A5100697806- Colorectal Cancer Surgical Treatments
- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Screening and Detection
- Cancer-related molecular mechanisms research
- Colorectal and Anal Carcinomas
- Reproductive Biology and Fertility
- Colorectal Cancer Treatments and Studies
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Neuroendocrine Tumor Research Advances
- Pluripotent Stem Cells Research
- Radiomics and Machine Learning in Medical Imaging
- Cancer Cells and Metastasis
- Sentiment Analysis and Opinion Mining
- Epigenetics and DNA Methylation
- Plant tissue culture and regeneration
- Cancer Immunotherapy and Biomarkers
- Hepatocellular Carcinoma Treatment and Prognosis
- Angiogenesis and VEGF in Cancer
- Gastrointestinal Tumor Research and Treatment
- Genetic factors in colorectal cancer
Xiangya Hospital Central South University
2016-2025
Central South University
2015-2025
Jinzhou Medical University
2016-2024
Wuhan University of Technology
2010-2024
Shaanxi University of Chinese Medicine
2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2014-2024
Chongqing Medical University
2014-2024
North University of China
2024
East China Normal University
2024
Jinan City People's Hospital
2023
Background: Conventional methods for predicting treatment response to neoadjuvant chemoradiotherapy (nCRT) in patients with locally advanced rectal cancer (LARC) are limited. Methods: This study retrospectively recruited 134 LARC who underwent standard nCRT followed by total mesorectal excision surgery our institution. Based on pre-operative axial T2-weighted images, machine learning radiomics was performed. A receiver operating characteristic (ROC) curve performed test the efficiencies of...
Abstract Background Total mesorectal excision following neoadjuvant chemoradiotherapy (nCRT) is recommended in the latest treatment of locally advanced rectal cancer (LARC). Objective To predict whether patients with LARC can achieve pathologic complete response (pCR), comparing MRI‐based radiomics between before and after radiotherapy (nRT) was performed. Methods One hundred sixty‐five features axial T2‐weighted images were obtained quantitatively from Imaging Biomarker Explorer Software....
Colorectal cancer (CRC) is a prevalent malignancy worldwide. The development of genome sequencing technology has allowed the discovery that epigenetic regulation might play critical role in CRC tumorigenesis. In present study, we found long noncoding RNA (lncRNA) SNHG4 was dramatically increased tissue samples and cell lines based on both publicly available experimental data. knockdown suppressed viability colony formation capacity cells. expression CDK1 considerably cells had positive...
The aim of this study was to analyse the landscape publications on rectal cancer (RC) over past 25 years by machine learning and semantic analysis.Publications indexed in PubMed under Medical Subject Headings (MeSH) term 'Rectal Neoplasms' from 1994 2018 were downloaded September 2019. R Python used extract publication date, MeSH terms abstract metadata each for bibliometric assessment. Latent Dirichlet allocation applied text articles' abstracts identify more specific research topics....
The time of pronuclear formation in vivo-matured oocytes was examined. Maturation-promoting factor (MPF) activity enucleated and electrically activated checked by assessment nuclear envelope breakdown (NEBD) fused blastomeres. effect stage the cell cycle donor cells recipient on DNA synthesis development reconstructed embryos studied. MPF declined rapidly to approximately 63.2% at 1 h, 9.7% 5 level which NEBD cannot occur 7 h postactivation. All blastomeres that were cytoplasm activation...
Previous studies demonstrated that several inflammation-based hematological indices are closely related to various malignancies, including colorectal cancer (CRC). In this study, the prognostic value of markers, a combination index termed coNLR-PDW, comprising preoperative neutrophil-to-lymphocyte ratio (NLR) and platelet distribution width (PDW), was evaluated in 206 patients with non-metastatic CRC treated surgery at single medical center. The association patient demographics, blood...
The incidence of colorectal cancer in patients younger than 50 years has been increasing recent years.Develop and validate prognostic nomograms predicting overall survival (OS) cancer-specific (CSS) for early-onset locally advanced colon (EOLACC) based on the Surveillance, Epidemiology, End Results (SEER) database.The entire cohort comprised 13,755 with EOLACC. nomogram OS EOLACC displayed that T stage contributed most to prognosis, followed by N stage, regional nodes examined (RNE) surgery....
Pancreatic cancer is one of the most lethal human malignancies. Gemcitabine widely used to treat pancreatic cancer, and resistance chemotherapy major difficulty in treating disease. N6-methyladenosine (m6A) modification, which regulates RNA splicing, stability, translocation, translation, plays critical roles physiological pathological processes. METTL14, an m6A Lmethyltransferase, was found deregulated multiple types. However, its role gemcitabine remains elusive.The mRNA protein level...
