A5048069511- Cancer-related molecular mechanisms research
- Mesenchymal stem cell research
- Nerve injury and regeneration
- Sarcoma Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Cancer Cells and Metastasis
- Mechanisms of cancer metastasis
- MicroRNA in disease regulation
- RNA modifications and cancer
- Wound Healing and Treatments
- Circular RNAs in diseases
- CAR-T cell therapy research
- Peptidase Inhibition and Analysis
- Fullerene Chemistry and Applications
- Endoplasmic Reticulum Stress and Disease
- Immunotherapy and Immune Responses
- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
- Cancer Immunotherapy and Biomarkers
- Graphene and Nanomaterials Applications
- Cancer Mechanisms and Therapy
- Extracellular vesicles in disease
- Phagocytosis and Immune Regulation
- Polydiacetylene-based materials and applications
- Supramolecular Self-Assembly in Materials
Shanghai First People's Hospital
2017-2025
Shanghai Jiao Tong University
2017-2025
Henan University of Technology
2022
Shanghai Cancer Institute
2019-2022
Hangzhou Dianzi University
2020
Osteosarcoma is the most common primary malignant bone tumor in children and adolescents, with highly aggressive behavior early systemic metastasis. The survival rates for osteosarcoma remain unchanged over past two decades. Studies aiming to find new or alternative therapies patients refractory are urgently needed. Anlotinib, a novel multi‐targeted tyrosine kinase inhibitor (TKI), has exhibited encouraging clinical activity NSLCC soft tissue sarcoma, whereas its effect on not been studied....
Osteosarcoma (OS) is a common malignant cancer in children and adolescents has cure rate that not improved the last two decades. CYT997 (lexibulin) novel potent microtubule-targeting agent with various anticancer activities, such as proliferation inhibition, vascular disruption, cell cycle arrest apoptosis induction, multiple cancers. However, direct cytotoxic mechanisms of have yet been fully characterized.We evaluated autophagy human osteosarcomas after treatment investigated underlying...
Abstract Osteosarcoma (OS) is a primary malignant bone tumor that most commonly affects children, adolescents, and young adults. Here, we comprehensively analyze genomic, epigenomic transcriptomic data from 121 OS patients. Somatic mutations are diverse within the cohort, only TP53 significantly mutated. Through unsupervised integrative clustering of multi-omics data, classify into four subtypes with distinct molecular features clinical prognosis: (1) Immune activated (S-IA), (2) suppressed...
Developing a drug delivery platform that possesses universal loading capacity to meet various requirements of cancer treatment is challenging yet interesting task. Herein, self-assembled gelatin/silk fibroin composite (GSC) particle based system developed via microphase separation followed by desolvation process. Thanks its preassembled stage, this GSC suitable for varying types drugs. The process fix drugs inside rapidly and densify the structure, thereby achieving efficient providing...
Abstract Fullerene C60 nanocrystals (nano‐C60) possess various attractive bioactivities, including autophagy induction and calcium/calmodulin‐dependent protein kinase IIα (CaMKIIα) activation. CaMKIIα is a multifunctional involved in many cellular processes tumor progression; however, the biological effects of activity modulated by nano‐C60 tumors have not been reported, relationship between autophagic degradation remains unclear. Herein, demonstrated to elicit reactive oxygen species...
Combinations of fibroblasts (Fbs) and corresponding epithelial cells have been widely used in many tissues, such as the skin breast to augment tissue repair remodeling.Recently, a large amount new data has indicated that nerve Fbs play critical roles Schwann (SCs) axons vitro.However, little is known regarding effects co-transplanting SCs on peripheral vivo.The aim this study was investigate effect sciatic (SN-Fbs) (SN-SCs) regeneration.We developed 5 mm nerve-defect model mice using...
Osteosarcoma (OS) is the most common primary bone malignancy in adolescents. One major obstacle for current OS treatment drug-resistance. Raddeanin A (RA), an oleanane-type triterpenoid saponin, exerts anti-tumor effects several tumor models, but effect of RA human drug-resistant remained to be elucidated. In present study, we investigated both drug-sensitive and cells its underlying mechanism. inhibited cell proliferation colony formation induced apoptotic death a dose-dependent manner...
PURPOSE Osteosarcoma (OS) is the most prevalent primary malignant bone sarcoma, characterized by its high rates of metastasis and mortality. In our previous multiomics analysis Shanghai General Hospital OS (SGH-OS) cohort, we identified four distinct subtypes, each with unique molecular characteristics clinical outcomes. Of particular importance was identification MYC-driven subtype, which exhibited poorest prognosis referred to as high-risk OS. A diagnostic tool needed for clinicians...
Abstract Given the huge cost, long research and development (R&D) time uncertain side effects of discovering new drugs, drug repositioning those approved to treat diseases clinically as drugs for other pathological conditions, especially cancers, is a potential alternative strategy. Disulfiram (DSF), an old used alcoholism, has been found exhibit anticancer activity improve chemotherapeutic efficacy in cancers by increasing number studies. In addition, combination DSF copper may be more...
Overexpression of the multidrug resistance (MDR)-related protein P-glycoprotein (PGP1), which actively extrudes chemotherapeutic agents from cells and significantly decreases efficacy chemotherapy, is viewed as a major obstacle in osteosarcoma chemotherapy. Anlotinib, novel tyrosine kinase inhibitor (TKI), has good anti-tumor effects variety solid tumors. However, there are few studies on mechanism anlotinib reversing chemotherapy osteosarcoma. In this study, cellular assays were performed...
Abstract Combretastatin A-4 (CA-4), a tubulin-depolymerizing agent, shows promising antitumor efficacy and has been under several clinical trials in solid tumors for 10 years. Autophagy an important pro-survival role cancer therapy, thus targeting autophagy may improve the of agents. N-myc downstream-regulated gene 1 (NDRG1) is significant stress regulatory gene, which mediates cell survival chemoresistance. Here we reported that CA-4 could induce cell-protective autophagy, combination...
Osteosarcoma is the most common primary malignant bone tumor. Raddeanin A ( RA ) an active oleanane‐type triterpenoid saponin extracted from traditional Chinese herb Anemone raddeana Regel that exerts antitumor activity against several cancer types. However, effect of on osteosarcoma remains unclear. In present study, we showed inhibited proliferation and induced apoptosis cells in a dose‐ time‐dependent way vitro vivo. treatment resulted excessive reactive oxygen species ROS generation JNK...
Osteosarcoma is the most common primary malignant bone tumor, and there are few ideal clinically available drugs. The bromodomain extraterminal domain (BET) protein an emerging target for aggressive cancer, but therapies targeting BET in osteosarcoma have been unsuccessful clinical trials to date, further exploration of specific inhibitors great significance. In our study, we demonstrated that NHWD-870, a potent inhibitor phase I trial, significantly inhibited tumor proliferation promoted...
Abstract Schwann cells (SCs) can promote the regeneration of injured peripheral nerves while clinical application is limited by donor site complications and inability to generate an ample amount cells. In this study, we have isolated human eyelid adipose-derived (hE-SCs) from adipose tissue identified cell phenotype function. Using immunofluorescence H & E staining, detected subtle nerve fibers SCs in tissue. Immunofluorescence staining indicated that hE-SCs expressed glial markers, such...