A5100773102- Cancer Cells and Metastasis
- Cytokine Signaling Pathways and Interactions
- Sarcoma Diagnosis and Treatment
- Medicinal Plant Pharmacodynamics Research
- Neuroblastoma Research and Treatments
- Management of metastatic bone disease
- Cancer Mechanisms and Therapy
- Cancer, Hypoxia, and Metabolism
- Mechanisms of cancer metastasis
- Peptidase Inhibition and Analysis
- Macrophage Migration Inhibitory Factor
- Immunotherapy and Immune Responses
- Fibroblast Growth Factor Research
- Pharmacogenetics and Drug Metabolism
- Quinazolinone synthesis and applications
- RNA Interference and Gene Delivery
- Metastasis and carcinoma case studies
- Cancer-related molecular mechanisms research
- Cancer, Stress, Anesthesia, and Immune Response
- Orthopaedic implants and arthroplasty
- Cellular Mechanics and Interactions
- interferon and immune responses
- Nanoplatforms for cancer theranostics
- Shoulder Injury and Treatment
- Ocular Diseases and Behçet’s Syndrome
Chinese Academy of Medical Sciences Dermatology Hospital
2021-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2025
Nanjing Medical University
2025
Shanghai First People's Hospital
2016-2024
Shanghai Jiao Tong University
2011-2024
Sun Yat-sen University
2013-2024
Shanghai Cancer Institute
2019-2022
Beihua University
2020
Yangpu Hospital of Tongji University
2016-2018
Nanjing University of Information Science and Technology
2016
Chronic inflammation-promoted metastasis has been considered as a major challenge in cancer therapy. Pro-inflammatory cytokine TNFα can induce invasion and associated with epithelial–mesenchymal transition (EMT). However, the underlying mechanisms are not entirely clear. In this study, we showed that induces EMT human HCT116 cells thereby promotes colorectal (CRC) metastasis. TNFα-induced was characterized by acquiring mesenchymal spindle-like morphology increasing expression of N-cadherin...
Osteosarcoma is the most common primary bone cancer and notorious for pulmonary metastasis, representing a major threat to pediatric patients. An effective drug targeting osteosarcoma its lung metastasis urgently needed.In this study, sarcoma-targeting peptide-decorated disulfide-crosslinked polypeptide nanogel (STP-NG) was exploited enhanced intracellular delivery of shikonin (SHK), an extract medicinal herb, inhibit progression with minimal systemic toxicity.The targeted, loaded nanogel,...
Osteosarcoma is the most common primary malignant bone tumor in children and adolescents, with highly aggressive behavior early systemic metastasis. The survival rates for osteosarcoma remain unchanged over past two decades. Studies aiming to find new or alternative therapies patients refractory are urgently needed. Anlotinib, a novel multi‐targeted tyrosine kinase inhibitor (TKI), has exhibited encouraging clinical activity NSLCC soft tissue sarcoma, whereas its effect on not been studied....
Abstract Osteosarcoma (OS) is a primary malignant bone tumor that most commonly affects children, adolescents, and young adults. Here, we comprehensively analyze genomic, epigenomic transcriptomic data from 121 OS patients. Somatic mutations are diverse within the cohort, only TP53 significantly mutated. Through unsupervised integrative clustering of multi-omics data, classify into four subtypes with distinct molecular features clinical prognosis: (1) Immune activated (S-IA), (2) suppressed...
Abstract Signal transducer and activator of transcription 3 (STAT3) has important roles in cancer aggressiveness been confirmed as an attractive target for therapy. In this study, we used a dual-luciferase assay to identify that pectolinarigenin inhibited STAT3 activity. Further studies showed constitutive interleukin-6-induced signaling, diminished the accumulation nucleus blocked DNA-binding activity osteosarcoma cells. Mechanism investigations indicated disturbed STAT3/DNA...
Abstract The immunosuppressive tumor microenvironment (ITME) of osteosarcoma (OS) poses a significant obstacle to the efficacy existing immunotherapies. Despite attempt novel immune strategies such as checkpoint inhibitors and vaccines, their effectiveness remains suboptimal due inherent difficulty in mitigating ITME simultaneously from both system. promotion anti‐tumor immunity through induction immunogenic cell death activation cGAS‐STING pathway has emerged potential counter stimulate...
Fibroblasts become cancer-associated fibroblasts (CAFs) in the tumor microenvironment after activation by transforming growth factor-β (TGF-β) and are critically involved cancer progression. However, it is unknown whether TGF superfamily member Nodal, which expressed various tumors but not normal adult tissue, influences fibroblast to CAF conversion. Here, we report that Nodal has a positive correlation with α-smooth muscle actin (α-SMA) clinical melanoma colorectal (CRC) tissues. We show...
Osteosarcoma (OS) is the most frequent primary malignant bone tumour. Alternol, a novel compound purified from microbial fermentation products exerts anti-tumour effects across several cancer types. The effect of alternol on human OS remains to be elucidated. We first evaluated in cell lines vitro and investigated its underlying mechanism. Alternol inhibited proliferation, migration induced caspase-dependent apoptosis, G2/M cycle arrest dose time-dependent manner. Moreover, treatment signal...
Osteosarcoma (OS) is the most common primary bone malignancy in adolescents. One major obstacle for current OS treatment drug-resistance. Raddeanin A (RA), an oleanane-type triterpenoid saponin, exerts anti-tumor effects several tumor models, but effect of RA human drug-resistant remained to be elucidated. In present study, we investigated both drug-sensitive and cells its underlying mechanism. inhibited cell proliferation colony formation induced apoptotic death a dose-dependent manner...
Abstract Osteosarcoma (OS) is characterized by an unfavorable prognosis and high mortality rates, with the local recurrence attributed to residual lesions post‐surgery being a major reason for treatment failure. Precise tumor‐specific resection guidance minimize remains significant challenge. In present study, nanosystem based on aggregation‐induced emission (AIE) molecules in second near‐infrared window proposed synergistic fluorescence (FL) chemiluminescence (CL) imaging‐guided surgical...
Objectives: Cytochrome P450 3A4 (CYP3A4) is a major CYP enzyme in the liver and intestine. It involved metabolism of over 50% all drugs currently use. The present study was designed to determine genetic basis CYP3A4 variability. Methods: Single nucleotide polymorphism (SNP) analysis gene performed on 60 healthy Chinese subjects consisting 20 Han, 30 She ten Dong subjects, using direct sequencing. Linkage disequilibrium, haplotype inference Hardy–Weinberg equilibrium were also determined for...
Overexpression of the multidrug resistance (MDR)-related protein P-glycoprotein (PGP1), which actively extrudes chemotherapeutic agents from cells and significantly decreases efficacy chemotherapy, is viewed as a major obstacle in osteosarcoma chemotherapy. Anlotinib, novel tyrosine kinase inhibitor (TKI), has good anti-tumor effects variety solid tumors. However, there are few studies on mechanism anlotinib reversing chemotherapy osteosarcoma. In this study, cellular assays were performed...
Abstract Combretastatin A-4 (CA-4), a tubulin-depolymerizing agent, shows promising antitumor efficacy and has been under several clinical trials in solid tumors for 10 years. Autophagy an important pro-survival role cancer therapy, thus targeting autophagy may improve the of agents. N-myc downstream-regulated gene 1 (NDRG1) is significant stress regulatory gene, which mediates cell survival chemoresistance. Here we reported that CA-4 could induce cell-protective autophagy, combination...