A5105368829- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Gold and Silver Nanoparticles Synthesis and Applications
- Advanced Nanomaterials in Catalysis
- Bone Tissue Engineering Materials
- Asymmetric Synthesis and Catalysis
- Immunotherapy and Immune Responses
- Extracellular vesicles in disease
- Virus-based gene therapy research
- Nanoparticles: synthesis and applications
- Bacteriophages and microbial interactions
- Graphene and Nanomaterials Applications
- Quantum Dots Synthesis And Properties
- Collagen: Extraction and Characterization
- Asymmetric Hydrogenation and Catalysis
- Synthetic Organic Chemistry Methods
- Electrochemical Analysis and Applications
- Dental Implant Techniques and Outcomes
- Electrochemical sensors and biosensors
- Luminescence Properties of Advanced Materials
- Nanocluster Synthesis and Applications
- Immune cells in cancer
- Electrospun Nanofibers in Biomedical Applications
Xiamen University
2016-2025
Tiangong University
2025
Hebei North University
2025
Central Hospital of Zibo
2024
Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai)
2022-2024
Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)
2022-2024
Sun Yat-sen University
2022-2024
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
2024
Zhongda Hospital Southeast University
2024
State Key Laboratory of Digital Medical Engineering
2024
An effective tumor vaccine vector that can rapidly display neoantigens is urgently needed. Outer membrane vesicles (OMVs) strongly activate the innate immune system and are qualified as immunoadjuvants. Here, we describe a versatile OMV-based platform to elicit specific anti-tumor response via specifically presenting antigens onto OMV surface. We first on OMVs surface by fusing with ClyA protein, then simplify antigen process employing Plug-and-Display comprising tag/catcher protein pairs....
Combination therapeutic regimen is becoming a primary direction for current cancer immunotherapy to broad the antitumor response. Functional nanomaterials offer great potential steady codelivery of various drugs, especially small molecules, peptides, and nucleic acids, thereby realizing controllable drug release, increase bioavailability, reduction adverse effects. Herein, peptide assembling nanoparticle that can sequentially respond dual stimuli in tumor extracellular matrix was designed...
Natural, extracellular membrane vesicles secreted by Gram-negative bacteria, outer (OMVs), contain numerous pathogen-associated molecular patterns which can activate systemic immune responses. Previous studies have shown that OMVs induce strong IFN-γ- and T cell-mediated anti-tumor effects in mice. However, IFN-γ is known to upregulate immunosuppressive factors the tumor microenvironment, especially checkpoint programmed death 1 ligand (PD-L1), may hamper cell function limit...
In treatment of hypoxic tumors, oxygen-dependent photodynamic therapy (PDT) is considerably limited. Herein, a new bimetallic and biphasic Rh-based core-shell nanosystem (Au@Rh-ICG-CM) developed to address tumor hypoxia while achieving high PDT efficacy. Such porous Au@Rh nanostructures are expected exhibit catalase-like activity efficiently catalyze oxygen generation from endogenous hydrogen peroxide in tumors. Coating with cell membrane (CM) enables targeting via homologous binding. As...
Therapeutic mRNA vaccination is an attractive approach to trigger antitumor immunity. However, the delivery technology for customized tumor vaccine still limited. In this work, bacteria-derived outer membrane vesicles (OMVs) are employed as platform by genetically engineering with surface decoration of RNA binding protein, L7Ae, and lysosomal escape listeriolysin O (OMV-LL). OMV-LL can rapidly adsorb box C/D sequence-labelled antigens through L7Ae (OMV-LL-mRNA) deliver them into dendritic...
The abuse of antibiotics makes bacterial infection an increasingly serious global health threat. Reactive oxygen species (ROS) are the ideal alternative antibacterial approach for quick and effective sterilization. Although various strategies based on ROS have been developed, many them still limited by insufficient efficiency. Here, we developed acid-enhanced dual-modal strategy zeolitic imidazolate frameworks-8 (ZIF8) -derived nanozyme. ZIF8, which can release Zn
Abstract Tumor antigens released from tumor cells after local photothermal therapy (PTT) can activate the tumor‐specific immune responses, which are critical for eliminating residual lesions and distant metastases. However, limited recognition efficiency of by system immunosuppressive microenvironment lead to ineffective antitumor immunity. Here, an in situ multifunctional vaccine based on bacterial outer membrane vesicles (OMVs, 1‐MT@OMV‐Mal) is developed surface conjunction maleimide...
Nanozymes with peroxidase-like activity have great application potential in combating pathogenic bacterial infections and are expected to become an alternative antibiotics. However, the near-neutral pH high glutathione (GSH) levels infection microenvironment severely limit their applications antibacterial therapy. In this work, a metal–organic framework (MOF)-based cascade catalytic glutathione-depleting system named MnFe2O4@MIL/Au&GOx (MMAG) was constructed. The MMAG cascade-catalyzed...
