A5101993222- Cardiomyopathy and Myosin Studies
- Cardiovascular Effects of Exercise
- Cardiovascular Function and Risk Factors
- Extracellular vesicles in disease
- Congenital heart defects research
- Peptidase Inhibition and Analysis
- Cardiac Arrhythmias and Treatments
- Autophagy in Disease and Therapy
- Cardiac Structural Anomalies and Repair
- Advanced biosensing and bioanalysis techniques
- Cardiovascular Disease and Adiposity
- Sulfur Compounds in Biology
- Biosensors and Analytical Detection
- RNA Research and Splicing
- Postharvest Quality and Shelf Life Management
- Muscle Physiology and Disorders
- Helicobacter pylori-related gastroenterology studies
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Gout, Hyperuricemia, Uric Acid
- Sports injuries and prevention
- Eosinophilic Disorders and Syndromes
- Signaling Pathways in Disease
- Coronary Artery Anomalies
- Congenital Heart Disease Studies
Shenyang Agricultural University
2024
Nanchang University
2024
Affiliated Hospital of Hangzhou Normal University
2023
Shanghai University
2021-2023
Tsinghua University
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2012-2022
Dalian Medical University
2021
South China Normal University
2020
Tianjin Medical University General Hospital
2020
Tianjin Medical University
2016-2018
Abstract The molecular mechanisms that drive the development of cardiac hypertrophy in hypertrophic cardiomyopathy ( HCM ) remain elusive. Accumulated evidence suggests micro RNA s are essential regulators remodelling. We have been suggested could play a role process . To uncover which were changed their expression, microarrays performed on heart tissue from patients n = 7) and healthy donors 5). Among 13 differentially expressed , miR‐451 was most down‐regulated. Ectopic overexpression...
This study investigated the protective effects of sodium alginate (SA) on gut microbiota, immunity, and intestinal mucosal barrier function in cyclophosphamide-induced immunosuppressed BALB/c mice. SA alleviated spleen tissue damage restored impaired immune functions, such as increasing organ index, decreasing splenic T lymphocytes, markedly secretion serum immunoglobulins cytokines In addition, reversed injury increased permeability by upregulating expression tight junction proteins....
Background Myocardial fibrosis contributes to adverse cardiovascular events in hypertrophic cardiomyopathy (HCM). Purpose To explore the characteristics of cardiac fibroblast activation protein inhibitor (FAPI) PET/CT imaging and its relationship with risk sudden death (SCD) HCM. Materials Methods In this prospective study from July 2021 January 2022, participants HCM healthy control underwent fluorine 18 (18F)-labeled FAPI imaging. activity was quantified as intensity (target-to-background...
Abstract Cardiac hypertrophy has been known as an independent predictor for cardiovascular morbidity and mortality. Molecular mechanisms underlying the development of heart failure remain elusive. Recently, microRNAs (miRs) have established important regulators in cardiac hypertrophy. Here, we reported miR‐221 was up‐regulated both transverse aortic constricted mice patients with hypertrophic cardiomyopathy (HCM). Forced expression by transfection mimics increased myocyte cell size induced...
Sex plays an important role in the clinical expression and prognosis of various cardiovascular diseases. This study was designed to observe effects sex on hypertrophic cardiomyopathy (HCM).A total 621 unrelated patients with HCM without heart failure (460 males) were enrolled from 1999 2011. Compared male patients, at baseline female older diagnosis (49.6±17.2 years vs. 46.7±14.4 years, P = 0.033), had greater frequency left ventricular outflow tract obstruction (72/161, 44.7% 149/460,...
Background— Although mutations of several genes are associated with arrhythmogenic right ventricular cardiomyopathy (ARVC), the exact correlation between genotype and arrhythmia features remains unclear. This study was aimed to examine possible association 9 known ARVC clinical electrophysiological characteristics. Methods Results— Ninety subjects diagnosed who underwent were recruited for screening ARVC-causing genes. A total 53 identified in 57 (63%) subjects. Mutation carriers had more...
Modifier genes contribute to the diverse clinical manifestations of hypertrophic cardiomyopathy (HCM), but are still largely unknown. Muscle ring finger (MuRF) proteins a class muscle-specific ubiquitin E3-ligases that appear modulate cardiac mass and function by regulating ubiquitin-proteasome system. In this study we screened all three members MuRF family, MuRF1, MuRF2 MuRF3, in 594 unrelated HCM patients 307 healthy controls targeted resequencing. Identified rare variants were confirmed...
Background Elevated high‐sensitivity C‐reactive protein (hs CRP ) has been associated with increased risks of adverse outcomes various cardiovascular diseases. The relationship between hs and the prognosis hypertrophic cardiomyopathy remains to be evaluated. Methods Results study used an observational cohort methodology. A total 490 patients were enrolled in Fuwai Hospital from 2001 2011 followed for 3.7±2.0 years. According risk category , subjects high group (>3.0 mg/L) had a higher...
Objectives: The clinical outcomes of hypertrophic cardiomyopathy (HCM) are largely unpredictable. This study aimed to investigate the relationship between atrial fibrillation (AF) and its prognostic implications in Chinese patients with HCM. Methods: From 1999 2011, 654 unrelated HCM were consecutively recruited at Fuwai Hospital. Medical history, including electrocardiographic echocardiographic data, was analyzed. Results: AF documented 158 (24%). During follow-up 4.2 ± 2.8 years,...
Background Hypertrophic cardiomyopathy (HCM) due to mutations in genes encoding sarcomere proteins is most commonly inherited as an autosomal dominant trait. Since nearly 50% of HCM cases occur the absence a family history, recessive inheritance pattern may be involved. Methods A pedigree was identified with suspected transmission HCM. Twenty-six HCM-related were comprehensively screened for proband targeted second generation sequencing, and mutation confirmed bi-directional Sanger...
Background Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a heritable cardiac disease predominantly caused by mutations in desmosomal protein genes. Previous genetic analyses of the Chinese ARVC population are limited to small size and restriction single gene. This study was aimed investigate genotype large series patients with through comprehensively screening nine ARVC-causing Methods A total 100 unrelated 300 age, gender ethnicity matched healthy controls were genetically...
The relationship between a fragmented QRS (fQRS) and clinical outcomes in patients with hypertrophic cardiomyopathy (HCM) remains unclear. This study aimed to investigate the prognostic significance of fQRS HCM.Between 2000 2012, 326 unrelated HCM (72% male mean age 52 years) were included divided into 2 groups: those without fQRS.A total 105/326(32.2%) presented at enrollment. During follow-up 5.3 ± 2.4 years, 33 died, 30 cardiovascular disease (CVD). Cox regression analysis revealed that...
// Yao Wang 1 , Su Wei Yi-Lu Miao Liu Man Shang Qi Zhang 4 Yan-Na Wu Ming-Lin 2, 3 Jun-Qiu Song and Yan-Xia Department of Pharmacology, School Basic Medical Sciences, Tianjin University, 300070, China 2 Section Endocrinology, Medicine, Temple University Philadelphia, PA19140, USA PA 19140, Dermatology, Perelman Pennsylvania, 19104, Correspondence to: Liu, email: liu_yanxia126@126.com Song, song_junqiu@126.com Keywords: microvesicles, ischemia/reperfusion, apoptosis, Bcl-2/Bax, GRP78...