A5046199578- Advanced Sensor and Energy Harvesting Materials
- Fiber-reinforced polymer composites
- Membrane Separation Technologies
- Solar-Powered Water Purification Methods
- Mechanical Behavior of Composites
- Conducting polymers and applications
- Electrospun Nanofibers in Biomedical Applications
- Nanoplatforms for cancer theranostics
- Supercapacitor Materials and Fabrication
- Silk-based biomaterials and applications
- Surface Modification and Superhydrophobicity
- Advancements in Battery Materials
- Phase Change Materials Research
- Recycling and Waste Management Techniques
- Advanced Battery Materials and Technologies
- Textile materials and evaluations
- Graphene research and applications
- Cancer Research and Treatments
- Bone Tissue Engineering Materials
- Polymer composites and self-healing
- Immunotherapy and Immune Responses
- Extraction and Separation Processes
- Thermal Radiation and Cooling Technologies
- Particle accelerators and beam dynamics
- Cellular and Composite Structures
Shinshu University
2011-2025
Ōtani University
2011-2025
Nantong University
2007-2025
National Center for Nanoscience and Technology
2015-2024
Fuyang Normal University
2022-2024
Second People’s Hospital of Yibin
2024
Wuhan YZY Biopharma (China)
2022-2023
South China Agricultural University
2019-2023
Key Laboratory of Guangdong Province
2023
University of Nottingham Ningbo China
2023
Near-infrared plasmonic nanoparticles demonstrate great potential in disease theranostic applications. Herein a nanoplatform, composed of mesoporous silica-coated gold nanorods (AuNRs), is tailor-designed to optimize the photodynamic therapy (PDT) for tumor based on effect. The surface plasmon resonance AuNRs was fine-tuned overlap with exciton absorption indocyanine green (ICG), near-infrared dye poor photostability and low quantum yield. Such greatly increases singlet oxygen yield...
Natural, extracellular membrane vesicles secreted by Gram-negative bacteria, outer (OMVs), contain numerous pathogen-associated molecular patterns which can activate systemic immune responses. Previous studies have shown that OMVs induce strong IFN-γ- and T cell-mediated anti-tumor effects in mice. However, IFN-γ is known to upregulate immunosuppressive factors the tumor microenvironment, especially checkpoint programmed death 1 ligand (PD-L1), may hamper cell function limit...
Biomimetic camouflage, i.e., using natural cell membranes for drug delivery, has demonstrated advantages over synthetic materials in both pharmacokinetics and biocompatibility, so represents a promising solution the development of safe nanomedicine. However, only limited efforts have been dedicated to engineering such camouflage endow it with optimized or additional properties, particular properties critical "smart" delivery system, as stimuli-responsive release. A pH-responsive biomimetic...
Abstract A novel cleavable amphiphilic peptide (CAP) was designed to be specifically responsive fibroblast activation protein‐α (FAP‐α), a protease expressed on the surface of cancer‐associated fibroblasts. The CAP self‐assembled into fiber‐like nanostructures in solution, while presence hydrophobic chemotherapeutic drugs readily transformed assemblies drug‐loaded spherical nanoparticles. disassembly these nanoparticles (CAP‐NPs) upon FAP‐α cleavage resulted rapid and efficient release...
Cancer vaccines based on resected tumors from patients have gained great interest as an individualized cancer treatment strategy. However, eliciting a robust therapeutic effect with personalized remains challenge because of the weak immunogenicity autologous tumor antigens. Utilizing exogenous prokaryotic constituents that act adjuvants to enhance is promising strategy overcome this limitation. nonspecific stimulation immune system may elicit undesirable immunopathological state. To...
Hydrogels that combine the integrated attributes of being adhesive, self-healable, deformable, and conductive show great promise for next-generation soft robotic/energy/electronic applications. Herein, we reported a dual-network polyacrylamide (PAAM)/poly(acrylic acid) (PAA)/graphene (GR)/poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) (MAGP) hydrogel composed dual-cross-linked PAAM PAA as well PEDOT:PSS GR conducting component combines these features. A wearable strain...
Advanced textiles designed for personal thermal management contribute to thermoregulation in an individual and energy-saving manner. Textiles incorporated with phase changing materials (PCMs) are capable of bridging the supply demand energy by absorbing releasing latent heat. The integration solar heating Joule function supplies multidriving resources, facilitates charging storage, expands service time application scenarios. Herein, we report a fibrous membrane-based textile that was...
Recently, therapeutic antibodies against programmed cell death 1 (PD-1) and its ligand (PD-L1) have exerted potent anticancer effect in a variety of tumors. However, blocking the PD-1/PD-L1 axis alone is not sufficient to restore normal immune response. Other negative regulators antitumor immunity, like TGF-β VEGFA, are also involved escape tumor cells induce immunotherapy resistance.We developed novel anti-TGF-β/VEGF bispecific antibody Y332D based on Nano-YBODY™ technology platform. The...
