A5100622193- Cardiomyopathy and Myosin Studies
- HER2/EGFR in Cancer Research
- Ion Transport and Channel Regulation
- Advanced Breast Cancer Therapies
- Cancer Treatment and Pharmacology
- RNA modifications and cancer
- Genetic and phenotypic traits in livestock
- Genetic Mapping and Diversity in Plants and Animals
- Cancer-related molecular mechanisms research
- Genetic Syndromes and Imprinting
- Breast Cancer Treatment Studies
- Viral Infections and Immunology Research
- Cardiac Structural Anomalies and Repair
- Cancer Genomics and Diagnostics
- Microbial Community Ecology and Physiology
- Gut microbiota and health
- Congenital heart defects research
- Photosynthetic Processes and Mechanisms
- Metabolomics and Mass Spectrometry Studies
- Mitochondrial Function and Pathology
- Marine and coastal ecosystems
- Magnesium in Health and Disease
- Ginseng Biological Effects and Applications
- Autophagy in Disease and Therapy
- Cardiovascular Effects of Exercise
First Affiliated Hospital Zhejiang University
2020-2025
Sir Run Run Shaw Hospital
2022-2025
Zhejiang University
2020-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Binzhou University
2023-2025
Binzhou Medical University
2023-2025
Peking University
2018-2025
Peking University Cancer Hospital
2018-2025
Hong Kong University of Science and Technology
2017-2025
University of Hong Kong
2017-2025
BACKGROUND. While mitochondria play an important role in innate immunity, the relationship between mitochondrial dysfunction and inflammation heart failure (HF) is poorly understood. In this study we aimed to investigate mechanistic link inflammatory activation peripheral blood mononuclear cells (PBMCs), potential antiinflammatory effect of boosting NAD level.
Precipitation whiplash, including abrupt shifts between wet and dry extremes, can cause large adverse impacts on human natural systems. Here we quantify observed projected changes in characteristics of sub-seasonal precipitation whiplash investigate the role individual anthropogenic influences these changes. Results show that occurrence frequency global is to be 2.56 ± 0.16 times higher than 1979-2019 by end 21st Century, with increasingly rapid intense transitions two extremes. The most...
Objective Antimicrobial peptides (AMPs) play essential roles in maintaining gut health and are associated with IBD. This study is to elucidate the effect of angiogenin (ANG), an intestine-secreted AMP, on microbiota its relevance Design The ANG contribution colitis were evaluated different models co-housing faecal transplantation. ANG-regulated bacteria determined by 16S rDNA sequencing their functions analysed bacterial colonisation. species-specific antimicrobial activity underlying...
Abstract Background The yak is a symbol of the Qinghai-Tibet Plateau and provides important basic resources for human life on plateau. Domestic yaks have been subjected to strong artificial selection environmental pressures over long-term. Understanding molecular mechanisms phenotypic differences in populations can reveal key functional genes involved domestication process improve genetic breeding. Material method Here, we re-sequenced 80 (Maiwa, Yushu, Huanhu populations) identify...
Abstract The nucleolus is the organelle for ribosome biogenesis and sensing various types of stress. However, its role in regulating stem cell fate remains unclear. Here, we present evidence that nucleolar stress induced by interfering rRNA can drive 2-cell stage embryo-like (2C-like) program induce an expanded 2C-like population mouse embryonic (mES) cells. Mechanistically, integrity maintains normal liquid-liquid phase separation (LLPS) formation peri-nucleolar heterochromatin (PNH). Upon...
In hypertrophied and failing hearts, fuel metabolism is reprogrammed to increase glucose metabolism, especially glycolysis. This metabolic shift favors biosynthetic function at the expense of ATP production. Mechanisms responsible for switch are poorly understood. We found that inhibitory factor 1 mitochondrial FoF1-ATP synthase (ATPIF1), a protein known inhibit hydrolysis by reverse during ischemia, was significantly upregulated in pathological cardiac hypertrophy induced pressure overload,...
