A5077859875- Cardiomyopathy and Myosin Studies
- Renal and Vascular Pathologies
- Cerebrovascular and Carotid Artery Diseases
- Vasculitis and related conditions
- Cardiovascular Function and Risk Factors
- Peripheral Artery Disease Management
- Cardiovascular Effects of Exercise
- Hormonal Regulation and Hypertension
- Cardiovascular Health and Disease Prevention
- Blood Pressure and Hypertension Studies
- Congenital heart defects research
- Viral Infections and Immunology Research
- Vascular Procedures and Complications
- Adrenal and Paraganglionic Tumors
- Acute Ischemic Stroke Management
- Adrenal Hormones and Disorders
- Intracranial Aneurysms: Treatment and Complications
- Aortic aneurysm repair treatments
- Acute Kidney Injury Research
- Congenital Heart Disease Studies
- Cardiac Arrhythmias and Treatments
- Galectins and Cancer Biology
- MicroRNA in disease regulation
- Abdominal vascular conditions and treatments
- Atherosclerosis and Cardiovascular Diseases
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Fu Wai Hospital
2005-2022
Peking Union Medical College Hospital
2008-2018
Hypertension Institute
2017
State Key Laboratory of Cardiovascular Disease
2014-2016
Yantai Laiyang Central Hospital
2015
Academy of Medical Sciences
2014
Zero to Three
2014
The First Affiliated Hospital, Sun Yat-sen University
2013
Zhongshan Hospital
2013
Abstract The molecular mechanisms that drive the development of cardiac hypertrophy in hypertrophic cardiomyopathy ( HCM ) remain elusive. Accumulated evidence suggests micro RNA s are essential regulators remodelling. We have been suggested could play a role process . To uncover which were changed their expression, microarrays performed on heart tissue from patients n = 7) and healthy donors 5). Among 13 differentially expressed , miR‐451 was most down‐regulated. Ectopic overexpression...
To describe a large cohort of patients with Takayasu arteritis in China. We retrospectively analyzed 566 hospitalized Fuwai Hospital between 2002 and 2013. Data collected were clinical characteristics, laboratory findings, angiographic features, treatment, longterm outcome. The female to male ratio was 3.8 1, the mean age onset 28.9 ± 12.0 years. most common inflammatory symptom, initial coexisting disease fever (52, 9.2%), dizziness (214, 37.8%), hypertension (HTN; 392, 69.3%),...
Objective: To examine whether spironolactone could reduce the severity of obstructive sleep apnea (OSA) and lower blood pressure in patients with resistant hypertension. Methods: This was a blank-controlled, single-center study. Patients hypertension moderate-to-severe OSA (apnea–hypopnea index >15 events/h) were enrolled randomly assigned to therapy or control group. group administered 20 mg once daily (up 40 for 4 weeks, if required) addition original antihypertensive medication. Follow-up...
Risk stratification of young patients with hypertension remains challenging. Generally, machine learning (ML) is considered a promising alternative to traditional methods for clinical predictions because it capable processing large amounts complex data. We, therefore, explored the feasibility an ML approach predicting outcomes in and compared its performance that approaches now commonly used practice. Baseline data composite end point—comprising all-cause death, acute myocardial infarction,...
Abstract Cardiac hypertrophy has been known as an independent predictor for cardiovascular morbidity and mortality. Molecular mechanisms underlying the development of heart failure remain elusive. Recently, microRNAs (miRs) have established important regulators in cardiac hypertrophy. Here, we reported miR‐221 was up‐regulated both transverse aortic constricted mice patients with hypertrophic cardiomyopathy (HCM). Forced expression by transfection mimics increased myocyte cell size induced...
Sex plays an important role in the clinical expression and prognosis of various cardiovascular diseases. This study was designed to observe effects sex on hypertrophic cardiomyopathy (HCM).A total 621 unrelated patients with HCM without heart failure (460 males) were enrolled from 1999 2011. Compared male patients, at baseline female older diagnosis (49.6±17.2 years vs. 46.7±14.4 years, P = 0.033), had greater frequency left ventricular outflow tract obstruction (72/161, 44.7% 149/460,...
