A5100771912- Vitamin K Research Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Wheat and Barley Genetics and Pathology
- Viral Infections and Vectors
- Neuroinflammation and Neurodegeneration Mechanisms
- Viral Infections and Outbreaks Research
- Hematopoietic Stem Cell Transplantation
- Aquaculture disease management and microbiota
- Protein Kinase Regulation and GTPase Signaling
- Complement system in diseases
- Crop Yield and Soil Fertility
- Climate Change and Health Impacts
- Psychosocial Factors Impacting Youth
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- Marine Bivalve and Aquaculture Studies
- GABA and Rice Research
- Phytase and its Applications
- Heme Oxygenase-1 and Carbon Monoxide
- Effects of Radiation Exposure
- Chemical synthesis and alkaloids
- Enzyme function and inhibition
- Air Quality and Health Impacts
- Genomics, phytochemicals, and oxidative stress
- Vector-Borne Animal Diseases
Second Hospital of Shanxi Medical University
2011-2024
Shanxi Medical University
2011-2024
Hubei University of Medicine
2024
Taihe Hospital
2024
University of Missouri
2015-2023
South China Agricultural University
2017-2023
Anhui Medical University
2022
Henan Academy of Agricultural Sciences
2009-2022
Ministry of Education of the People's Republic of China
2022
Beihua University
2021
The multikinase inhibitor sorafenib is the first oral agent to show activity against human hepatocellular carcinoma (HCC). Apoptosis has been shown be induced in HCC by several agents, including as well naturally occurring K vitamins (VKs). As few nontoxic agents have growth, we evaluated of and VKs, both independently together on growth cells vitro vivo. We found that when VK was combined with sorafenib, concentration required for inhibition substantially reduced. Conversely, enhanced...
A characteristic defect occurs in rat and human hepatocellular carcinoma (HCC) resulting a loss of function the vitamin K-dependent enzyme gamma-glutamyl-carboxylase tumor but not underlying liver. This causes secretion elevated levels immature or des-gamma-carboxylated form prothrombin, which is used as marker HCC. We investigated whether, using defined conditions growing HCC cell lines tissue culture, addition naturally occurring vitamins K1 K2 synthetic K3 could influence prothrombin....
Apoptosis has been shown to be induced by many agents, including the clinically useful Sorafenib and K vitamins (VKs). Since few agents have activity against pancreas cancer cell growth, we evaluated role of naturally occurring both independently together on growth in culture adenocarcinoma lines, PL-5, PANC-1, MIA PaCa-2. We found that when a vitamin was combined with Sorafenib, dose required for inhibition substantially reduced. Furthermore, could inhibited at doses each VK plus...
Using two distinct myeloperoxidase (MPO) inhibitors, we show for the first time that MPO plays an important role in producing increases free 2-chlorofatty aldehyde (2-ClFALD)—a powerful proinflammatory chlorinated lipid plasma and intestine—a number of cytokines other inflammatory mediators, leukocyte platelet rolling adhesion postcapillary venules, lung injury a cecal ligation puncture model sepsis. In addition, use plasminogen activator inhibitor-1 (PAI-1) inhibitor or mast cell stabilizer...
Critical limb ischemia (CLI) is a severe complication of diabetes mellitus that occurs without effective therapy. Excessive reactive oxygen species (ROS) production and oxidative stress play critical roles in the development diabetic cardiovascular complications. N-acetylcysteine (NAC) reduces ischemia-induced ROS production. The present study aimed to investigate effect NAC on recovery ischemic an experimental model type-2 diabetes. TALLYHO/JngJ SWR/J non-diabetic mice were used for...
Please cite this paper as: Wang, Kalogeris, Jones and Korthuis (2010). Antecedent Ethanol Attenuates Cerebral Ischemia/Reperfusion-Induced Leukocyte-Endothelial Adhesive Interactions Delayed Neuronal Death: Role of Large Conductance, Ca2+-activated K+ Channels. Microcirculation17(6), 427–438. EtOH-PC reduces postischemic neuronal injury in response to cerebral (I/R). We examined the mechanism underlying protective effect by determining (i) whether it was associated with a decrease...
