A5070256251- Rabies epidemiology and control
- Viral Infections and Vectors
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Microbial infections and disease research
- Liver Disease Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Bat Biology and Ecology Studies
- Viral gastroenteritis research and epidemiology
- HIV Research and Treatment
- Streptococcal Infections and Treatments
- HIV, Drug Use, Sexual Risk
- Higher Education Teaching and Evaluation
- Hepatitis Viruses Studies and Epidemiology
- Virology and Viral Diseases
- COVID-19 Clinical Research Studies
- Yersinia bacterium, plague, ectoparasites research
- SARS-CoV-2 detection and testing
- Animal Virus Infections Studies
- Liver Diseases and Immunity
- Viral Infections and Outbreaks Research
- Educational Technology in Learning
- Blood Pressure and Hypertension Studies
- HIV-related health complications and treatments
- E-Learning and Knowledge Management
Instituto de Salud Carlos III
2015-2024
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
2008-2024
Centro Nacional de Microbiologia
2012-2022
Central University Hospital of Asturias
2022
Fundación Estatal, Salud, Infancia y Bienestar Social, F.S.P.
2020
Hospital de Sant Joan Despí Moisès Broggi
2016
Hospital Del Mar
2015-2016
Hospital del Mar Research Institute
2016
Municipal Institute for Medical Research
2016
University Hospital Mútua de Terrassa
2016
Filoviruses, amongst the most lethal of primate pathogens, have only been reported as natural infections in sub-Saharan Africa and Philippines. Infections bats with ebolaviruses marburgviruses do not appear to be associated disease. Here we report identification dead insectivorous a genetically distinct filovirus, provisionally named Lloviu virus, after site detection, Cueva del Lloviu, Spain.
Abstract The aim of the study was to determine incidence viruses causing aseptic meningitis, meningoencephalitis, and encephalitis in Spain. This a prospective study, collaboration with 17 Spanish hospitals, including 581 cases (CSF from all sera 280): meningitis (340), meningoencephalitis (91), (76), febrile syndrome (7), other neurological disorders (32), 35 without clinical information. CSF were assayed by PCR for enterovirus (EV), herpesvirus (herpes simplex [HSV], varicella‐zoster...
Understanding the role of humans in dispersal predominately animal pathogens is essential for their control. We used newly developed Bayesian phylogeographic methods to unravel dynamics and determinants spread dog rabies virus (RABV) North Africa. Each countries studied exhibited largely disconnected spatial with major geo-political boundaries acting as barriers gene flow. Road distances proved be better predictors movement RABV than accessibility or raw geographical distance, occasional...
A new tentative lyssavirus, Lleida bat was found in a bent-winged (Miniopterus schreibersii) Spain. It does not belong to phylogroups I or II, and it seems be more closely related the West Causasian virus, especially Ikoma lyssavirus.
Summary Rabies is the oldest known zoonotic disease and was also first recognized bat associated infection in humans. To date, four different lyssavirus species are causative agents of rabies European bats: Bat Lyssaviruses type 1 2 (EBLV‐1, EBLV‐2), recently discovered putative new Bokeloh Lyssavirus (BBLV) West Caucasian Virus (WCBV). Unlike world, cases Europe comparatively less frequent, possibly as a result varying intensity surveillance. Thus, objective to provide an assessment...
Bat coronaviruses (CoV) are putative precursors of the severe acute respiratory syndrome (SARS) CoV and other that crossed species barrier from zoonotic reservoirs into human population. To determine presence distribution in Iberian bats, 576 individuals 26 different bat were captured 13 locations Spain. We report for first time 14 9 species. Phylogenetic analysis a conserved genome region (RdRp gene) shows wide diversity alpha betacoronavirus Interestingly, although some these viruses...
Rhabdoviruses infect a variety of hosts, including mammals, birds, reptiles, fish, insects and plants. As bats are the natural host for most members genus Lyssavirus , specificity amplification methods used active surveillance is usually restricted to lyssaviruses. However, presence other rhabdoviruses in has also been reported. In order broaden scope such methods, new RT-PCR, able detect diverse range rhabdoviruses, was designed. The method detected 81 86 different rhabdoviruses. total,...
Importance In the context of emerging SARS-CoV-2 variants or lineages and new vaccines, it is key to accurately monitor COVID-19 vaccine effectiveness (CVE) inform vaccination campaigns. Objective To estimate vaccines administered in autumn winter 2022 2023 against symptomatic infection (with all circulating viruses XBB lineage particular) among people aged 60 years older Europe, compare different CVE approaches across exposed reference groups used. Design, Setting, Participants This...
