A5085669615- Mycotoxins in Agriculture and Food
- Viral gastroenteritis research and epidemiology
- Health Systems, Economic Evaluations, Quality of Life
- Receptor Mechanisms and Signaling
- Viral Infections and Immunology Research
- Meta-analysis and systematic reviews
- Synthesis and Biological Evaluation
- MicroRNA in disease regulation
- Carcinogens and Genotoxicity Assessment
- Liver Disease and Transplantation
- Hepatitis B Virus Studies
- RNA modifications and cancer
- Liver Disease Diagnosis and Treatment
- Drug Transport and Resistance Mechanisms
- Epigenetics and DNA Methylation
- Protein Degradation and Inhibitors
- Cancer therapeutics and mechanisms
- CRISPR and Genetic Engineering
- Viral Infections and Outbreaks Research
- Plant Disease Resistance and Genetics
- Cancer-related molecular mechanisms research
- Hepatitis C virus research
- Delphi Technique in Research
- Plant Pathogens and Resistance
- Circular RNAs in diseases
Zhejiang University
2023-2025
First Affiliated Hospital Zhejiang University
2023-2025
Chengdu Medical College
2023-2024
Qingdao University
2012-2024
Affiliated Hospital of Qingdao University
2015-2024
Huazhong Agricultural University
2015-2023
Guangzhou University of Chinese Medicine
2019
Beijing University of Posts and Telecommunications
2019
Guangxi University
2018
Foshan Hospital of TCM
2018
Salmonella is recognized as one of the most common microbial pathogens worldwide. The bacterium contains clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated (Cas) systems, providing adaptive immunity against invading foreign nucleic acids. Previous studies suggested that certain bacteria employ Cas proteins CRISPR-Cas systems to target their own genes, which also alters virulence during invasion mammals. However, whether in have similar functions bacterial...
Increasing studies have identified the potential of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) in non-alcoholic fatty liver disease (NAFLD) treatment. Hence, we further focused on adipose-derived MSC (ADSC)-EVs NAFLD by delivering miR-223-3p. The uptake isolated ADSC-EVs hepatocytes was assessed, and expression miR-223-3p characterized. It established that miR-223-3p, enriched ADSC-EVs, could be delivered into hepatocytes. Using co-culture system gain-of-function...
Adult hematopoietic stem cells (HSCs) homeostasis is critically important in maintaining lifelong hematopoiesis. However, how adult HSCs orchestrate its remains not fully understood. Imprinted gene Dlk1 has been shown to play critical role mouse embryonic hematopoiesis and regulation of cells, but physiological roles are unknown.We performed expression analysis Dlk1, constructed conditional knockout (KO) mice by crossing Mx1 cre with Dlkflox/flox mice. Western blot quantitative PCR were used...
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a novel phlebovirus that was identified to be the etiological pathogen of emerging infectious disease, severe (SFTS). SFTSV could transmitted through tick bite. Transmission among humans has also been reported mainly direct blood contact. In July 2014, cluster six suspected SFTS cases occurred in Shandong Province, China. this cluster, both symptomatic and asymptomatic persons were included. By analyzing clinical data results...
Acute myeloid leukemia (AML) is an aggressive and heterogeneous hematologic malignancy. In elderly patients, AML incidence high has a poor prognosis due to lack of effective therapies. G protein-coupled receptors (GPCR) play integral roles in physiologic processes human diseases. Particularly, one third adhesion GPCRs, the second largest group are highly expressed hematopoietic stem progenitor cells or lineage cells. Here, we investigate role GPCRs whether they could be harnessed as...
Hepatocellular carcinoma (HCC) is a common malignant tumor with high fatality rate. Recent studies reported that up-regulation of long non-coding RNA antisense in the INK4 locus (lncRNA ANRIL) was found HCC tissues, and which could affect cells biological processes. However, potential molecular mechanism ANRIL still unclear. The study aimed to uncover effect on HepG2 growth, migration invasion.
DNA methylation is a significant component in proximal chromatin regulation and plays crucial roles regulating gene expression maintaining the repressive state of retrotransposon elements. However, accurate profiling proteomics which simultaneously identifies specific sequences their associated epigenetic modifications remains challenge. Here, we report strategy termed SelectID (selective control at genome targets identified by dCas9), introduces methylated binding domain into dCas9-mediated...
Abstract Background Human adenovirus (HAdV) had been recognized as one of the most common enteric viruses associated with acute diarrhea in children. The present study was carried out to demonstrate molecular and epidemiological characterization HAdV Infections among children Shandong province China between July 2017 June 2018. Methods Fecal specimens were collected from under 5 years old diarrhea. DNA extracted stool detected by PCR amplification specific primers. products subjected...
Abstract Numerous studies have examined the prevalence of pathogenic Escherichia coli in poultry and products; however, limited data are available regarding their resistance- virulence-associated gene expression profiles. This study was designed to examine resistance virulence E. strains vitro vivo via antibiotic susceptibility, biofilm formation adhesion, invasion intracellular survivability assays Caco-2 Raw 264.7 cell lines as well determination median lethal dose two-day old chickens. A...
Nivalenol (NIV), a type B trichothecenes commonly found in cereal crops, can cause growth impairment animals. However, limited information about its mechanisms is available. Trichothecenes have been characterized as an inhibitor of protein synthesis and induce apoptosis cells. Oxidative stress considered underlying mechanism. whether NIV oxidative rat pituitary cells line GH3 unclear. The present study showed that significantly reduced the viability caused Further experiments nitric oxide...
A unique porous ternary MnTiO 3 /TiO 2 /C composite is obtained from Mn O /polyaniline precursor through the liquid phase deposition (LPD) method and subsequent carbonization process. When evaluated as anode materials for lithium ion batteries (LIBs), it displays enhanced electrochemical performance, including superior cycling stability (418 mAh g −1 after 200 cycles at 500 mA ), favorable rate capability (270 4 supernal coulombic efficiency (>98% cycles), compared with pristine...
Mequindox (MEQ), acting as an inhibitor of deoxyribonucleic acid (DNA) synthesis, is a synthetic heterocyclic N-oxides. To investigate the potential carcinogenicity MEQ, four groups Kun-Ming (KM) mice (50 mice/sex/group) were fed with diets containing MEQ (0, 25, 55, and 110 mg/kg) for one half years. The result showed adverse effects on body weights, feed consumption, hematology, serum chemistry, organ relative incidence tumors during most study period. Treatment-related changes in weights...