A5062870581- DNA Repair Mechanisms
- DNA and Nucleic Acid Chemistry
- RNA Interference and Gene Delivery
- RNA modifications and cancer
- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Nutrition and Health in Aging
- RNA Research and Splicing
- Advanced Radiotherapy Techniques
- Head and Neck Cancer Studies
- Pregnancy and Medication Impact
- Nutritional Studies and Diet
- COVID-19 Clinical Research Studies
- PARP inhibition in cancer therapy
- Smoking Behavior and Cessation
- Esophageal and GI Pathology
- Cancer, Hypoxia, and Metabolism
- COVID-19 and Mental Health
- Esophageal Cancer Research and Treatment
- Peptidase Inhibition and Analysis
- Glioma Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- Dermatological and COVID-19 studies
- Advanced Electron Microscopy Techniques and Applications
- Liver Diseases and Immunity
Central South University
2016-2025
Hunan Cancer Hospital
2016-2025
Xiangya Hospital Central South University
2019-2024
Taiyuan University of Technology
2022-2023
Zhengzhou University
2019-2021
Zhoukou City Academy of Agricultural Sciences
2021
Henan Cancer Hospital
2019
First Affiliated Hospital of Zhengzhou University
2019
Translational Research in Oncology
2016
Highlights•Radioresistant cancer cells reprogram metabolic flux toward glutamine anabolism•GS promotes cellular nucleotide synthesis for efficient DNA repair•High expression of GS facilitates growth under radiation stress•GS is transcriptionally regulated by STAT5SummaryRadiation resistance a critical problem in radiotherapy cancer. Radiation kills tumor mainly through causing damage. Thus, efficiency damage repair one the most important factors that limits efficacy. Glutamine...
Malnutrition is the most common complication of patients with esophageal cancer and can lead to poor prognosis death. Good nutritional status has been shown help improve patient outcomes reduce complications. In absence specific evidence on effect nutrition in cancer, purpose this study was investigate whole-course management complications chemoradiotherapy through a randomized controlled trial. A total 96 treated concurrent chemoradiation were an intervention group (treated from Nutrition...
DEAD-box RNA helicases belong to a large group of RNA-processing factors and play vital roles unwinding helices in ribosomal biogenesis. Emerging evidence indicates that are associated with genome stability, yet the mechanisms behind this association remain poorly understood. In study, we performed comprehensive analysis using multiplatform proteogenomic databases. More than 50% (28/49) detected were highly expressed multiple tumor tissues, more 60% (17/28) tumor-associated members directly...
Nimotuzumab is a blocking monoclonal antibody against epidermal growth factor receptor (EGFR). However, little known about the safety and preliminary efficacy of nimotuzumab combined with concurrent chemoradiotherapy in locally advanced NPC patients. A total 42 patients diagnosed between 2011 2013 were enrolled. Our results demonstrated 38 had complete response (90.5%), 4 partial (9.5%). And no progressive disease at early treatment evaluation, giving an ORR 100%. The 2-year local...
The global outbreak of the coronavirus disease 2019 (COVID-19) pandemic occurred in late and early 2020. factors that influence severity should be clinical concern. Existing findings on effects smoking COVID-19 are also controversial need to confirmed by further research. In addition, alcohol consumption betel quid (BQ) chewing unclear. aim this study was examine demographic characteristics patients smoking, drinking, BQ chewing, underlying diseases COVID-19. A retrospective conducted 91...
1. University of Washington, Institute for Health Metrics and Evaluation. Global Burden Disease Study 2019 (GBD 2019) Smoking Tobacco Use Prevalence 1990-2019. 2021. Accessed March 10, 2023. https://ghdx.healthdata.org/re... Google Scholar
Abstract Maternal diet is an important potential factor associated with the risk of preeclampsia. However, it unclear whether adherence to a Dietary Approaches Stop Hypertension (DASH)-style can reduce development To examine association, we conducted hospital-based case-control study at First Affiliated Hospital Zhengzhou University, China. A total 449 cases preeclampsia and controls were studied. information was collected using validated food frequency questionnaire (FFQ). DASH scores...
Abstract Introduction The effect of diffusion-weighted magnetic resonance imaging (DWI)-guided dose-painting intensity-modulated radiation therapy (DP-IMRT) on locally advanced recurrent nasopharyngeal carcinoma (NPC) remains unclear. This study aimed to compare the outcomes and toxicities DWI-guided DP-IMRT in patients with NPC. Methods In this prospective trial, 150 NPC were randomly assigned (1:1) receive reirradiation (DWI group, n = 75) or conventional MRI-based IMRT (MRI 75). DWI gross...
