Focusing light deep inside living tissue has not been achieved despite its promise to play a central role in biomedical imaging, optical manipulation and therapy. To address this challenge, internal-guide-star-based wavefront engineering techniques—for example, time-reversed ultrasonically encoded (TRUE) focusing—were developed. The speeds of these techniques, however, were limited no greater than 1 Hz, preventing them from vivo applications. Here we improve the speed focusing scattering...

Abstract Many hydrogel patches are developed to solve the pervasive and severe challenge of complex wound healing, while most them still lack satisfactory controllability comprehensive functionality. Herein, inspired by multiple creatures, including octopuses snails, a novel muti‐functional patch is presented with controlled adhesion, antibacterial, drug release features, monitoring functions for intelligent healing management. The micro suction‐cup actuator array tensile backing layer...

Abstract Artificial intelligence has gained significant attention for exploiting optical scattering encryption. Conventional media are inevitably influenced by instability or perturbations, and hence unsuitable long-term scenarios. Additionally, the plaintext can be easily compromised due to single channel within medium one-to-one mapping between input output. To mitigate these issues, a stable spin-multiplexing disordered metasurface (DM) with numerous polarized transmission channels serves...

The delineation of brain gliomas margins still poses challenges to precise imaging and targeted therapy, mainly due strong light attenuation the skull high background interference. With deep penetration sensitivity, photoacoustic (PA) (PAI) in second near-infrared (NIR II) window holds great potential for imaging. Herein, mesoionic dye A1094 encapsulated Arg-Gly-Asp-modified hepatitis B virus core protein (RGD-HBc) is designed synthesized effective NIR II PAI gliomas. An aggregation-induced...

Iterative wavefront shaping is a powerful tool to overcome optical scattering and enable the focusing of diffusive light, which has exciting potential in many applications that desire localized light delivery at depths tissue-like complex media. Unsatisfactory performance efficiency, however, have been long-standing problem, large discrepancy between theoretical experimental results hindered wide technology. Currently, most algorithms guiding iterative search for optimum phase compensation...

Abstract Early diagnosis can effectively improve the survival of glioblastoma multiforme (GBM). A specific imaging technique that is simultaneously deep penetrating and sensitive to small tissue changes desired identify GBM. Due its excellent features in signal contrast, detection sensitivity, none or little attenuation tissue, magnetic particle (MPI) possesses great potential cancer diagnosis, especially when modality equipped with specifically targeted nanoprobes. However, gliomas are...

Intralipid is widely used as an optical scattering agent in tissue-mimicking phantoms. Accurate control when using critical to match the diffusivity of phantoms prescribed value. Currently, most protocols Intralipid-based hydrogel phantom fabrication focus on factors such brand and concentration. In this note, for first time our knowledge, we explore dependence reduced coefficient (at 532 nm wavelength) temperature mixing with gelatin-water solution. The studied samples contained 1% were...

Multiple light scattering has been regarded as a barrier in imaging through complex media such biological tissues. Owing to recent advances wavefront shaping techniques, optical intact tissues without invasive procedures can now be used for direct experimental studies, presenting promising application opportunities vivo and diagnosis. Although most of the proof principle breakthroughs have achieved laboratory setting with specialties physics engineering, we anticipate that these technologies...

Rheumatoid arthritis (RA) is an autoimmune disease that often causes progressive joint dysfunction, even disability and death in severe cases. The radical improvement of inflammatory cell infiltration the resulting disorder oxygen supply a novel therapeutic direction for RA. Herein, near-infrared-absorbing metal/semiconductor composite, polyethylene glycol-modified ceria-shell-coated gold nanorod (Au@CeO2), fabricated topical photothermal/oxygen-enriched combination therapy RA mouse model....

Light scattering inside disordered media poses a significant challenge to achieve deep depth and high resolution simultaneously in biomedical optical imaging. Wavefront shaping emerged recently as one of the most potential methods tackle this problem. So far, numerous algorithms have been reported, while each has its own pros cons. In article, we exploit new thought that algorithm can be reinforced by another complementary since they effectively compensate other’s weaknesses, resulting more...

Abstract A communication channel should be built to transmit information from one place another. Imaging is 2 or higher dimensional communication. Conventionally, an imaging comprises a lens with free space at its both sides, whose transfer function usually known and hence the response of can well defined. Replacing thin scattering medium, image still extracted detected optical field, suggesting that medium retains reconstructs not only energy but also transmission channels. Aided by deep...

Abstract Brain voltage plays a crucial role in indicating internal functions or diseases, and optical imaging has gained intensive attention recent years. Despite encouraging progress, current implementations encounter limitations pertaining to penetration depth, field of view (FOV), photostability indicators. To mitigate these challenges, robust voltage‐sensitive dye (VSD)‐based whole‐field photoacoustic brain detection (WF‐PABD) platform is proposed, enabling direct evaluation dynamics...

Phase distortions due to scattering in random media restrict optical focusing beyond one transport mean free path. However, can be compensated for by applying a correction the illumination wavefront using spatial light modulators. One method of obtaining is iterative determination an optimization algorithm. In past, feedback signal required either direct access target region, or invasive embedding molecular probes within media. Here, we propose ultrasonically encoded as guide dynamically and...

Water and its distribution transport dynamics in green plant leaves are vital to the growth of plants. Owing high sensitivity terahertz (THz) wave water, THz spectroscopy has great advantages analyzing water status leaves. This paper presents a new approach estimate by time-domain (THz-TDS) technique. Spatial transmission amplitudes located vein xylem mesophyll all three kinds including wintersweet, ginkgo, bamboo is detected THz-TDS measurements. Based on amplitude, reconstructed images...

Optical imaging through or inside scattering media, such as multimode fiber and biological tissues, has a significant impact in biomedicine yet is considered challenging due to the strong nature of light. In past decade, promising progress been made field, largely benefiting from invention iterative optical wavefront shaping, with which deep-tissue high-resolution focusing hence becomes possible. Most reported algorithms can overcome small perturbations on noise level but fail effectively...

Optical focusing through scattering media is of great significance yet challenging in lots scenarios, including biomedical imaging, optical communication, cybersecurity, three-dimensional displays, etc. Wavefront shaping a promising approach to solve this problem, but most implementations thus far have only dealt with static media, which, however, deviates from realistic applications. Herein, we put forward deep learning-empowered adaptive framework, which specifically implemented by...

Optical-resolution photoacoustic microscopy (OR-PAM) enjoys superior spatial resolution and has received intense attention in recent years. The application, however, been limited to shallow depths because of strong scattering light biological tissues. In this work, we propose achieve deep-penetrating OR-PAM performance by using deep learning enabled image transformation on blurry living mouse vascular images that were acquired with an acoustic-resolution (AR-PAM) setup. A generative...

Abstract Face recognition has become ubiquitous for authentication or security purposes. Meanwhile, there are increasing concerns about the privacy of face images, which sensitive biometric data and should be protected. Software‐based cryptosystems widely adopted to encrypt but level is limited by insufficient digital secret key length computing power. Hardware‐based optical can generate enormously longer keys enable encryption at light speed, most reported methods, such as double random...