A5001434487- Hydrogels: synthesis, properties, applications
- Wound Healing and Treatments
- 3D Printing in Biomedical Research
- Bone Tissue Engineering Materials
- Electrospun Nanofibers in Biomedical Applications
- Nanoplatforms for cancer theranostics
- Osteoarthritis Treatment and Mechanisms
- Proteoglycans and glycosaminoglycans research
- Mesenchymal stem cell research
- Advanced Sensor and Energy Harvesting Materials
- Advanced biosensing and bioanalysis techniques
- Periodontal Regeneration and Treatments
- Cellular Mechanics and Interactions
- Polymer Surface Interaction Studies
- Graphene and Nanomaterials Applications
- Tissue Engineering and Regenerative Medicine
- Cancer-related molecular mechanisms research
- Silk-based biomaterials and applications
- Extracellular vesicles in disease
- Diabetic Foot Ulcer Assessment and Management
- RNA modifications and cancer
- Tracheal and airway disorders
- Biosensors and Analytical Detection
- RNA and protein synthesis mechanisms
- Conducting polymers and applications
Chongqing University
2021-2025
Wenzhou Medical University
2020-2025
First Affiliated Hospital of Wenzhou Medical University
2020-2025
Westlake University
2025
Hangzhou First People's Hospital
2025
Changzhou University
2023-2024
Shanghai Electric (China)
2024
Donghua University
2022-2023
McMaster University
2016-2023
Tongji Hospital
2023
Bacteria‐inspired magnetic helical micro‐/nanoswimmers can be actuated and steered in a fuel‐free manner using low‐strength rotating field, generating remotely controlled 3D locomotion with high precision variety of biofluidic environments. They are therefore envisioned for biomedical applications related to targeted diagnosis therapy. In this article, porous hollow microswimmer possessing an outer shell aggregated by mesoporous spindle‐like magnetite nanoparticles (NPs) helical‐shaped inner...
Abstract The treatment of diabetic wounds remains a major challenge in clinical practice, with chronic characterized by multiple drug‐resistant bacterial infections, angiopathy, and oxidative damage to the microenvironment. Herein, novel situ injectable HA@MnO 2 /FGF‐2/Exos hydrogel is introduced for improving wound healing. Through simple local injection, this able form protective barrier covering wound, providing rapid hemostasis long‐term antibacterial protection. MnO /ε‐PL nanosheet...
Diabetic wound (DW) therapy is currently a big challenge in medicine and strategies to enhance neurogenesis angiogenesis have appeared be promising direction. However, the current treatments failed coordinate simultaneously, leading an increased disability rate caused by DWs. Herein, whole-course-repair system introduced hydrogel concurrently achieve mutually supportive cycle of neurogenesis-angiogenesis under favorable immune-microenvironment. This can first one-step packaged syringe for...
Biopolymeric hydrogels have been widely used as carriers of therapeutic cells and drugs for biomedical applications. However, most conventional cannot be injected after gelation do not support the infiltration because static nature their network structure. Here, we develop unique cell-infiltratable injectable (Ci-I) gelatin hydrogels, which are physically cross-linked by weak highly dynamic host-guest complexations further reinforced limited chemical cross-linking enhanced stability, then...
The targeted and simultaneous delivery of diverse cargoes with vastly different properties by the same vehicle is highly appealing but challenging. Here, a bioactive nanocomposite hydrogel based on hyaluronic acid self-assembled pamidronate-magnesium nanoparticles for localized elution on-demand release ions small molecule drugs described. obtained hydrogels exhibit excellent injectability efficient stress relaxation, thereby allowing easy injection consequent adaptation to bone defects...
Abstract 3D culture of cells in designer biomaterial matrices provides a biomimetic cellular microenvironment and can yield critical insights into behaviours not available from conventional 2D cultures. Hydrogels with dynamic properties, achieved by incorporating either degradable structural components or reversible crosslinks, enable efficient cell adaptation the matrix support associated functions. Herein we demonstrate that given similar equilibrium binding constants, hydrogels containing...
The osteoblast/osteoclast and M1/M2 macrophage ratios play critical roles in delayed fracture healing. Robust osteoblast differentiation M2 polarization can substantiality promote repair; however, the combined effect of these strategies has not been previously studied. In this study, we constructed a cocktail therapy to simultaneously regulate balance. composed natural polymer hyaluronic-acid-based hydrogel (HA hydrogel, which tissue-adhesive, injectable, self-healing, anti-inflammation...
