A5102008737- Microplastics and Plastic Pollution
- Nutrition and Health in Aging
- Dialysis and Renal Disease Management
- biodegradable polymer synthesis and properties
- Industrial Vision Systems and Defect Detection
- Cancer Cells and Metastasis
- Surgical Simulation and Training
- Environmental Impact and Sustainability
- Impact of AI and Big Data on Business and Society
- Additive Manufacturing and 3D Printing Technologies
- Traditional Chinese Medicine Analysis
- Chemokine receptors and signaling
- Recycling and Waste Management Techniques
- Advances in Cucurbitaceae Research
- Genomics and Chromatin Dynamics
- Virus-based gene therapy research
- Anatomy and Medical Technology
- Nutritional Studies and Diet
- RNA modifications and cancer
- interferon and immune responses
- Nanoplatforms for cancer theranostics
- Stroke Rehabilitation and Recovery
- Ferroelectric and Negative Capacitance Devices
- Cancer-related molecular mechanisms research
- Curcumin's Biomedical Applications
Sun Yat-sen University
2015-2025
Sun Yat-sen University Cancer Center
2023-2025
Central South University of Forestry and Technology
2021-2025
Central South University
2021-2025
National Vaccine and Serum Institute
2022-2025
Hefei University of Technology
2024
Nanjing University of Finance and Economics
2024
China Agricultural University
2024
Ministry of Agriculture and Rural Affairs
2024
State Key Laboratory of Optoelectronic Materials and Technology
2024
Cancer‐associated fibroblasts (CAFs) play a key role in orchestrating the tumor malignant biological properties within microenvironment and evidences demonstrate that CAFs are critical regulator of tumoral immunosuppression T cell response. However, functions regulation expression programmed death‐ligand 1 (PD‐L1) melanoma colorectal carcinoma (CRC) not completely understood. Herein, by scrutinizing α‐SMA PD‐L1 CRC tissues, we found was positive correlated with expression. Further analyses...
Pumpkin seed oil was obtained from three extraction methods, namely Soxhlet (SE), cold-pressed (CPE), and aqueous enzymatic (AEE).
While immunotherapy has emerged as a promising strategy to treat melanoma, the limited availability of immunotherapeutic agents in tumors due immunosuppressive tumor microenvironment dampens its efficacy. Pyroptosis is gasdermin-mediated programmed necrosis that triggers inflammatory and enhances efficacy immunotherapy. Here, we prove CXCR4 antagonist T22 peptide specially targeted became internalized into CXCR4+ melanoma cells. Then report self-assembling nanotoxin can be used...
Fibroblasts become cancer-associated fibroblasts (CAFs) in the tumor microenvironment after activation by transforming growth factor-β (TGF-β) and are critically involved cancer progression. However, it is unknown whether TGF superfamily member Nodal, which expressed various tumors but not normal adult tissue, influences fibroblast to CAF conversion. Here, we report that Nodal has a positive correlation with α-smooth muscle actin (α-SMA) clinical melanoma colorectal (CRC) tissues. We show...
Oil was extracted from melon seeds with three different methods (Soxhlet, cold-pressed, aqueous enzymatic extraction), aiming to evaluate its physicochemical properties and oxidative stability. The seed oil contained high levels of linoleic acid (53.6% - 70.8%, w/w), squalene (101.1 164.7 mg/100 g), β-sitosterol (119.5 291.9 g). Results showed that the choice extraction method did not alter fatty composition, but impacted on properties, content bioactive compounds stability oil....
Early detection and diagnosis of cancers is extremely beneficial for improving the survival rate cancer patients molecular imaging techniques are believed to be relevant offering clinical solutions. Towards early detection, we developed a primary animal colorectal model constructed tumor-specific probe by using biocompatible NaGdF4:Yb,Er@NaGdF4 upconversion luminescent NPs establishing sensitive tumor method. The model, which can better mimic human cancer, was built upon continual...
