Jussi Hepojoki
A5071539719- Viral Infections and Vectors
- Viral Infections and Outbreaks Research
- SARS-CoV-2 and COVID-19 Research
- Animal Virus Infections Studies
- Fire effects on ecosystems
- Rabies epidemiology and control
- COVID-19 Clinical Research Studies
- Vector-Borne Animal Diseases
- Virus-based gene therapy research
- SARS-CoV-2 detection and testing
- Mosquito-borne diseases and control
- Viral gastroenteritis research and epidemiology
- Hepatitis B Virus Studies
- Plant Virus Research Studies
- Vector-borne infectious diseases
- Viral Infections and Immunology Research
- Bacteriophages and microbial interactions
- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- Respiratory viral infections research
- Monoclonal and Polyclonal Antibodies Research
- interferon and immune responses
- Diabetes Management and Research
- Diabetes and associated disorders
- Advanced Biosensing Techniques and Applications
University of Zurich
2017-2025
University of Helsinki
2016-2025
Finnish Institute for Health and Welfare
2021
Hospital District of Helsinki and Uusimaa
2021
Helsinki University Hospital
2016-2021
University of Göttingen
2020
The causative agent of coronavirus disease 2019 (COVID-19) is the severe acute respiratory syndrome 2 (SARS-CoV-2). For many viruses, tissue tropism determined by availability virus receptors and entry cofactors on surface host cells. In this study, we found that neuropilin-1 (NRP1), known to bind furin-cleaved substrates, significantly potentiates SARS-CoV-2 infectivity, an effect blocked a monoclonal blocking antibody against NRP1. A mutant with altered furin cleavage site did not depend...
Abstract SARS-Cov-2 (severe acute respiratory disease coronavirus 2), which causes Coronavirus Disease 2019 (COVID19) was first detected in China late and has since then caused a global pandemic. While molecular assays to directly detect the viral genetic material are available for diagnosis of infection, we currently lack serological suitable specifically SARS-CoV-2 antibodies. Here describe enzyme-linked immunosorbent (ELISA) that developed using recombinant antigens derived from spike...
The first case of coronavirus disease (COVID-19) in Finland was confirmed on 29 January 2020. No secondary cases were detected. We describe the clinical picture and laboratory findings 3-23 days since symptoms. SARS-CoV-2/Finland/1/2020 virus strain isolated, genome showing a single nucleotide substitution to reference from Wuhan. Neutralising antibody response appeared within 9 along with specific IgM IgG response, targeting particularly nucleocapsid spike proteins.
Abstract As SARS-CoV-2 has been circulating for over a year, dozens of vaccine candidates are under development or in clinical use. The BNT162b2 mRNA COVID-19 induces spike protein-specific neutralizing antibodies associated with protective immunity. emergence the B.1.1.7 and B.1.351 variants raised concerns reduced efficacy increased re-infection rates. Here we show, that after second dose, sera BNT162b2-vaccinated health care workers (n = 180) effectively neutralize variant D614G...
HighlightsImmunomonitoring from acute to recovery phase COVID-19An IFNγ-eosinophil axis precedes lung hyperinflammationBasophils modulate SARS-CoV-2 IgG responsesA shared trajectory of immunological in COVID-19SummarySevere disease is characterized by vigorous inflammatory responses the lung, often with a sudden onset after 5–7 days stable disease. Efforts this hyperinflammation and associated respiratory distress syndrome rely on unraveling immune cell interactions cytokines that drive such...
Viral infections may trigger type 1 diabetes (T1D), and recent reports suggest an increased incidence of paediatric T1D and/or diabetic ketoacidosis (DKA) during the COVID-19 pandemic.To study whether number children admitted to intensive care unit (PICU) for DKA due new-onset pandemic, SARS-CoV-2 infection plays a role.This retrospective cohort comprises two datasets: (1) PICU (2) diagnosed with registered Finnish Pediatric Diabetes Registry in Helsinki University Hospital from April 31...