Interleukin 1beta (IL-1beta) and nitric oxide (NO) have potent growth-regulatory effects on different cell types. We found that epidermal growth factor-induced DNA synthesis in primary cultures of adult rat hepatocytes was inhibited by NO when it provided addition to the S-nitroso-N-acetyl-penicillamine (SNAP), an donor, as well IL-1beta a dose-dependent manner. also induced production inducible synthase (iNOS) gene expression. The inhibition completely abrogated N-monomethyl-L-arginine...
ABSTRACT Increased endothelial cell adhesion molecule (ECAM) expression, leukocyte-endothelial adhesive interactions (LECA), platelet-endothelial (PECA), mast activation, production of reactive oxygen species (ROS), and microvascular permeability are hallmarks the inflammatory response. The infiltration phagocytes is associated with myeloperoxidase (MPO)-dependent hypochlorous acid, a chlorinating that targets membrane lipids to produce halogenated such as 2-chlorohexadecanal (2-ClHDA)...
Males have a higher risk for cardiovascular diseases (CVDs) than females. Ambient fine particulate matter (PM) exposure increases CVD with increased reactive oxygen species (ROS) production and oxidative stress. Endothelial progenitor cells (EPCs) are important to vascular structure function can contribute the development of CVDs. The aims present study were determine if sex differences exist in effect PM on circulating EPCs mice and, so, whether stress plays role. Male female C57BL/6 (8–10...
Intestinal injury is the primary toxicity of radiotherapy for pelvic and abdominal tumors, it also one common acute complications radiotherapy. At present, there are no effective drugs to prevent intestinal in clinic. Zingerone a natural product with radioprotective effects. In this study, novel compound (thiazolidine hydrochloride, TZC01) was synthesized by structural modification zingerone. The effects TZC01 on preventing from radiation were further investigated study. C57BL/6N mice...
Allograft rejection after renal transplantation remains a challenge to overcome. Interleukin (IL)-21, cytokine with pleiotropic effects, maintains immune homeostasis post-transplantation. Here, we report higher levels of IL-21 in kidney transplant recipients non-rejection (NR) than T cell-mediated (TCMR, P < 0.001) and antibody-mediated (ABMR, = 0.005). We observed negative correlation between creatinine (Cr) (P 0.016). The receiving operating characteristic (ROC) curve showed promising...
Abstract The hematopoietic system is sensitive to radiation. In this research, new aryl sulfone derivatives (XH-201 and XH-202) containing a nitrogen heterocycle were designed synthesized their radio-protective efficacies with regard the evaluated. XH-201 administration significantly increased survival rate of mice after 8.0 Gy total body irradiation (TBI). results showed that treatment not only white blood cells, platelets counts percentage progenitor cells stem in exposed 4.0 TBI but also...
Hepatitis is a complex multifactorial pathological disorder, which can eventually lead to liver failure and even potentially be life threatening. Paeoniflorin-6′-O-benzene sulfonate (CP-25) has proven have critical anti-inflammatory effects in arthritis. However, the of CP-25 pathogenesis hepatitis remains unclear. In this experiment, mice were intragastrically administered with (25, 50 100 mg/kg), then ConA (25 mg/kg) was intravenous injected establish model vivo . administration attenuated...
2,4,* 1 河南省农业科学院小麦研究所, 河南郑州 450002; 2 中国农业科学院作物科学研究所 / 国家小麦改良中心, 北京 100081; 3 云南省 农业科学院粮食作物研究所, 云南昆明 650205; 4 国际玉米小麦改良中心(CIMMYT)中国办事处, 100081 摘 要: 高分子量麦谷蛋白亚基(HMW-GS
Gonococcal conjunctivitis is due to ophthalmic infection with Neisseria gonorrhoeae, and it considered rare in the non-neonatal populations, particularly its association gonorrhea chlamydial urethritis same patient. Here we describe a 27-year-old newly married man presenting gonococcal discuss selection of antibiotic drugs associated course.