Methionine is an amino acid necessary for the growth and development of all animals. Glutathione produced during methionine metabolism can reduce damage to cells caused by oxidative stress. Supplementing restricted acids in animals scientific means will be beneficial protein synthesis, which affect bring huge economic benefits when applied actual production life. In this study, we collected three muscle tissues from 24 male Maiwa yaks, were fattened months with different concentrations their...
Bacterial extracellular vesicles (EVs) are secreted by bacteria into the environment. Containing DNA, RNA and proteins, EVs implicated to mediate intercellular communications. The marine cyanobacterium Prochlorococcus , most abundant photosynthetic organism in ecosystems, has been shown generate continuously during cell growth. However, biogenesis functions of released remain largely unclear. Here, we isolated characterized MED4 culture. We found that majority elliptical enriched with...
Non-small-cell lung cancer (NSCLC) is one of the most common cancers, and microRNAs (miRNAs) have been reported to play essential roles in NSCLC. Recent studies indicated that miR-330-3p expression up-regulated NSCLC samples tissues brain metastasis. In this study, up-regulation was confirmed 20 patient samples. Furthermore, over-expressed cell lines A549 H23, promotive function investigated regulating proliferation cycle distribution. To identify potential target genes NSCLC, miRNA...
Significance To adapt to the daily light–dark cycle, diurnal rhythms are used by photosynthetic cyanobacteria Prochlorococcus and Synechococcus , which most abundant organisms on earth. Field studies revealed that cyanobacterial virus (cyanophage) populations in oceans showed transcriptional rhythms. explore underlying mechanism, we cyanophage laboratory cultures find some adsorption all We discovered rhythm is partially caused activity of host cells, explaining field populations. Our study...
Candida albicans (C. albicans) infection remains a challenge to clinicians due the limited available antifungals. With widespread use of antifungals in clinic, drug resistance has been emerging continuously, especially fluconazole. Therefore, searching for new antifungals, active constituents natural or traditional medicines, and approaches overcome is needed. This study investigated activity Asiatic acid (AA) alone combination with fluconazole (FLC) against C. vitro vivo. The studies...
Liddle syndrome, an autosomal dominant form of monogenic hypertension, has been regarded as a rare disorder, which leads to many syndrome patients being misdiagnosed and experiencing severe complications at early age. Little is known about the prevalence syndrome. In this study, authors investigated confirmed by genetic testing among young hypertension undetermined causes in China. A total 330 hypertensive aged 14 40 years after exclusion common secondary were enrolled serum potassium...
Previous studies in yeast showed that mitochondrial stressors not directly targeting the protein import machinery can cause precursor overaccumulation stress (mPOS) cytosol independent of bioenergetics. Here, we demonstrate mPOS and responses human cells. We show overloading membrane carrier, but matrix proteins, is sufficient to induce cytosolic aggresomes apoptosis. The appear triage unimported proteins. Interestingly, expression highly unstable mutant variants carrier protein, Ant1, also...
Growing evidence demonstrates that the bioaccumulation of polystyrene nanoplastics (PS-NPs) in gastrointestinal tract has negative effects on health. Until now, little information been available regarding potential hazards PS-NPs to intestinal epithelial barriers. In this study, we employed cellular and animal models investigate adverse epithelium underlying mechanism. We found affected growth survival cells a time- concentration-dependent manner. accumulated cytoplasm, resulting an impaired...
Blocking host cell death is an important virulence strategy employed by many bacterial pathogens. We recently reported that Shigella flexneri inhibits pyroptosis delivering a type III secretion system (T3SS) effector OspC3 catalyzes novel arginine ADP-riboxanation modification on caspase-4/11. Here, we investigated the homologue CopC from Chromobacterium violaceum, opportunistic but sometimes deadly pathogen. bears same ADP-riboxanase activity as OspC3, with different substrate specificity....