Purpose Cancer-associated fibroblasts (CAFs) activated by cancer cells has a central role in development and malignant biological behavior colorectal (CRC). Adult do not express Snail, but Snail-positive are discovered the stroma of CRC reported to be key chemoresistance. However, reciprocal effect CAFs expressed Snail chemoresistance on underlying molecular mechanisms fully characterized. Materials Methods Snail-overexpressed 3T3 stable cell lines were generated lipidosome CT26 mixed with...
Pancreatic cancer is one of the most lethal human malignancies. Gemcitabine widely used to treat pancreatic cancer, and resistance chemotherapy major difficulty in treating disease. N6-methyladenosine (m6A) modification, which regulates RNA splicing, stability, translocation, translation, plays critical roles physiological pathological processes. METTL14, an m6A Lmethyltransferase, was found deregulated multiple types. However, its role gemcitabine remains elusive.The mRNA protein level...
Robot-assisted minimally invasive surgery requires accurate segmentation for surgical instruments in order to guide robots on tracking the target instruments. Nevertheless, it is difficult perform surgical-instrument semantic unknown scenes with extremely insufficient intra-scene data, despite of attempts general tasks. To address this issue, we propose a cross-scene approach medical using structural similarity based partial activation networks paper. The proposed includes main branch...
Crop residue cover plays a key role in the protection of black soil by covering non-growing season against wind erosion and chopping for returning to increase organic matter future. Although there are some studies that have mapped crop coverage remote sensing technique, results mainly on small scale, limiting generalizability results. In this study, we present novel corn (CRC) dataset Northeast China spanning years 2013-2021. The aim our is provide basis describe monitor CRC protection....
The "von Neumann bottleneck" is a formidable challenge in conventional computing, driving exploration into artificial synapses. Organic semiconductor materials show promise but are hindered by issues such as poor adhesion and high elastic modulus. Here, we combine polyisoindigo-bithiophene (PIID-2T) with grafted poly(dimethylsiloxane) (PDMS) to synthesize the triblock-conjugated polymer (PIID-2T-PDMS). exhibited substantial enhancements (4.8-68.8 nN) reductions modulus (1.6-0.58 GPa) while...
Expression of the Neuropilin-1 (NRP1) is reported in malignant cells multiple human tumor types represented as a marker. Targeting NRP1 with peptide, CK3, used for molecular imaging, raising question therapeutic potential CK2, peptide CK3 backbone which enhanced targeting and enrichment properties. The capacity CK2 was detected by IncuCyte, flow cytometry animal living imaging. To enhance its efficacy, we developed self-assembling nanoparticles Fmoc-Gffy-AP-CK2, incorporating protective...
Sarcopenia is common and contributes to a high risk of mortality among general population. There no consensus regarding the cut-off values for sarcopenia in terms chronic kidney disease patients. This study aimed explore validate points handgrip strength (HGS) lean mass index (LMI) estimating peritoneal dialysis (PD) patients.This single-center prospective cohort enrolled 1089 incident PD patients between October 2002 July 2019. All were followed until death, transfer hemodialysis, receiving...
Abstract Higher fibre intake reduced all-cause and cardiovascular mortality among healthy population, but such data in dialysis patients are limited. We aimed to examine these associations on peritoneal (PD). This single-centre prospective cohort study enrolled 881 incident PD between October 2002 August 2014. All were followed until death, transfer haemodialysis, renal transplantation or being censored June 2018. Demographic collected at baseline. Biochemical, dietary nutrition examined...
Aberrant expression of nuclear transporters and deregulated subcellular localization their cargo proteins are emerging as drivers therapeutic targets cancer. Here, we present evidence that the exporter exportin-6 its profilin-1 constitute a functionally important frequently axis in Exportin-6 upregulation occurs numerous cancer types is associated with poor patient survival. Reducing level breast cells triggers antitumor effects by accumulating profilin-1. Mechanistically, interacts...
Neutrophils are heterogeneous and plastic, with the ability to polarize from antitumour protumour phenotype modulate tumour microenvironment components. While some advances have been made, neutrophil-targeting therapy remains underexplored. Activation of formyl peptide receptors (FPRs) by formylated peptides is needed for local control infection through recruitment activated neutrophils while potential contribution activity Here, we demonstrate that can be harnessed suppress growth action...