Osteoarthritis (OA) is a chronic joint disease characterized by progressive degeneration of articular cartilage. A challenge in the development disease-modifying drugs effective delivery to chondrocytes. The unique structure promotes rapid clearance through synovial fluid, and dense avascular cartilage extracellular matrix (ECM) limits drug penetration. Here, we show that poly(lactide- co -glycolic acid) nanoparticles coated chondrocyte membranes (CM-NPs) were preferentially taken up rat...
An integrated cell-penetrating peptide-assembly-based nanomaterial is engineered as a dual-mode strategy for enhancing nanotherapeutic tumor targeting and penetration through recognition depletion of cancer-associated fibroblasts. The composed fibroblast-specific antibody overcoming tissue barrier cell-penetration peptide-mediated enhanced cellular uptake. As service to our authors readers, this journal provides supporting information supplied by the authors. Such materials are peer...
Abstract A cytocompatible porous scaffold mimicking the properties of extracellular matrices (ECMs) has great potential in promoting cellular attachment and proliferation for tissue regeneration. biomimetic was prepared using silk fibroin (SF)/sodium alginate (SA) which regular uniform pore morphology can be formed through a facile freeze-dried method. The scanning electron microscopy (SEM) studies showed presence interconnected pores, mostly spread over entire with diameter around 54~532 μm...
Fibrotic stroma, a critical character of pancreatic tumor microenvironment, provides barrier against the penetration and efficacy various antitumor drugs. Therefore, new strategies are urgently needed to alleviate fibrotic mass increase drug perfusion within cancer tissue. In our current work, we developed β-cyclodextrin (β-CD) modified matrix metalloproteinase-2 (MMP-2) responsive liposome, integrating antifibrosis chemotherapeutic drugs for regulation stellate cells (PSCs), key source...
Platinum (Pt)-based chemotherapy is a broadly used therapeutic regimen against various cancers. However, the insufficient cellular uptake, deactivation by thiol-containing species and nonspecific distribution of cisplatin (CDDP) result in its low chemosensitivity as well systemic side effects, which can largely constrain employment CDDP clinical treatment. To circumvent these problems, this study, polymeric nanoparticles were utilized to codeliver water-soluble derivative, poly(γ,l-glutamic...
Abstract Due to their ability elicit a potent immune reaction with low systemic toxicity, cancer vaccines represent promising strategy for treating tumors. Considerable effort has been directed toward improving the in vivo efficacy of vaccines, direct lymph node (LN) targeting being most approach. Here, click‐chemistry‐based active LN accumulation system (ALAS) is developed by surface modification lymphatic endothelial cells an azide group, which provide targets dibenzocyclooctyne...
Metastasis remains the major cause of death in cancer patients. Thus, there is a need to sensitively detect tumor metastasis, especially ultrasmall for early diagnosis and precise treatment cancer. Herein, an ultrasensitive T1 -weighted magnetic resonance imaging (MRI) contrast agent, UMFNP-CREKA reported. By conjugating manganese ferrite nanoparticles (UMFNPs) with tumor-targeting penta-peptide CREKA (Cys-Arg-Glu-Lys-Ala), breast metastases are accurately detected. With behavior similar...
Solar interfacial evaporation is an emerging technology in solar energy harvesting developed to remedy the global crisis and lack of freshwater resources. However, developing fully enhanced thermal management optimize solar-heat utilization efficiency form remains a great challenge. We created synergistic photothermal layer from poly(N-phenylglycine) (PNPG)/MoS2 nanohybrid via electrostatic-induced self-assembly for broad-spectrum efficient absorption. The PNPG/MoS2 system provided effective...
Advanced textiles for personal thermal management (PTM) are more precise and energy-saving than traditional heating/cooling strategies. Applying phase change materials (PCMs) in PTM is sustainable effective but challenging due to the intrinsic rigid character of PCMs leakage issue transition. In this work, we employed poly(ethylene glycol) (PEG) as a functional material poly(vinyl alcohol) (PVA) polymer skeleton by green electrospinning endow composite membranes with superior flexibility,...
Trained immunity refers to the innate immune system building memory-like features in response subsequent infections and vaccinations. Compared with classical tumor vaccines, trained immunity-related vaccines (TIrV) are independent of tumor-specific antigens. Bacterial outer membrane vesicles (OMVs) contain an abundance PAMPs have potential act as TIrV-inducer, but face challenges endotoxin tolerance, systemic delivery, long-term training, tumor-associated macrophage (TAM)-mediated antitumor...
Manipulating the tumor immune contexture towards a more active state can result in better therapeutic outcomes. Here we describe an easily accessible bacterial biomineralization-generated immunomodulator, which name Ausome (Au + [exo]some). comprises gold nanoparticle core covered by components; former affords inducible hyperthermia effect, while latter mobilizes diverse responses. Multiple pattern recognition receptors actively participate Ausome-initiated responses, lead to release of...