Pierre Formenty
A5042407414- Viral Infections and Outbreaks Research
- Viral Infections and Vectors
- COVID-19 epidemiological studies
- Disaster Response and Management
- Zoonotic diseases and public health
- Mosquito-borne diseases and control
- Viral gastroenteritis research and epidemiology
- Poxvirus research and outbreaks
- Virology and Viral Diseases
- Herpesvirus Infections and Treatments
- Vector-Borne Animal Diseases
- Hepatitis B Virus Studies
- Plant Virus Research Studies
- Bacillus and Francisella bacterial research
- Fire effects on ecosystems
- HIV Research and Treatment
- Animal Disease Management and Epidemiology
- Bacteriophages and microbial interactions
- COVID-19 Digital Contact Tracing
- Primate Behavior and Ecology
- Vaccine Coverage and Hesitancy
- Yersinia bacterium, plague, ectoparasites research
- Global Security and Public Health
- Plant and Fungal Interactions Research
- Respiratory viral infections research
World Health Organization
2016-2025
World Health Organization - Pakistan
2007-2021
National Security Agency
2020
Computer Emergency Response Team
2008-2016
Institut Pasteur
1999-2010
Centers for Disease Control and Prevention
2010
National Public Health Laboratory
2010
Médecins Sans Frontières
2010
World Health Organization Regional Office for the Eastern Mediterranean
2010
Federal Ministry of Health
2010
In March 2014, the World Health Organization was notified of an outbreak a communicable disease characterized by fever, severe diarrhea, vomiting, and high fatality rate in Guinea. Virologic investigation identified Zaire ebolavirus (EBOV) as causative agent. Full-length genome sequencing phylogenetic analysis showed that EBOV from Guinea forms separate clade relationship to known strains Democratic Republic Congo Gabon. Epidemiologic linked laboratory-confirmed cases with presumed first...
Several human and animal Ebola outbreaks have occurred over the past 4 years in Gabon Republic of Congo. The consisted multiple simultaneous epidemics caused by different viral strains, each epidemic resulted from handling a distinct gorilla, chimpanzee, or duiker carcass. These populations declined markedly during outbreaks, apparently as result infection. Recovered carcasses were infected variety suggesting that great apes virus introductions natural host. Surveillance mortality may help...
Studies on the burden of human monkeypox in Democratic Republic Congo (DRC) were last conducted from 1981 to 1986. Since then, population that is immunologically naïve orthopoxviruses has increased significantly due cessation mass smallpox vaccination campaigns. To assess current risk infection, we analyzed incidence trends a monkeypox-enzootic region. Active, population-based surveillance was nine health zones central DRC. Epidemiologic data and biological samples obtained suspected cases....
Human monkeypox was first recognized outside Africa in 2003 during an outbreak the USA that traced to imported virus (MPXV)-infected West African rodents. Unlike smallpox-like disease described Democratic Republic of Congo (DRC; a Basin country), appeared milder. Here, analyses compared clinical, laboratory and epidemiological features confirmed human case-patients, using data from outbreaks Basin, results suggested pathogenicity associated with viral strain. Genomic sequencing USA, Western...
In July and September 2007, miners working in Kitaka Cave, Uganda, were diagnosed with Marburg hemorrhagic fever. The likely source of infection the cave was Egyptian fruit bats (Rousettus aegyptiacus) based on detection virus RNA 31/611 (5.1%) bats, virus-specific antibody bat sera, isolation genetically diverse from tissues. isolates collected nine months apart, demonstrating long-term circulation. colony estimated to be over 100,000 animals using mark re-capture methods, predicting...
Twelve years after the Kikwit Ebola outbreak in 1995, virus reemerged Occidental Kasaï province of Democratic Republic Congo (DRC) between May and November 2007, affecting more than 260 humans causing 186 deaths. During this latter we conducted several epidemiological investigations to identify underlying ecological conditions animal sources. Qualitative social environmental data were collected through interviews with villagers by direct observation. The local populations reported no unusual...
A suspected case of sexual transmission from a male survivor Ebola virus disease (EVD) to his female partner (the patient in this report) occurred Liberia March 2015. (EBOV) genomes assembled blood samples the and semen sample were consistent with direct transmission. The shared three substitutions that absent all other Western African EBOV sequences distinct last documented chain before case. Combined epidemiologic data, genomic analysis provides evidence persistence infective for 179 days...
This report describes the first reported outbreak of human monkeypox in Republic Congo. Eleven confirmed and probable cases were observed during this outbreak, all less than 18 years old, most resided on grounds Government Hospital Impfondo. Molecular, virologic, serologic, diagnostic assays used to detect evidence (or orthopox) virus infection individuals with striking dermatologic other clinical manifestations. The majority experienced significant, symptomatic illnesses; there was one...
El Niño/Southern Oscillation related climate anomalies were analyzed by using a combination of satellite measurements elevated sea-surface temperatures and subsequent rainfall satellite-derived normalized difference vegetation index data. A Rift Valley fever (RVF) risk mapping model these data predicted areas where outbreaks RVF in humans animals expected occurred the Horn Africa from December 2006 to May 2007. The predictions subsequently confirmed entomological epidemiological field...
Ebola virus has been detected in the semen of men after their recovery from disease (EVD). We report presence RNA a cohort survivors EVD Sierra Leone.We enrolled convenience sample 220 adult male Leone, at various times discharge an treatment unit (ETU), two phases (100 participants were phase 1, and 120 2). Semen specimens obtained baseline tested by means quantitative reverse-transcriptase-polymerase-chain-reaction (RT-PCR) assay with use target sequences NP VP40 (in 1) or GP This study...
To facilitate rapid, unbiased, differential diagnosis of infectious diseases, we designed GreeneChipPm, a panmicrobial microarray comprising 29,455 sixty-mer oligonucleotide probes for vertebrate viruses, bacteria, fungi, and parasites. Methods nucleic acid preparation, random primed PCR amplification, labeling were optimized to allow the sensitivity required application with extracted from clinical materials cultured isolates. Analysis nasopharyngeal aspirates, blood, urine, tissue persons...
In Bangladesh, 4 outbreaks of Nipah virus infection were identified during the period 2001-2004.We characterized clinical features virus-infected individuals affected by these outbreaks. We classified patients as having confirmed cases if they had antibodies reactive with antigen. Patients considered to have probable symptoms consistent same time and in community cases.We 92 infection, 67 (73%) whom died. Although all age groups affected, 2 principally young persons (median age, 12 years);...
The 2018 Nigerian Lassa fever season saw the largest ever recorded upsurge of cases, raising concerns over emergence a strain with increased transmission rate. To understand molecular epidemiology this upsurge, we performed, for first time at epicenter an unfolding outbreak, metagenomic nanopore sequencing directly from patient samples, approach dictated by highly variable genome target pathogen. Genomic data and phylogenetic reconstructions were communicated immediately to authorities World...
We report on an Ebola virus disease (EVD) survivor who showed in seminal fluid 531 days after onset of disease. The persisting was sexually transmitted February 2016, about 470 symptoms, and caused a new cluster EVD Guinea Liberia.
Immediate priorities for control of the ongoing Ebola epidemic are early diagnosis, patient isolation, contact tracing, strict adherence to laboratory biosafety guidelines, barrier nursing procedures, use personal protective equipment by clinicians, and safe burials.