A5103035291- MicroRNA in disease regulation
- Pulmonary Hypertension Research and Treatments
- Bone Metabolism and Diseases
- Venous Thromboembolism Diagnosis and Management
- Neurological Disease Mechanisms and Treatments
- Signaling Pathways in Disease
- Immune cells in cancer
- Autophagy in Disease and Therapy
- Neuroendocrine Tumor Research Advances
- RNA Research and Splicing
- Virus-based gene therapy research
- Ferroptosis and cancer prognosis
- Healthcare Systems and Public Health
- Monoclonal and Polyclonal Antibodies Research
- Phagocytosis and Immune Regulation
- Cancer Cells and Metastasis
- Pancreatic and Hepatic Oncology Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- HER2/EGFR in Cancer Research
- Blood Coagulation and Thrombosis Mechanisms
- Mechanisms of cancer metastasis
- Psoriasis: Treatment and Pathogenesis
- Urological Disorders and Treatments
- Cancer-related Molecular Pathways
- Cholesterol and Lipid Metabolism
Air Force Medical University
2025
Xijing Hospital
2025
Jilin Agricultural University
2025
Fu Wai Hospital
2011-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2009-2024
State Key Laboratory of Cardiovascular Disease
2024
Qiqihar Medical University
2020-2024
Qingdao University
2022-2024
Affiliated Hospital of Qingdao University
2022-2024
Gannan Medical University
2024
<b>Background:</b> Surgical closure of patent ductus arteriosus (PDA) with severe pulmonary arterial hypertension in adults carries higher risk than children. <b>Objectives:</b> To investigate the application self-expandable occluders for transcatheter PDA associated adults, and assessment immediate short-term results. <b>Methods:</b> 29 adult patients (6 men, 23 women) underwent attempted at a mean (standard deviation (SD)) age 31.1 (11.4) years (range 18–58 years) (SD) weight 54.1 (7.1) kg...
Abstract Colorectal cancer (CRC) is the third most common associated with a poor prognosis. Effective targeted therapy alone or in combination for treating advanced CRC remains to be major clinical challenge. Here, we propose therapeutic efficacy and molecular mechanism underlying RC48, FDA-approved anti-HER2 antibody conjugate via cleavable linker microtubule inhibitor monomethyl auristatin E (MMAE), either gemcitabine (GEM) various models of HER2-positive CRC. Our findings demonstrated...
Abstract Cardiac hypertrophy has been known as an independent predictor for cardiovascular morbidity and mortality. Molecular mechanisms underlying the development of heart failure remain elusive. Recently, microRNAs (miRs) have established important regulators in cardiac hypertrophy. Here, we reported miR‐221 was up‐regulated both transverse aortic constricted mice patients with hypertrophic cardiomyopathy (HCM). Forced expression by transfection mimics increased myocyte cell size induced...
Our previous studies demonstrated that inflammation contributes to atherosclerosis through disruption of the low density lipoprotein receptor (LDLr) pathway. However, this effect is overridden by rapamycin, which an inhibitor mammalian target rapamycin (mTOR). This study investigated role mTOR pathway in vivo and vitro. To induce inflammation, we used subcutaneous injection 10% casein apolipoprotein E knockout (ApoE KO) mice lipopolysaccharide stimulation rat vascular smooth muscle cells...
CD44, a transmembrane glycoprotein expressed in variety of cells and tissues, has been implicated tumour metastasis. But the molecular mechanisms CD44-mediated cell metastasis remain to be elucidated. The downregulation CD44 was determined by immunofluorescence. Moreover, motility breast cancer detected wound-healing transwell experiments. Then spontaneous CD44-silenced MDA-MB-231 tested histology with BALB/c nude mice. A positive correlation between Na+/H+ exchanger isoform 1 (NHE1) found...
Mercury, a prevalent heavy metal, negatively impacts oocyte maturation. However, the exact mechanism by which methylmercury chloride (MMC) affects this process remains elusive. The present study found that MMC administration triggered meiotic failure in oocytes disrupting cumulus cell expansion, leading to compromised spindle apparatus and altered chromosomal architecture, are crucial for development. This disruption is characterized abnormal microtubule organization defective chromosome...
The interplay between microbiota and the onset of immune-mediated diseases is increasingly coming to light. However, role tonsillar in cutaneous inflammation remains largely unknown. We aimed determine how influence skin psoriasis uncover underlying molecular mechanisms. Tonsillar samples were collected from 24 healthy controls 28 patients. Microbial community composition was analyzed using 16S rRNA sequencing metagenomic sequencing. Serum levels short-chain fatty acids (SCFAs) measured via...
ABSTRACT Biological agents targeting IL‐17A, such as secukinumab and ixekizumab, are highly effective in treating psoriasis, often achieving low disease activity or remission. However, frequent injections, side effects high costs pose significant challenges. Extending dosing intervals for patients with stable partial response may address these issues while maintaining efficacy, yet standardised dose reduction guidelines remain absent. This study aimed to evaluate the efficacy safety of...