Background: MicroRNAs play a crucial role in the regulation of pathological cardiac remodeling and heart failure. Previously, we found that overexpression miR-221 induces failure mice. The miR-222 share same gene cluster, however, function remained ill-defined. Methods Results: Transgenic mice with cardiac-specific expression (Tg-miR-222) were generated. Tg-miR-222 developed significantly enlarged hearts at 4 weeks age. Transthoracic echocardiograph data indicated exhibited an increased left...
Liddle syndrome, an autosomal dominant form of monogenic hypertension, has been regarded as a rare disorder, which leads to many syndrome patients being misdiagnosed and experiencing severe complications at early age. Little is known about the prevalence syndrome. In this study, authors investigated confirmed by genetic testing among young hypertension undetermined causes in China. A total 330 hypertensive aged 14 40 years after exclusion common secondary were enrolled serum potassium...
Modifier genes contribute to the diverse clinical manifestations of hypertrophic cardiomyopathy (HCM), but are still largely unknown. Muscle ring finger (MuRF) proteins a class muscle-specific ubiquitin E3-ligases that appear modulate cardiac mass and function by regulating ubiquitin-proteasome system. In this study we screened all three members MuRF family, MuRF1, MuRF2 MuRF3, in 594 unrelated HCM patients 307 healthy controls targeted resequencing. Identified rare variants were confirmed...
Background Elevated high‐sensitivity C‐reactive protein (hs CRP ) has been associated with increased risks of adverse outcomes various cardiovascular diseases. The relationship between hs and the prognosis hypertrophic cardiomyopathy remains to be evaluated. Methods Results study used an observational cohort methodology. A total 490 patients were enrolled in Fuwai Hospital from 2001 2011 followed for 3.7±2.0 years. According risk category , subjects high group (>3.0 mg/L) had a higher...
BACKGROUND: Serum troponins and CK-MB (creatine kinase-MB) are readily detectable reliable cardiac-specific biomarkers of subclinical myocardial injury. This study explores the roles cTnI (cardiac troponin I) in hypertrophic cardiomyopathy (HCM). METHODS: included 1045 patients with HCM who had baseline measurements at Fuwai Hospital between 1999 2019. Patients were excluded if they undergone percutaneous coronary intervention or artery bypass grafting, renal failure. Five end points...
Objectives: The clinical outcomes of hypertrophic cardiomyopathy (HCM) are largely unpredictable. This study aimed to investigate the relationship between atrial fibrillation (AF) and its prognostic implications in Chinese patients with HCM. Methods: From 1999 2011, 654 unrelated HCM were consecutively recruited at Fuwai Hospital. Medical history, including electrocardiographic echocardiographic data, was analyzed. Results: AF documented 158 (24%). During follow-up 4.2 ± 2.8 years,...
Background: The study aimed to analyze genes involved in Mendelian forms of low-renin hypertension Chinese early-onset hypertensive patients. Methods: A panel nine genes, namely SCNN1B, SCNN1G, WNK1, WNK4, KLHL3, CUL3, nuclear receptor subfamily 3, group C (NR3C)1, NR3C2, and HSD11B2 were screened by targeted resequencing 260 Additionally, exon 13 both SCNN1B SCNN1G was sequenced an independent cohort 506 Results: About 81 nonrare 41 rare variants were, respectively, detected 221 (85.0%) 39...
Abstract Background Filamin C ( FLNC ) mutation was reported as a cause of HCM, with high probability sudden cardiac death. However, the profile , and its relationship phenotypic expression in remains to be elucidated. Methods In this study, gene sequenced 540 HCM patients 307 healthy controls. Results We found that 39 (7.2%) carried mutations, similar frequency controls (4.2%, p = 0.101). Pedigree analysis showed mutations were not well segregated HCM. The baseline characteristics between...