ABSTRACT Hantaviruses (family Bunyaviridae ) are rodent-borne emerging viruses that cause a serious, worldwide threat to human health. Hantavirus diseases include hemorrhagic fever with renal syndrome and hantavirus cardiopulmonary syndrome. Virions enveloped contain tripartite single-stranded negative-sense RNA genome. Two types of glycoproteins, G N C , embedded in the viral membrane form protrusions, or “spikes.” The encloses ribonucleoprotein core, which consists segments, nucleocapsid...
ABSTRACT Boid inclusion body disease (BIBD) is a progressive, usually fatal of constrictor snakes, characterized by cytoplasmic bodies (IB) in wide range cell types. To identify the causative agent disease, we established cultures from BIBD-positive and -negative boa constrictors. The IB phenotype was maintained cultured cells affected animals, supernatants these caused originating BIBD-negative snakes. Viruses were purified ultracentrifugation subsequently identified as arenaviruses....
SUMMARY The causative agent of the current pandemic and coronavirus disease 2019 (COVID-19) is severe acute respiratory syndrome 2 (SARS-CoV-2) 1 . Understanding how SARS-CoV-2 enters spreads within human organs crucial for developing strategies to prevent viral dissemination. For many viruses, tissue tropism determined by availability virus receptors on surface host cells Both SARS-CoV use angiotensin-converting enzyme (ACE2) as a receptor, yet, their tropisms differ 3-5 Here, we found that...
Members of the family Arenaviridae produce enveloped virions containing genomes consisting two or three single-stranded RNA segments totalling about 10.5 kb. Arenaviruses can infect mammals, including humans and other primates, snakes, fish. This is a summary International Committee on Taxonomy Viruses (ICTV) Report , which available at www.ictv.global/report/arenaviridae .
Galectin-3-binding protein (Gal-3BP) is a ubiquitous and multifunctional secreted glycoprotein originally identified mainly studied in the context of neoplastic transformation cancer progression. However, Gal-3BP expression induced viral infection by multitude molecules that either mimic or are characteristic for an ongoing inflammation microbial infection, such as IFN-α, IFN-β, IFN-γ, TNF-α, poly(I:C), dsRNA, dsDNA. Furthermore, belongs to scavenger receptor cysteine-rich (SRCR)...
Hepatitis D virus (HDV) forms the genus Deltavirus unassigned to any family. HDV is a satellite and needs hepatitis B (HBV) make infectious particles. Deltaviruses are thought have evolved in humans, since for long time, they had not been identified elsewhere. Herein we report, prompted by recent discovery of an HDV-like agent birds, identification deltavirus snakes (Boa constrictor) designated snake (sHDV). The circular 1,711-nt RNA genome sHDV resembles human (hHDV) its coding strategy...
The newly identified tick-borne Alongshan virus (ALSV), a segmented Jingmen group flavivirus, was recently associated with human disease in China. We report the detection of ALSV RNA Ixodes ricinus ticks south-eastern Finland. Screening sera from patients suspected for encephalitis tick virus-like and antibodies revealed no cases. presence common European warrants further investigations on its role as pathogen.
Arenaviridae is a family for ambisense RNA viruses with genomes of about 10.5 kb that infect mammals, snakes, and fish. The arenavirid genome consists two or three single-stranded segments encodes nucleoprotein (NP), glycoprotein (GP) large (L) protein containing RNA-directed polymerase (RdRP) domains; some arenavirids encode zinc-binding (Z). This summary the International Committee on Taxonomy Viruses (ICTV) report Arenaviridae, which available at www.ictv.global/report/arenaviridae.
Abstract Mitochondria are critical modulators of antiviral tolerance through the release mitochondrial RNA and DNA (mtDNA mtRNA) fragments into cytoplasm after infection, activating virus sensors type-I interferon (IFN-I) response 1–4 . The relevance these mechanisms for diseases remains understudied. Here we investigated recessive ataxia syndrome (MIRAS), which is caused by a common European founder mutation in polymerase gamma ( POLG1 ) 5 Patients homozygous MIRAS variant p.W748S show...