GDF15 (growth-differentiation factor 15) is a novel antihypertrophic which induced in the heart response to pressure overload and plays an important regulatory role process of hypertrophy. In present study, we have investigated relationship between gene variants left ventricular hypertrophy human essential hypertension. A community-based hypertensive population sample 1527 individuals (506 men 1021 women) was genotyped for three genetic variants, including one tag variant −3148C&gt;G...
Purpose Protein kinase plays an essential role in controlling cardiac growth and hypertrophic remodeling. The troponin I-interacting (TNNI3K), a novel specific kinase, is associated with cardiomyocyte hypertrophy. However, the precise function of TNNI3K regulating remodeling has remained controversial. Methods Results In rat model hypertrophy generated by transverse aortic constriction, myocardial expression was significantly increased 1.62 folds (P<0.05) after constriction for 15 days. To...
From November 2022 to February 2023, the Chinese mainland experienced a surge in COVID-19 infection and hospitalization, hospital-based healthcare workers (HCWs) might suffer serious psychological crisis during this period. This study aims assess depressive anxiety symptoms among HCWs of pandemic provide possible reference on protecting mental health future infectious disease outbreaks.A multicenter cross-sectional was carried out from 5 January 9 2023. The PHQ-9 (nine-item Patient Health...
Apoptosis has a critical role in both physiological and pathological processes, therefore probes that enable direct fast visualization for apoptosis vitro vivo have great significance evaluation of therapeutic effects, disease monitoring drug screening. We report here novel apoptotic marker heat shock protein 60 (HSP60)-based imaging probe, P17. In this study, we show P17 can label multiple drug-induced cells vitro, the difference binding intensities between viable by fluorescent is more...
Objective: CD133 is a demonstrated cancer stem cell marker. A small peptide LS7, screened by phage display technique, was identified to specifically target CD133. The purpose of this study develop novel and specific peptide-based PET imaging agent for in colorectal cancer. Methods: LS7 conjugated with 1,4,7,20-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) radiolabeled 68 Ga. cellular uptake assessed vitro. In vivo small-animal PET/CT ex biodistribution evaluations were performed...
uPA (urokinase-plasminogen activator) and its receptor (uPAR) have been implicated in a broad spectrum of pathophysiological processes, including fibrinolysis, proteolysis, inflammation, atherogenesis plaque destabilization, all which are involved the pathogenesis MI (myocardial infarction). We hypothesized that putative functional genetic variation two genes encoding uPAR (PLAU PLAUR respectively) might influence susceptibility to MI. genotyped rs4065 [3'-UTR (untranslated region) *141C>T)...
Abstract Adenovirus early region 4 open reading frame (E4orf4) protein is a novel cell death factor that selectively induces apoptosis in cancer cells. This study evaluated tumor inhibitory effects of made by fusion E4orf4 and human epidermal growth (EGF). EGF was used to ensure the selective targeting receptor (EGFR)‐overexpressing Results showed EGF‐E4orf4 stimulated EGFR phosphorylation time‐ dose‐dependent manner. Confocal microscopy analysis both could be internalized via but they had...
Postmenopausal osteoporosis (PMOP), the most frequent bone-related disease, is characterized by bone loss and fragile fractures, which related to low density (BMD). This study aimed illustrate expression mechanism of miR-33a-3p in osteoporosis.TargetScan luciferase reporter assay were applied for verifying relevance between IGF2. Levels miR-33a-3p, IGF2, Runx2, ALP Osterix checked using RT-qPCR western blotting. hBMSCs proliferation, apoptosis activity analyzed MTT, flow cytometry (FCM)...
The development of respiratory medicine has evolved from the prevention and treatment tuberculosis in 1950 s to care chronic obstructive pulmonary disease corpulmonale 1970 s. In past 20 years, it further advanced into integration (PM) critical (CC), becoming a dominant form global disciplines medicine. subspecialty training system (PCCM) is decisive measure ensure standardized medicine, medical intensive unit (MICU) most important clinical practice field for China, which plays crucial role...
Embryo vitrification is a standard procedure in assisted reproductive technology. Previous studies have shown that frozen embryo transfer associated with an elevated risk of adverse maternal and neonatal outcomes. This study aimed to explore the effects mouse blastocyst on phenotype vitrified-warmed blastocysts, their intrauterine postnatal development, long-term metabolic health derived offspring. The blastocysts (IVF + VT group) exhibited reduced mitochondrial activity, increased apoptotic...
Abstract Background: Triple-negative breast cancer (TNBC) accounts for 10-15% of all cases. A major area innovation in TNBC is identifying potential treatment targets, especially cells which survive chemotherapy. Our previous study showed that displayed deregulated kinase-dependent signaling cascades, and uniquely divergent phospho-circuits could be distinguished between vs non-TNBC cell lines [2014 SABCS abstract 1672, poster P2-05-09]. We further hypothesized specific dysfunctional...