To determine the presence of European bat lyssavirus type 1 in southern Spain, we studied 19 colonies serotine bats (Eptesicus isabellinus), its main reservoir, during 1998-2003. Viral genome and antibodies were detected healthy bats, which suggests subclinical infection. The different temporal patterns circulation found each colony indicate independent endemic circulation.
Abstract Both hepatitis C virus (HCV) infection and human immunodeficiency (HIV) are underdiagnosed, particularly in low-income countries difficult-to-access populations. Our aim was to develop evaluate a methodology for the detection of HCV HIV based on capillary dry blood spot (DBS) samples taken under real-world conditions. We carried out cross-sectional study 139 individuals (31 healthy controls, 68 HCV-monoinfected patients, 40 HCV/HIV-coinfected patients). ELISA used anti-HCV anti-HIV...
A thorough search for bat herpesviruses was carried out in oropharyngeal samples taken from most of the species present Iberian Peninsula Vespertilionidae, Miniopteridae, Molossidae and Rhinolophidae families, addition to a colony captive fruit bats Pteropodidae family. By using two degenerate consensus PCR methods targeting conserved genes, distinct previously unrecognized bat-hosted were identified tested species. All together total 42 potentially novel partially characterized. Thirty-two...
Background and aims In comparison with men, women who use drugs (WWUD) have considerably more frequent intense experiences interpersonal violence, sexual abuse trauma. The aim of this study was to identify issues related gender-based vulnerability in a group WWUD attended harm reduction facility Madrid, Spain. Material methods A cross-sectional conducted during screening blood borne infections. We included (smoked or injected heroin/cocaine) were actively screened for HIV, HBV HCV setting...
Introducción: El Sistema de Vigilancia Infección Respiratoria Aguda (SiVIRA) en España se inició la temporada 2020-21, con paulatina incorporación las comunidades y ciudades autónomas. Se presentan los resultados SiVIRA durante 2023-24. Método: Como vigilancia sindrómica, recogieron todos casos que acudieron a consulta por infección respiratoria aguda atención primaria (IRA) o fueron ingresados IRA grave (IRAG) hospitales, calculándose tasas incidencia semanales ponderadas. seleccionó una...
This SOP describes a multiplex RT-qPCR assay for the detection and typing of respiratory syncytial virus (RSV) into subgroups A B, enabling simultaneous identification both targets in single reaction.
Abstract The mechanisms involved in the chronic hepatitis C progression are incompletely understood. aim was to analyze association between 2 ′ 5 oligoadenylate synthetase 1,2 and 3 (OAS1-3 ) myxovirus resistance proteins 1 (Mx1 polymorphisms severity of liver disease human immunodeficiency virus (HIV)/hepatitis (HCV) coinfected patients. We performed a cross-sectional study 219 patients that underwent biopsy. DNA genotyping for Mx1 (rs469390), OAS1 (rs2285934), OAS2 (rs1293762) OAS3...
In the context of long-term screening for viruses on Western Palaearctic bats, we tested presence adenovirus 1392 oropharyngeal swabs and 325 stool samples taken from 27 bat species. Adenoviruses were detected in 12 species Vespertilionidae Rhinolophidae families. Fifty positive respiratory 26 studied. Phylogenetic analyses partial hexon protein DNA-dependent DNA polymerase genes indicate that all these adenoviruses belong to genus Mastadenovirus but without constituting a monophyletic...
We documented a hematologic patient with prolonged SARS-CoV-2 viral replication in whom emergence of mutations was after the consecutive use antivirals and convalescent plasma. The virus detected last 12 clinical samples (day 237) had accumulated 22 changes amino acids 29 nucleotides. Some these changes, such as E484Q, were concern defined by WHO. This finding represents an enormous epidemiological threat poses major challenge. Combined antiviral strategies, well specific strategies related...
Abstract To better understand the epidemiology of European bat lyssavirus 1 (EBLV-1) in Europe, we phylogenetically characterized Lyssavirus from Eptesicus isabellinus bats Spain. An independent cluster EBLV-1 possibly resulted geographic isolation and association with a different reservoir other strains. phylogeny is complex probably associated host evolutionary history.
Rabies is a lethal and notifiable zoonotic disease for which diagnostics have to meet the highest standards. In recent years, an evolution was especially seen in molecular with wide variety of different detection methods published. Therefore, first international ring trial specifically designed on use reverse transcription polymerase chain reaction (RT-PCR) lyssavirus genomic RNA organized. The focussed assessment comparison performance conventional real-time assays. total, 16 European...