A5100317726- Birth, Development, and Health
- Pregnancy and preeclampsia studies
- Gestational Diabetes Research and Management
- Psoriasis: Treatment and Pathogenesis
- Nutritional Studies and Diet
- Cancer, Stress, Anesthesia, and Immune Response
- Fatty Acid Research and Health
- Tuberculosis Research and Epidemiology
- Antioxidant Activity and Oxidative Stress
- Advanced Breast Cancer Therapies
- Bone Tissue Engineering Materials
- Systemic Lupus Erythematosus Research
- Atherosclerosis and Cardiovascular Diseases
- Peptidase Inhibition and Analysis
- Cancer Cells and Metastasis
- Bone health and treatments
- Wound Healing and Treatments
- Cardiovascular Health and Disease Prevention
- Adipokines, Inflammation, and Metabolic Diseases
- Pelvic floor disorders treatments
- Chemotherapy-induced cardiotoxicity and mitigation
- Vitamin D Research Studies
- Enhanced Recovery After Surgery
- Dermatology and Skin Diseases
- COVID-19 Clinical Research Studies
Xijing Hospital
2023-2025
Air Force Medical University
2023-2025
First Affiliated Hospital of Zhengzhou University
2017-2024
Chengdu University of Technology
2024
Nanjing Agricultural University
2021-2024
Henan Forestry Vocational College
2024
Jinan Maternity And Care Hospital
2024
Animal Science Research Institute
2023
Peking University
2019-2023
Peking University People's Hospital
2022-2023
This study aimed to determine the levels of health-related behaviours (physical activity, screen exposure and sleep status) among Chinese students from primary, secondary high schools during pandemic COVID-19, as well their changes compared with status before pandemic. A cross-sectional online survey 10,933 was conducted 10 in Guangzhou, China, between 8th 15th March, 2020. After getting informed consent student's caregivers, an questionnaire designed used obtain time spending on 3 months...
Rationale: Bone is one of the most common metastatic sites breast cancer. CD137 (4-1BB), a member tumor necrosis factor (TNF) receptor superfamily, mainly expressed in activated leukocytes. Previous study demonstrates effect CD137-CD137L bidirectional signaling pathway on RANKL-mediated osteoclastogenesis. However, role bone metastasis cancer needs further study. Methods: Stable monocyte/macrophage cell lines with Cd137 overexpression and silencing were established. Western blot, real-time...
Legumain is a member of the asparaginyl endopeptidase family that over-expressed in response to hypoxic stress on mammary adenocarcinoma, colorectal cancer, proliferating endothelial cells, and tumor-associated macrophages (TAMs). Here, we demonstrate elevated expression legumain ovarian cancer by proteomic approach using isobaric tags for relative absolute quantification (iTRAQ) followed liquid chromatography-mass spectrometry (LC-MS/MS). To investigate relationship between development,...
Wound treatment is a long-lasting clinical issue. Poor angiogenesis leading to delayed wound closure causes huge challenges for healing. Functional electrospun membranes have been established as an efficient strategy promote recovery by protecting and improving vascular regeneration. Here, we aimed investigate the effect of tazarotene, active drug angiogenesis, loaded in aligned nanofibrous barrier on soft tissue wound. This membrane was arranged single direction, tazarotene could be...
Background: The Guangzhou Nutrition and Health Study (GNHS) aims to assess the determinants of metabolic disease in nutritional aspects, as well other environmental genetic factors, explore possible biomarkers mechanisms with multi-omics integration.
Abstract TGF-β-induced factor homeobox 2 (TGIF2) is a transcription regulator that plays essential roles in the regulation of development and cell fate decisions. Aberrant expression TGIF family proteins has been observed several cancers, including ovarian, esophageal, colorectal cancers. Here, we report TGIF2 mediates EGFR–RAS–ERK signaling pathway to enhance stemness lung adenocarcinoma (LUAD) cells and, therefore, promote progression metastasis LUAD. We found high was closely correlated...