Resistance to radiation of cancer cells can be either intrinsic or acquired, leading treatment failure. In response DNA damage caused by IR, are arrested in cell cycle showing limited proliferation and increased apoptosis. However, radiation-resistant able overcome the block proceed proliferation, for which detailed mechanism remains elucidated. present study, we showed that radioresistant exhibited a recoverable G2/M phase during prolonged manifested lower apoptosis rate more colony...
Tumor acquired radioresistance remains as the major limit in cancer radiotherapy (RT). Rab25, a receptor recycling protein, has been reported to be enhanced tumors with aggressive phenotype and chemotherapy resistance. In this study, elevated Rab25 expression was identified an array of radioresistant human cell lines, vivo xenograft tumors. Clinical investigation confirmed that also associated worse prognosis patients lung adenocarcinoma (LUAD) nasopharyngeal carcinoma (NPC). Enhanced...
Purpose: The aim of the study was to detect expression Sox10 in human nasopharyngeal carcinoma (NPC) and investigate relationship between its clinicopathological characteristics NPC patients. Patients methods: Tumor specimens (n=105) were retrospectively collected from patients with diagnosed 2004 2005 who presented at Hunan Cancer Hospital. Immunohistochemistry analyses performed characterize NPC. Kaplan–Meier survival Cox regression employed evaluate prognosis 105 Results: results showed...
Small cell lung cancer (SCLC) accounts for approximately 10-15% of all cancers. No significant improvement has been made patients with SCLC in the past several decades. The main progresses were thoracic radiation and prophylactic cranial irradiation (PCI) that improved patient survival rate. For limited disease good performance status (PS), concurrent chemoradiotherapy (CCRT) followed by PCI should be considered. extensive disease, combination etoposide platinum-based chemotherapy remains...
Objective: The aim of our case-control study was to find the influence lifestyle and comorbidities on COVID-19 susceptibility, identify risk factors protective factors, ways encourage people adopt a healthy lifestyle. Methods: Patients with were matched non-COVID-19 participants in ratio 1:2. Univariate analysis performed using chi-square test, multivariate conditional logistic regression. Results: Multivariate regression found that alcohol consumption (AC) bland diet increased COVID-19,...
Background and objectives To evaluate the effect of oral nutritional supplements (ONS) on community elderly people with malnutrition or risk malnutrition. Methods study design A single arm intervention trial for 3 months was conducted. Whole nutrient powder given to all participants. Dietary intakes were measured by 3-day diet record. Nutritional status evaluated using body weight, mass index (BMI), calf circumference (CC), Mini Assessment Short-Form (MNA-SF) scores. Muscle bioimpedance...
Background . Many studies have demonstrated that a higher radiotherapy dose is associated with improved outcomes in non-small-cell lung cancer (NSCLC). We performed dosimetric planning study to assess the feasibility of intensity-modulated radiation therapy (IMRT) simultaneous integrated boost (SIB) locally advanced NSCLC. Methods enrolled twenty patients. Five different plans were generated for each patient. All prescribed 60 Gy tumor volume (PTV). In three SIB groups, was 69 Gy, 75 and 81...
Chromosomal instability (CIN) covers approximately 65 to 70% of colorectal cancer patients and plays an essential role in progression. However, the molecular features therapeutic strategies related those are still controversial. R-loop binding proteins (RLBPs) exert significant roles transcription replication. Here, integrative proteogenomic analysis identified two RLBPs subtypes correlated with distinct prognoses. Cluster I (CI), represented by high expression RLBPs, was associated CIN...
Background and Objectives: Malnutrition is implicated as a key modifiable risk factor for sarcopenia. As such, dietary pattern analysis, rather than an analysis of single food items or nutrients, may provide insights into the comprehensive contribution diet nutrition to Accordingly, aim this study was evaluate relationships between main patterns Methods Study Design: A total 591 participants aged over 40 years were included in cross-sectional study. validated food-frequency questionnaire...
1. Chinese Center for Disease Control and Prevention. Summary of 2018 China Adult Tobacco Survey. Survey in Chinese. Prevention; 2019. Accessed September 22, 2022. https://www.chinacdc.cn/jkzt/s... Google Scholar
The effectiveness of radiotherapy in colorectal cancer (CRC) relies on its ability to induce cell death via the generation reactive oxygen species (ROS). However, genes responsible for mitigating oxidative stress can impede radiotherapy's efficacy. In this study, we elucidate a significant association between nucleolar protein Fibrillarin (FBL) and response CRC tumors. Our findings reveal elevated expression FBL cancer, which positively correlates with levels. Mechanistically, demonstrates...