Ferroptosis, a new form of regulated cell death triggered by the iron-dependent peroxidation phospholipids, is associated with cellular metabolism, redox homeostasis, and various signaling pathways related to cancer. Aspirin widely used non-steroidal anti-inflammatory drug (NSAID) has been reported show therapeutic benefit in cancers harboring oncogenic PIK3CA, which encodes catalytic p110α subunit phosphoinositide 3-kinase (PI3K). In this study, we found that aspirin sensitized cancer cells...
The hypoxia microenvironment of solid tumors poses a technological bottleneck for ferroptosis and immunotherapy in clinical oncology. Nanoreactors based on special physiological signals tumor cells are able to avoid various tolerance mechanisms by alleviating the intracellular environment. Herein we reported nanoreactor Cu2-xSe that enabled conversion Cu elements between Cu+ Cu2+ generation O2 consumption GSH content. Furthermore, enhance catalytic ferroptosis-inducing activities...
Abstract Diabetic foot ulcer (DFU) is one of the most common complications diabetes, bringing physical and mental challenges for patients due to lack efficient curative therapy. Despite considerable advances in pharmacological surgical approaches, clinical trials DFU remain disappointing local overactive excessive inflammation. Immunomodulatory hydrogels has significant advantages overcome challenge DFUs Here, recent fabrication regenerative utilization functional altering immune...
The clinical applications of currently used photosensitizers are limited by high costs, inconvenient preparation, suboptimal biodegradability, and a lack biological activity. Humic acids (HAs) show photothermal activity can be as photosensitizer for therapy. In the presence various functional groups, HAs endowed with anti-inflammatory antioxidant activities. solubility is dependent on pH value, which soluble in neutral to alkaline conditions undergoes conformational change coiled compact...
The critical factor determining the in vivo effect of bone repair materials is microenvironment, which greatly depends on their abilities to promote vascularization and formation. However, implant are far from ideal candidates for guiding regeneration due deficient angiogenic osteogenic microenvironments. Herein, a double-network composite hydrogel combining vascular endothelial growth (VEGF)-mimetic peptide with hydroxyapatite (HA) precursor was developed build an microenvironment repair....
Although hydrogels have been widely studied because of their satisfactory biocompatibility and plasticity, application is limited in bone tissue engineering (BTE) owing to inadequate mechanical properties absence osteogenic activity. To address this issue, we developed an updated alendronate (ALN)-Ca2+/Mg2+-doped supramolecular (CMS) hydrogel based on our previously mechanically resilient "host-guest macromer" (HGM) improve the hydrogel's The CMS was prepared by introducing a new physical...
Abstract The drug‐resistant bacterial‐infected skin wound is still a severe healthcare problem. Uncontrolled bacterial infection, abundant reactive oxygen species (ROS) content, and prolonged inflammatory response are detrimental to healing. Moreover, excessive vessel growth can result in unsatisfactory scar formation. Herein, three‐step regenerative strategy based on bilayered gelatin/acryloyl β ‐cyclodextrin (BGACD) hydrogel containing physical host–guest complexations chemical crosslinks...
Abstract For various chronic wounds, bacterial infection is one of the important reasons that hinder their healing. Ion‐crosslinked antibacterial hydrogel dressings based on Ag + , Cu 2+ and Zn have made progress in clinical application. However, toxicity released metal ions cannot be ignored. Therefore, how to ensure performance dressing while reducing amount a major challenge for fabrication ion hydrogel. In this study, general method proposed design cationic ion‐crosslinked thiourea...
Abstract: Tissue engineering holds great potential for tissue repair and rejuvenation. Plant-derived exosome-like nanoparticles (ELNs) have recently emerged as a promising avenue in engineering. However, there is an urgent need to understand how plant ELNs can be therapeutically applied clinical disease management, especially regeneration. In this review, we comprehensively examine the properties, characteristics, isolation techniques of ELNs. We also discuss their impact on immune system,...
Nanocomposite hydrogels consist of a polymer matrix embedded with nanoparticles (NPs), which provide the unique bioactivities and mechanical properties. Incorporation NPs via in situ precipitation further enhances these desirable hydrogel However, noncytocompatible pH, osmolality, lengthy duration typically required for such strategies preclude cell encapsulation resultant hydrogels. Bisphosphonate (BP) exhibits variety specific excellent binding affinity to multivalent cations as magnesium...