Infectious cutaneous wounds are a thorny clinical problem. The microenvironment of the infectious wound is complicated and changes at different healing stages. Traditional treatments either have single effect such as anti-inflammation, antibacteria, or angiogenesis simple mixture several functions. They fail to deal with change physiological process, leading unsatisfactory outcomes. Herein, we designed logic-based smart nanoplatform (named ZEM), aiming self-monitor accordingly react fitting...
Background Although it is well established that a higher body weight protective against osteoporosis, the effects of fat and distribution on bone mineral density (BMD) after adjustment for remains uncertain. Objective To examine relationship between BMD beyond its weight-bearing effect in middle-aged Chinese adults. Method The study had community-based cross-sectional design involved 1,767 women 698 men aged 50–75 years. lumbar spine, total hip, whole body, mass (FM) percentage (%FM)...
Elevated glucocorticoid (GC) activity may be involved in the development of metabolic syndrome. Tissue GC exposure is determined by tissue-specific GC-activating enzyme 11β-hydroxysteriod dehydrogenase type 1 (11β-HSD1) and GC-inactivating 5α-reductase (5αR1), as well 5β-reductase (5βR). Our aim was to study effects neonatal overfeeding induced small litter rearing on expression GC-regulating enzymes adipose tissue and/or liver obesity-related disturbances during development. Male...
Abstract It is indicated that lipids profiles are associated with carotid plaque and Atherosclerosis. However, studies about the relationship between serum lipid composition in Chinese Population limited. We conducted a cross-sectional study among 3,214 participants January 2015 December 2017 China, to investigate association various prevalence of plaque. Logistic regression model was used plasma odds Analysis covariance (ANCOVA) compare mean different number artery plaques. HDL-C, Non-HDL-C...
Rationale: Psychological stress has been linked to cancer development and resistance therapy by many epidemiological clinical studies. Stress-induced immunosuppressive microenvironment hormones, in particular glucocorticoids, extensively studied. However, the impacts of other stress-related neurotransmitters, such as serotonin (5-hydroxytryptamine, 5-HT), on just start be revealed. Here, we aimed identify novel neurotransmitters involved stress-induced growth dissemination ovarian (OC)...
ABSTRACT Biological agents targeting IL‐17A, such as secukinumab and ixekizumab, are highly effective in treating psoriasis, often achieving low disease activity or remission. However, frequent injections, side effects high costs pose significant challenges. Extending dosing intervals for patients with stable partial response may address these issues while maintaining efficacy, yet standardised dose reduction guidelines remain absent. This study aimed to evaluate the efficacy safety of...
Abstract Maternal diet is an important potential factor associated with the risk of preeclampsia. However, it unclear whether adherence to a Dietary Approaches Stop Hypertension (DASH)-style can reduce development To examine association, we conducted hospital-based case-control study at First Affiliated Hospital Zhengzhou University, China. A total 449 cases preeclampsia and controls were studied. information was collected using validated food frequency questionnaire (FFQ). DASH scores...
There is little known about the global burden of CVD attributable to ambient PM2.5 (referred as hereinafter) and its secular trend across different regions countries. We aimed evaluate spatiotemporal trends in at global, regional national levels from 1990 2019. Data on including mortality disability adjusted life years (DALYs) 2019 were extracted Global Burden Disease Study Cases, age-standardized rate (ASMR) DALYs (ASDR) estimated by age, sex sociodemographic index (SDI). Estimated annual...
Obesity is becoming a worldwide pandemic. Interfacial engineering of food lipid expected to inhibit diet-induced obesity without damage the eating enjoyment brought by high-fat diets. Unfortunately, this strategy has not been achieved yet. After screening different plant proteins, bromelain and papain were found form wormlike long-straight protein fibrils, respectively. The conversion amyloid-like fibrils was demonstrated in fibrillation bromelain. Using oil-in-water high internal phase...
H5N6 highly pathogenic avian influenza is a zoonotic disease that causes recurring endemics in East Asia. To date, at least 155 outbreaks have been reported China, including 15 human infection cases. The repeated increase the concern viruses may spill over to humans and cause pandemic. In February, 2016, some peafowls breeding farm suffered from contagious disease. Based on post-mortem examination, RT-PCR detection, virus isolation, we confirmed was causative agent, which named as A/Pavo...