Reactive oxygen species (ROS) plays important roles in living organisms. While ROS is a double-edged sword, which can eliminate drug-resistant bacteria, but excessive levels cause oxidative damage to cells. A core-shell nanozyme, CeO
We report that ultra-small, monodisperse, water-dispersible magnetite (Fe3O4) nanoparticles can be synthesized by a facile one-pot approach using trisodium citrate as crystal grain growth inhibitor and stabilizer in polyol solution. The resultant Fe3O4 exhibit an excellent long-term colloidal stability various buffer solutions without any modification. They are also superparamagnetic at room temperature their magnetic property relies heavily on size. Due to the low magnetization good...
A gadolinium-doped multi-shell upconversion nanoparticle under 800 nm excitation is synthesized with a 10-fold fluorescence-intensity enhancement over that 980 nm. The nanoformulations exhibit excellent photoacoustic/luminescence/magnetic resonance tri-modal imaging capabilities, enabling visualization of tumor morphology and microvessel distribution at new depth. As service to our authors readers, this journal provides supporting information supplied by the authors. Such materials are peer...
In recent years, hepatitis B core protein virus-like particle (HBc VLP) is an impressive biomaterial, which has attracted considerable attention due to favorable properties such as structural stability, high uptake efficiency, and biocompatibility in biomedical applications. Heretofore, only a few attempts have been made apply it physical, chemical, biological therapy for cancer. this study, tumor-targeting RGD-HBc VLP first fabricated through genetic engineering. For image-guided cancer...
A variety of chiral bisphosphoric acids derived from binaphthols have been evaluated for enantioselective 1,3-dipolar cycloaddition reactions, revealing that the feature linker in catalysts exerted great impact on stereoselectivity. Among them, oxygen-linked acid 1a provided highest level stereoselectivity reaction tolerating a wide range substrates including azomethine ylides, generated situ broad scope aldehydes and α-amino esters, various electron-deficient dipolarophiles such as...
Cooperation is key! Chiral Brønsted acid/rhodium(II) cooperative catalysis enabled an enantioselective three-component aldol-type reaction of 3-diazo oxindoles and anilines with glyoxylates to give highly functionalized structurally diverse 3-amino in high stereoselectivity (>20:1 d.r., 99 % ee; see scheme).
The limited efficacy of single-agent immune checkpoint inhibitors in treating tumors has prompted investigations on their combination partners. Here, a tumor-homing indoleamine 2,3-dioxygenase (IDO) nanoinhibitor is reported to selectively inhibit immunosuppressive IDO pathway the tumor microenvironment. It self-assembled from modularly designed peptide-drug conjugate containing hydrophilic targeting motif (arginyl-glycyl-aspartic acid; RGD), two protonatable histidines, and an ester...
Gold-based nanostructures with tunable wavelength of localized surface plasmon resonance (LSPR) in the second near-infrared (NIR-II) biowindow receive increasing attention phototheranostics. In view limited progress on NIR-II gold nanostructures, a particular liposome template-guided route is explored to synthesize novel nanoframeworks (AuNFs) large mesopores (≈40 nm) for multimodal imaging along therapeutic robustness. The synthesized AuNFs exhibit strong absorbance region, affording their...
The delineation of brain gliomas margins still poses challenges to precise imaging and targeted therapy, mainly due strong light attenuation the skull high background interference. With deep penetration sensitivity, photoacoustic (PA) (PAI) in second near-infrared (NIR II) window holds great potential for imaging. Herein, mesoionic dye A1094 encapsulated Arg-Gly-Asp-modified hepatitis B virus core protein (RGD-HBc) is designed synthesized effective NIR II PAI gliomas. An aggregation-induced...
Surface-enhanced Raman scattering (SERS) spectroscopy affords a rapid, highly sensitive, and nondestructive approach for label-free fingerprint diagnosis of wide range chemicals. It is great significance to develop large-area, uniform, environmentally friendly SERS substrates in situ identification analytes on complex topological surfaces. In this work, we demonstrate biodegradable flexible film via irreversibly longitudinally stretching metal deposited biocompatible poly(ε-caprolactone)...
This study reports a multifunctional nanoparticle (NP) that can be used for amplified magnetic resonance image (MRI)-guided photothermal therapy (PTT) due to its surface coating with polydopamine (PDA) shell. Importantly, by means of introducing the PDA, large quantities water trapped around NPs allowing more efficient exchange, leading greatly improved MR contrast signals compared those from without PDA coating. Further, distinct effect obtained arising strong absorption in near-infrared...
Metastasis remains the major cause of death in cancer patients. Thus, there is a need to sensitively detect tumor metastasis, especially ultrasmall for early diagnosis and precise treatment cancer. Herein, an ultrasensitive T1 -weighted magnetic resonance imaging (MRI) contrast agent, UMFNP-CREKA reported. By conjugating manganese ferrite nanoparticles (UMFNPs) with tumor-targeting penta-peptide CREKA (Cys-Arg-Glu-Lys-Ala), breast metastases are accurately detected. With behavior similar...
The characteristic hypoxia of solid tumors and inadequate oxygen supply become a key causation the resistance to chemotherapy in cancer treatment. Herein, bimetallic nanogenerator, i.e., porous Au@Pt core–shell nanostructures, is particularly developed reduce multidrug by oxygenating tumor along with synergistic chemo-photothermal therapy for efficient eradication. platinum (Pt) shell was able catalyze generation from endogenous hydrogen peroxide tumor, reducing exocytosis doxorubicin (DOX)...