Previous studies reported that Follistatin-like 3 (FSTL3) is abundantly expressed in several solid tumors and participate the regulation of cell metabolism. However, clinico-pathological significance, biological role molecular mechanism FSTL3 colorectal cancer (CRC) still unclear. Here we report expression level colon specimens was significantly higher, compared to normal tissue interestingly, related lymph node metastasis, tumor stage, size, intravascular emboli (IVE). As an upstream event,...
N6-methyladenosine (m6A) modifications of RNAs are involved in various aspects colorectal carcinogenesis via regulation mRNA stability, splicing, and translation. KIAA1429, an m6A methyltransferase, was found deregulated multiple cancer types. However, its role remains elusive. By analyzing TCGA GEPIA database, we that KIAA1429 highly expressed. In addition, used immunohistochemistry, western blotting, QRT-PCR to detect the expression samples cell lines, overexpressed sample line....
Although cisplatin is frequently used to treat gastric cancer, the resistance main obstacle for effective treatment. mRNA modification, N6-methyladenosine (m6A), involved in tumorigenesis of many types cancer. As one largest m6A methyltransferase complex components, KIAA1429 bridges catalytic such as METTL3. In was reported promote cell proliferation. However, whether cancer remains unclear. Here, we generated resistant lines, and compared content between cells wild type cells. The well...
In this study, we prepared new lignin-based pH-responsive nanoparticles (LG-M(N)-PEG NPs) and their conjugates (LG-M(N-DOX)-PEG by using polyethylene glycol (PEG), doxorubicin (DOX), alkaline lignin. these NPs, the PEG chains were conjugated to lignin an UV irradiated thiol–ene click reaction. The hydrazine β-thiopropionate bonds in NPs could conduct pH-triggered release of both DOX at acidic pH tumor cells. Results showed that LG-M(N-DOX)-PEG had a moderate particle size (48.3 ± 3.2 nm),...
Objective Pancreatic ductal adenocarcinoma (PDAC) is characterized by a low survival rate and limited responsiveness to current therapies. The role of hypoxia in the tumor microenvironment critical, influencing progression therapy resistance. aim this study was implement complex dynamics hypoxic PDAC hypoxia-related prognosis model. Methods We utilized single-cell RNA sequencing (scRNA-seq) data integrated it with TCGA-PAAD database identify hypoxia-responsive macrophage subsets related...
Neuron navigator 2 (NAV2) encodes a member of the neuron gene family, which plays role in tumorigenesis and cell migration. However, prognostic value NAV2 expression colorectal cancer (CRC) patients potential pathway through promotes migration invasion CRC lines is poorly understood. The level was detected tissues from two different cohorts by immunohistochemistry, qRT-PCR Western blotting; correlation between clinicopathological characters analyzed, analyzed using Cox regression model. with...
The postoperative survival of patients with stage III colorectal cancer (CRC) various obviously. We sought to develop novel nomograms for predicting the these after radical surgery and chemotherapy. A total 620 consecutive CRC who underwent curative resection chemotherapy between January 2009 December 2015 were retrospectively collected randomly allocated training (n = 372) or validation cohort 248). Clinicopathological factors analyzed. On basis data from 372 in set, predictive overall (OS)...
Lung cancer is the primary cause of cancer‑associated mortality in men and women worldwide. Increasing evidence indicates that abnormal microRNA (miRNA) expression contributes to carcinogenesis progression multiple human cancers, including non‑small cell lung (NSCLC). Therefore, miRNAs exhibit potential act as biomarkers for diagnosis, treatment prognosis malignancies. miRNA‑661 (miR‑661) has previously been demonstrated be important development various types. However, levels, functions...
There is no conclusion about the most important contributor to upswing of locally advanced colorectal cancer (LACRC) survival.Data from Surveillance, Epidemiology, and End Results (SEER) database was extracted identify adenocarcinoma patients at stage II III diagnosed in two periods 1989-1990 2009-2010. The statistical methods included Pearson's chi-squared test, log-rank Cox regression model propensity score matching.The showed that hazard ratio (HR) non-surgery dropped 11.529 3.469 right...
Abstract Background Colorectal cancer (CRC) is the most prevalent malignant tumor of digestive system globally, posing a significant threat to human health and quality life. Recent studies have established associations between gut microbiota immune cells with CRC; however, mechanisms by which influence development progression CRC through mediators remain poorly understood. Methods We conducted two-sample, bidirectional Mendelian randomization analysis. utilized 731 cell types 473 microbial...
AIM:To investigate the targeted inhibition of proliferation and migration SW620 human colon cancer cells by upregulating miRNA-145 (miR-145). METHODS:Forty-five samples tissues 45 normal control were obtained from biological database First Affiliated Hospital Liaoning Medical University.We performed quantitative analysis miR-145 N-ras expression in tissues; reverse transcriptase polymerase chain reaction colonic epithelial cells; construction lentiviral vector determination transduced with...