),...
The Xinjiang Uygur Autonomous Region locating in Northwest of China was not considered the epidemic area severe fever with thrombocytopenia syndrome (SFTS). Here we report first laboratory-confirmed SFTS case that a female patient had tick bite and illness onset after returning to Hainan Province. Laboratory tests identified virus (SFTSV) infection, isolated from patient's serum sample. Furthermore, SFTSV prevalence among groups identified, IgM response febrile patients identified. findings...
We report the isolation of Tamdy virus from Hyalomma asiaticum ticks in northwest China and serologic evidence human infection same region. These findings highlight need to further investigate a potential causal relationship between febrile illnesses unknown etiology that
Haemaphysalis longicornis ticks, commonly found in East Asia, can transmit various pathogenic viruses, including the severe fever with thrombocytopenia syndrome virus (SFTSV) that has caused febrile diseases among humans Hubei Province. However, understanding of viromes H. was limited, and prevalence viruses ticks not well clarified. This study investigates both engorged (fed) free (unfed) across three mountainous regions Province from 2019 to 2020. RNA-sequencing analysis identified viral...
Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne pathogen that causes severe disease in humans. CCHFV widely distributed more than 30 countries and distinct regions, which means it poses serious threat to human health. The nucleocapsid protein (NP) encoded by the S gene primary detectable antigen infected cells, makes an important viral clinical diagnostic target. In this study, modified biosynthetic peptide (BSP) method was used identify fine epitopes on N- C- terminals of NP...
Permafrost serves as a natural cold reservoir for viral communities. However, little is known about the viromes in deep permafrost soil, most studies of were restricted to shallow areas. Here, soil samples up 100 m depth collected from two sites Tuotuo River area on Tibetan Plateau. We investigated composition these and analyzed relationship diversity along with depths. Our study revealed that greater thickness corresponds higher within community. Bacteriophages found be dominant...
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a novel tick-borne viral pathogen that causes severe (SFTS). The disease was initially reported in central and eastern China, then later Japan South Korea, mortality rate of 13-30%. Currently, no vaccines or effective therapeutics are available for SFTS treatment. In this study, three monoclonal antibodies (mAbs) targeting the SFTSV envelope glycoprotein Gn were obtained using hybridoma technique. Two mAbs recognized linear...
Despite few human cases of tick-borne encephalitis virus (TBEV), high rates TBEV seroprevalence were reported among humans and animals in Xinjiang Uygur Autonomous Region Northwestern China. In this study, the Karshi (KSIV) was identified isolated from Hyalomma asiaticum ticks Xinjiang. It belongs to genus Flavivirus family Flaviviridae is closely related TBEV. KSIV infects cell lines humans, other mammals ticks, causes suckling mice. High minimum infection (4.96%) with detected tick groups....
Background: Ticks are a major arthropod vector of zoonotic diseases affecting both humans and domestic animals worldwide. Thus, studying tick microbiota would aid in understanding the potential threats posed by ticks. Methods: Approximately 8,000 unfed ticks, identified as Dermacentor nuttalli , were collected from sylvosteppe western Tianshan mountains. To investigate their pathogens, we divided ticks into 36 groups 200–300 individuals each for examination with culturomics 16S rDNA amplicon...
Tick-borne viral diseases have become an increasingly important public health concern. Tamdy virus (TAMV) is a tick-borne of the genus Orthonairovirus in family Nairoviridae. While some studies suggested that TAMV pathogen associated with human febrile illness, its epidemiology and risk spill-over remain poorly understood.Ticks were collected Xinjiang, China, grouped into pools. RT-PCR assays used to detect RNA these The seroprevalence was investigated using Immunofluorescence assays,...
Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV) was recently identified as a tick-borne pathogen that threat to human health. Since 2010, many countries including China, South Korea, and Japan have reported Human SFTS caused by SFTSV infection. The glycoprotein encoded the M gene is major antigenic component on viral surface, responsible for entry, which makes it an important antigen clinical diagnostic target. present study aimed map linear B cell epitopes (BCEs) N-terminal (Gn)...
Guertu virus (GTV) is a tick-borne phleboviruses (TBPVs) which belongs to the genus Banyangvirus in family of Phenuiviridae. In vitro and vivo studies GTV demonstrated that it was able infect animal human cell lines could cause pathological lesions mice. Glycoproteins (GP, including Gn Gc) on surface bind receptors host cells induce protective immunity host, but knowledge now lacking information B epitopes (BCEs) present GTV-GP protein. The aim this study identify all BCEs DXM strain using...
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Tick-borne encephalitis virus (TBEV) is a pathogen that causes febrile infectious diseases and neurological damage to humans. TBEVs are prevalent from Europe Far Eastern Asia, including Northeastern China. The understanding of TBEV phylogeny in China has been limited owing insufficient genomic data on Chinese strains. Here, six strains were isolated ticks collected Inner Mongolia. transmission electron microscopy revealed spherical particles with an enveloped structure 50-60 nm diameter....
<title>Abstract</title> Background The great gerbil (<italic>Rhombomys opimus</italic>), its ectoparasitic fleas significantly influence the transmission and prevalence of plague, was dominant rodent specie in Junggar Basin northwestern China. However, distribution pattern parasitizing gerbils whether that affected intensity plague different regions remain unclear. Methods A total 17,780 were collected from 2,258 through 90 investigations. This study focused on analyzing rate flea...
Objective: This study was aimed at investigating the viral diversity associated with marine organisms in South China Sea, to improve understanding of region’s ecosystems. Viruses profoundly influence aquatic ecosystems, by affecting biogeochemical cycles and posing threats organisms. Nonetheless, a comprehensive organisms’ Sea remains lacking. Methods: We collected gill viscera tissue samples from three phyla ( Chordata , Arthropoda Mollusca ) along coast. High-throughput sequencing...
Abstract Crimean-Congo Hemorrhagic Fever (CCHF), caused by the CCHF virus (CCHFV), is a severe tick borne zoonosis widely distributed in over 30 countries and regions. Currently, there no licensed vaccine available for China. To evaluate cellular humoral immune responses induced multi-epitope DNA protein of BALB/c mice, gene (MEPX) segment with tandem including six highly conservative immunedominant B cell epitopes was designed based on analysis hydrophilicity antigenic determinant sites...